Radiation-Induced Lung Injury (RILI)

Giuranno, Lorena; Ient, Jonathan; Ruysscher, Dirk De; Vooijs, Marc

doi:10.3389/fonc.2019.00877

Cited by 241 publications

(235 citation statements)

References 206 publications

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“…DEX also attenuated fibrosis bỹ 70% in the underlying lungs that were exposed to radiation during administration of RT to the breast. This result is compatible with other studies where DEX attenuates RT-induced inflammation and lung fibrosis [143], but the present work is the first to link this to the actions of ATX and LPA signaling on breast fibrosis.…”

Section: Lpa Signaling and Radiation Fibrosis Syndromesupporting

confidence: 93%

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Benesch

Tang

Brindley

2020

Cancers

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After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor, GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the intervening time, a deeper understanding of the role of the autotaxin–lysophosphatidate (LPA)–lipid phosphate phosphatase axis in breast cancer progression and treatment resistance has emerged. Concordantly, appreciation of the tumor microenvironment and chronic inflammation in cancer biology has matured. The role of LPA as a central mediator behind these concepts has been exemplified within the breast cancer field. In this review, we will summarize current challenges in breast cancer therapy and delineate how blocking LPA signaling could provide novel adjuvant therapeutic options for overcoming therapy resistance and adverse side effects, including radiation-induced fibrosis. The advent of autotaxin inhibitors in clinical practice could herald their applications as adjuvant therapies to improve the therapeutic indexes of existing treatments for breast and other cancers.

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Section: Lpa Signaling and Radiation Fibrosis Syndromesupporting

confidence: 93%

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Benesch

Tang

Brindley

2020

Cancers

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“…In addition to the heart, the lungs are also at risk of developing short-and long-term injuries after exposure to ionizing radiation [98][99][100]. In the pathogenesis of radiation-induced lung injury, several Cancers 2020, 12, 415 6 of 22 phases are recognized [100].…”

Section: Cardiopulmonary Tissue Toxicity From Rtmentioning

confidence: 99%

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Schlaak

SenthilKumar

Boerma

et al. 2020

Cancers

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Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short-and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.

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“…9 On the contrary, high doses increase the amount of fibrosis in the nerve tissue. 10 Radiation application for the treatment of breast cancer was first performed in 1949. However, because of the decrease in survival due to the cardiac side effects at mortal level, hesitations occurred in the application of RT.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Brachial Plexopathy in Breast Cancer and the Role of Surgical Treatment

Kıbıcı

Erok²,

Atça

2020

Indian Journal of Neurosurgery

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Objective We aimed to evaluate improvement in the pain, motor, and sensory functions after neurosurgical intervention, by objective methods in patients with radiation-induced brachial plexopathy (RIBP), as a complication of radiotherapy (RT). Materials and Methods In our study, 11 patients, who experienced grade 3 or 4 brachial plexopathy according to the LENT-SOMA (late effects of normal tissue—subjective, objective, management, analytic) side-effect index, as a complication of RT which was performed after being operated for breast cancer, were included. In the postoperative period pain, sensation, and motor function loss were followed. Results There was apparent regression in the pain. The mean visual analogue scale (VAS) value decreased to 4 from the preoperative VAS value of 9.4. However, no significant improvement was observed in either sensory and motor functions. Conclusion RIBP is a progressive disease in breast cancer patients after radiotherapy. Evaluation of the results of applied surgical treatments and changes in the results with time is important to direct the treatment. Neurolysis should only be considered when other treatment methods fail and should be considered as an irreversible and potentially permanent procedure.

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Radiation-Induced Lung Injury (RILI)

Cited by 241 publications

References 206 publications

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Radiation-Induced Brachial Plexopathy in Breast Cancer and the Role of Surgical Treatment

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