Radiation‐induced optic neuropathy: still no treatment

Miller, Neil R.

doi:10.1111/j.1442-9071.2004.00809.x

Cited by 57 publications

(40 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pathologic specimens of optic nerves with RION show ischaemic demyelination, reactive astrocytosis, endothelial hyperplasia, obliterative endarteritis, and fibrinoid necrosis. 19 …”

Section: Pathogenesismentioning

confidence: 97%

“…However, while systemic corticosteroids have been successfully used in the management of intracranial CNS radiation effects, their use in RION has been disappointing. 19 Hyperbaric oxygen therapy has a theoretical basis for effectiveness. It is used in the treatment of radionecrosis of bone and following irradiation in poorly healing wounds in oral and maxillofacial surgery.…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Radiation-induced optic neuropathy

Danesh‐Meyer¹

2008

Journal of Clinical Neuroscience

184

108

View full text Add to dashboard Cite

“…Pathologic specimens of optic nerves with RION show ischaemic demyelination, reactive astrocytosis, endothelial hyperplasia, obliterative endarteritis, and fibrinoid necrosis. 19 …”

Section: Pathogenesismentioning

confidence: 97%

Section: Treatmentmentioning

confidence: 99%

Radiation-induced optic neuropathy

Danesh‐Meyer¹

2008

Journal of Clinical Neuroscience

184

108

View full text Add to dashboard Cite

“…44 However, the results of most studies of hyperbaric oxygen treatment in the setting of external beam related optic neuropathy have been poor. 52 A recent review on the efficacy of hyperbaric oxygen treatment found that only a few cases of radiation optic neuropathy had improved with treatment. 56 Response to treatment was better in patients who were treated shortly after the onset of visual loss (within 72 h) and in patients without optic pallor.…”

Section: Treatment Of Radiation-induced Optic Neuropathymentioning

confidence: 99%

“…50,51 The slow cellular turnover rate of endothelial and glial cells is consistent with the delayed onset of radiation-induced optic neuropathy. 52 Clinically, radiation-induced optic neuropathy typically presents with sudden, painless, monocular vision loss. Plaque brachytherapy may lead to ischaemic insult anterior to the lamina cribrosa, which causes swelling of the optic nerve head.…”

Section: Pathogenesis and Clinical Features Of Radiation-induced Optimentioning

confidence: 99%

Ocular complications following I-125 brachytherapy for choroidal melanoma

Wen

Oliver

McCannel

2009

Eye

View full text Add to dashboard Cite

Uveal melanoma has traditionally been treated with enucleation, plaque brachytherapy, or external beam radiation. Following the results of the multicenter Collaborative Ocular Melanoma Study (COMS), which established no significant difference in mortality rates between enucleation and brachytherapy, plaque brachytherapy has become the favoured modality given its potential for preservation of vision and the eye. Among the radioisotopes that have been used, iodine-125 (I-125) has become the increasingly popular choice in the United States. However, I-125 brachytherapy is associated with complications, including keratitis, iris neovascularization, neovascular glaucoma, radiation retinopathy, and optic neuropathy. The purpose of this review is to discuss the pathogenesis, clinical presentation, and management of complications related to I-125 plaque brachytherapy for choroidal melanoma.

show abstract

“…The cumulative 5-year probability of vitreous hemorrhage is 24% following treatment. Dry eye, keratitis, radiation-induced iris neovascularization, neovascular glaucoma, radiation-induced retinopathy, radiation-induced optic neuropathy, episcleral deposits, scleral necrosis and extraocular muscle alterations are the other ocular complications reported after plaque brachytherapy [43][44][45][46][47][48][49][50]. Inraoperative echographic localization of radioactive plaques can be used if required.…”

Section: Radioactive Plaque Brachytherapymentioning

confidence: 98%

Current treatment of choroidal melanoma

Tarlan

Kıratlı²

2012

Expert Review of Ophthalmology

View full text Add to dashboard Cite

Choroidal melanoma is the most common primary intraocular malignancy in adults. Alternative treatment modalities have been proposed in recent years including enucleation, local resection, plaque brachytherapy, charged-particle radiotherapy, stereotactic photon beam irradiation therapy, transpupillary thermotherapy and photodynamic therapy. This review aims to focus on all the available therapeutic options in choroidal melanoma and update the reader on the current status of each modality. Treatment of choroidal melanomas should be directed towards reducing the risk of recurrences, as it is known that recurrent tumors are associated with an increased rate of metastatic disease and poor prognosis. Advances in genetics and cytogenetics can enhance the accuracy of patient prognostication.

show abstract

Radiation‐induced optic neuropathy: still no treatment

Cited by 57 publications

References 16 publications

Radiation-induced optic neuropathy

Radiation-induced optic neuropathy

Ocular complications following I-125 brachytherapy for choroidal melanoma

Current treatment of choroidal melanoma

Contact Info

Product

Resources

About