Radiation-induced myelopathy in long-term surviving metastatic spinal cord compression patients after hypofractionated radiotherapy: a clinical and magnetic resonance imaging analysis

Maranzano, Ernesto; Bellavita, Rita; Floridi, Piero; Celani, Grazia; Righetti, Enrico; Lupattelli, Marco; Panizza, Bianca Moira; Frattegiani, Alessandro; Pelliccioli, G.P.; Latini, P

doi:10.1016/s0167-8140(01)00356-5

Cited by 51 publications

(29 citation statements)

References 34 publications

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“…Medulla spinalis gibi yavaş prolifere olan dokularda geç etkiler çoğun-lukla kalıcı hasarlara neden olur. [2,3,[6][7][8] Yasui ve ark. RM'sini klinik spektruma göre dört kategoriye ayırmışlardır: a) Akut parapleji veya kuadripleji, b) Alt motor nöron bulguları, c) Akut geçici RM, d) Kronik progresif RM.…”

Section: Discussionunclassified

“…Günlük doz olarak 180-200 cGy'in üzerinde ışın alanlarda veya total spinal doz olarak 4600-5000 cGy'den fazla alanlarda gö-rülme sıklığı daha yüksektir. [2,5,6,9,10] Radyoterapi sonrası oluşan medulla spinalis hasarlarının en sık görüleni geçici miyelopatidir. RT ardından ortalama dört-altı ay sonra görülür.…”

Section: Discussionunclassified

“…Kronik miyelopati çok ciddi ve geç bir komplikasyon olup, bundan dolayı spinal kord radyoterapide doz sınırlayıcı organdır. [4][5][6][7][8][9] Bu yazıda, nazofarenks kanserli hastada kemoradyoterapi sonrası gelişen radyasyon miyelopatisinin klinik özellikleri ve tedavisi tartışıldı. rildi.…”

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Radiation myelopathy: a case report

Cihan

2013

TJ Oncol

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Normal tissue injury may lead to severe late side effects after therapeutic use of irradiation. Radiation myelopathy (RM) is an uncommon complication of therapeutic irradiation whenever the spinal cord is included within the radiation treatment field. Several factors such as radiation dose, fractination, linear energy transfer, chemotherapy, modify its occurrence and severity. Herein, we report a 43-year-old male patient with nasopharyngeal cancer who developed RM after concomitant chemoradiotherapy and discussed the literature.

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Section: Discussionunclassified

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Radiation myelopathy: a case report

Cihan

2013

TJ Oncol

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“…In addition, absence of spinal cord metastases or primary spinal cord lesions is required for the diagnosis (Kadir et al 2012 ;Maranzano et al 2001 ;Yasui et al 1992 ). Several therapies such as corticosteroids, anticoagulation, and hyperbaric oxygen have been tried with limited benefi ts.…”

Section: Radiation-induced Myelopathymentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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“…Conversely, large single fractions of radiation have been used for palliation of bone metastases without ESCC [42]. Recently, Maranzano et al have reported that the delivery of two fractions of 800 cGy 1 week apart in ESCC patients with poor neurologic prognosis is safe and apparently as efficicaous as more conventional schedules; this finding requires further evaluation and confirmation [43,44]. Most radiation oncologists adhere to more standard schedules of 2500-3600 cGy in 10-15 fractions.…”

Section: Specific Antineoplastic Therapies Radiation Therapymentioning

confidence: 99%

Spinal Cord Compression

Ribas

Schiff

2012

Curr Treat Options Neurol

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Spinal cord disease represents a major cause of morbidity and suffering in cancer patients. Prevention or minimization of neurologic deficits depends on an understanding of early symptoms, clinical course, and treatment options. Early diagnosis is crucial, as current treatments usually arrest the course of the disease but much less commonly restore lost neurologic function. This article will review the epidemiology, pathophysiology, symptomatology, diagnosis, and management of the causes of spinal cord dysfunction directly related to cancer. It will briefly discuss myelopathies related to paraneoplasia and treatment complications. Epidural spinal cord compressionSpinal cord or cauda equina dysfunction resulting from tumor growth in the spinal epidural space is commonly referred to as epidural spinal cord compression (ESCC). In some ways, spinal epidural metastasis (SEM) may be a better term, as it encompasses the phenomena of root, cauda equina, and minor degrees of thecal sac compression SEM/ESCC is the most common cause of spinal cord dysfunction in cancer patients, and will receive the bulk of attention in this article. EpidemiologyAlthough careful, contemporary population-based studies are unavailable, the best evidence suggests that 5% of patients dying of cancer have suffered ESCC [1]. With more than 500,000 Americans succumbing to cancer yearly, there are likely to be more than 25,000 cases of ESCC yearly in the United States.Neurol Clin N Am

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Radiation-induced myelopathy in long-term surviving metastatic spinal cord compression patients after hypofractionated radiotherapy: a clinical and magnetic resonance imaging analysis

Cited by 51 publications

References 34 publications

Radiation myelopathy: a case report

Radiation myelopathy: a case report

Female Pelvis: Genital Organs

Spinal Cord Compression

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