Radiation-induced optic neuropathy 4 years after radiation: report of a case followed up with MRI

Piquemal, R.; Cottier, Jean-Philippe; Arsène, S.; Lioret, Eric; Rospars, C.; Herbreteau, Denis; Jan, M.; Renard, Jean Paul

doi:10.1007/s002340050619

Cited by 25 publications

(5 citation statements)

References 6 publications

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“…Although these 3 patients received radiation distributed throughout the whole brain, the two pituitary adenoma patients showed enhancement of the optic nerve in the intracranial segment, suggesting that this region may be relatively susceptible to radiation-induced delayed necrosis. 2 , 13 , 19 , 20 …”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of radiation-induced optic neuropathy: A single-center retrospective study

Wang

Zhou

et al. 2023

Advances in Ophthalmology Practice and Research

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of radiation-induced optic neuropathy: A single-center retrospective study

Wang

Zhou

et al. 2023

Advances in Ophthalmology Practice and Research

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“…The cause of the relatively high incidence of optic nerve injury in patients with acromegaly 12,18 , Cushing disease 10,20 or with combined chemo-and radiotherapy remain partly unclear.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Optic Neuropathy

Natale¹,

Muras²,

Cioffi³

et al. 2004

Rivista di Neuroradiologia

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Optic neuropathy resulting in permanent visual loss is an infrequent delayed complication of radiation therapy. Misdiagnosis of such a lesion may be due to the aspecifical clinical course, the usual tardive appearance and to a possible role of the initial pathology in visual pathways impairment. A radiation optic neuropathy must be suspected when visual disturbances appear in patients submitted to radiotherapy for sellar or skull base pathologies. Contrast-enhanced MR is the examination of choice because it will delineate the radiation-induced lesion and rule out compression of the optic nerves or optic chiasm by the tumoral pathology. The radionecrotic lesion at MR is characterized by segmental swelling with gadolinium enhancement of the visual pathways. Two patients with rapid visual loss about one year after radiotherapy are described. Corticoids and hyperbaric oxygen therapy may be useful in the treatment. The severity of this complication focuses on a strict use of radiotherapy for benign lesions of the sellar and parasellar region.

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“…31,36,57,58 In two cases reported by Archer et al, 13 patients received radiation distributed across the entire brain, and both displayed prechiasmatic optic nerve enhancement, suggesting that this anatomical area may be relatively vulnerable to delayed radionecrosis, but there are no previous reports of whole brain radiation leading to RION. 7,11,13,38,[58][59][60][61][62][63] The occurrence of the disease significantly affects the patients' quality of life, whose visual acuity is less than 20/200 (about 85% of the cases), with most of the cases progressing to no light perception (45% of cases). 7,24,52,64 Speckter et al 12 reported that RION occurred in a period of 10 to 20 months (mean of 18 months) after treatment, while Danesh-Meyer 7 reported that visual loss occurred within 3 months to 9 years after exposure to RT.…”

Section: Pathophysiology Of Rionmentioning

confidence: 99%

Radiation-Induced Optic Neuropathy: Literature Review

Ataídes

Silva

Baldin

2020

Neuro-Ophthalmology

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Radiation-induced optic neuropathy (RION) is a rare disease caused by exposure of the optic nerves to radiation during radiotherapy procedures for head and neck tumours. The purpose of this study was to review and summarise the epidemiology, risk factors, clinical presentations, pathphysiology characteristics, diagnosis, and management of RION. Its occurrence is associated with cumulative doses of radiation above 50 Gy, presence of multi-morbidities and the presence of concomitant chemotherapy and radiotherapy. It manifests with acute, painless, and monocular loss of vision, and these symptoms appear late after the radiation exposure. The diagnosis of the disease occurs by exclusion and, mainly, by the clinical analysis of the case associated with the time of radiation exposure. Treatment does not seem promising and there is not an effective cure. In this review, we mainly focus on compiling existing information on the topic and providing knowledge for early diagnosis and more efficient treatment.

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Radiation-induced optic neuropathy 4 years after radiation: report of a case followed up with MRI

Cited by 25 publications

References 6 publications

Clinical characteristics of radiation-induced optic neuropathy: A single-center retrospective study

Clinical characteristics of radiation-induced optic neuropathy: A single-center retrospective study

Radiation-Induced Optic Neuropathy

Radiation-Induced Optic Neuropathy: Literature Review

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