Radiation-induced meningiomas after high-dose cranial irradiation

Godlewski, Bartosz; Drummond, Katharine J.; Kaye, Andrew H.

doi:10.1016/j.jocn.2012.05.011

Cited by 42 publications

(37 citation statements)

References 42 publications

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“…Radiation-induced meningiomas are more aggressive than sporadic tumors, with higher recurrence rates after treatment and more frequent findings of atypical or anaplastic histology [2,3], as in our patient.…”

Section: Discussionsupporting

confidence: 60%

Radiation-induced malignant meningioma following proton beam therapy for a choroidal melanoma

Scaringi

Minniti

Bozzao

et al. 2015

Journal of Clinical Neuroscience

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Section: Discussionsupporting

confidence: 60%

Radiation-induced malignant meningioma following proton beam therapy for a choroidal melanoma

Scaringi

Minniti

Bozzao

et al. 2015

Journal of Clinical Neuroscience

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“…44,94,95 Meningiomas are the most frequently reported RIC following exposure to intermediate-or high-dose RT. 58,59 In a recent meta-analysis of 66 studies of RT for a wide range of conditions (mostly tumours), only 143 patients were found to have developed meningiomas attributable to the RT (median age when receiving RT was 12 years). It was notable that this group presented with meningioma at a younger age (80% at less than 22 years) compared with spontaneous tumours which peak in adults aged 50-70 years.…”

Section: Brain Cancermentioning

confidence: 99%

Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation

McKeown

Hatfield

Prestwich

et al. 2015

BJR

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Most radiotherapy (RT) involves the use of high doses (.50 Gy) to treat malignant disease. However, low to intermediate doses (approximately 3-50 Gy) can provide effective control of a number of benign conditions, ranging from inflammatory/proliferative disorders (e.g. Dupuytren's disease, heterotopic ossification, keloid scarring, pigmented villonodular synovitis) to benign tumours (e.g. glomus tumours or juvenile nasopharyngeal angiofibromas). Current use in UK RT departments is very variable. This review identifies those benign diseases for which RT provides good control of symptoms with, for the most part, minimal side effects. However, exposure to radiation has the potential to cause a radiation-induced cancer (RIC) many years after treatment. The evidence for the magnitude of this risk comes from many disparate sources and is constrained by the small number of long-term studies in relevant clinical cohorts. This review considers the types of evidence available, i.e. theoretical models, phantom studies, epidemiological studies, longterm follow-up of cancer patients and those treated for benign disease, although many of the latter data pertain to treatments that are no longer used. Informative studies are summarized and considered in relation to the potential for development of a RIC in a range of key tissues (skin, brain etc.). Overall, the evidence suggests that the risks of cancer following RT for benign disease for currently advised protocols are small, especially in older patients. However, the balance of risk vs benefit needs to be considered in younger adults and especially if RT is being considered in adolescents or children.

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“…The recurrence rate of RIMs managed solely through surgical resection has ranged from 0 to 43%, depending on the length of follow-up and whether radiotherapy (RT) was used concurrently (Table 2) [5, 30–33]. De Tommasi and associates reported six operated cases of RIMs [31].…”

Section: Current Therapeutic Modalities For Rimsmentioning

confidence: 99%

The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

Mansouri

Badhiwala

Mansouri

et al. 2014

BioMed Research International

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Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. Therefore, other therapeutic modalities, such as stereotactic radiosurgery, have emerged. In the current review, we provide an overview of the historical outcomes achieved for RIMs through radiosurgery and microsurgical resection. Furthermore, we provide a discussion of clinical and radiological parameters that affect the decision-making process with regard to the management of RIMs. We also provide an outline of recent changes in our understanding of RIMs, based on molecular and genetic markers, and how these will change our management perspective. We conclude the review by summarizing some of the current obstacles in the management of RIMs with SRS and how current and future research can address these challenges.

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Radiation-induced meningiomas after high-dose cranial irradiation

Cited by 42 publications

References 42 publications

Radiation-induced malignant meningioma following proton beam therapy for a choroidal melanoma

Radiation-induced malignant meningioma following proton beam therapy for a choroidal melanoma

Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation

The Evolving Role of Radiosurgery in the Management of Radiation-Induced Meningiomas: A Review of Current Advances and Future Directions

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