Radiation-induced intracranial neoplasms. A report of three possible cases

Anderson, Janice R.; Treip, C. S.

doi:10.1002/1097-0142(19840201)53:3<426::aid-cncr2820530310>3.0.co;2-l

Cited by 87 publications

(17 citation statements)

References 7 publications

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“…Such a development, which has been reported to occur from 3 to 9 years after apparently successful cure of the leukemia, has been confirmed by us in 4 unpublished cases referred to us for consultation, all in patients in their second decade. It is of significance that in three of these patients the malignant gliomas were multifocal, as was the case in two of the patients reported by others (135,140). This development of iatrogenic gliomas needs further investigation to assess its frequency, identify more closely the risk factors involved in the prophylactic treatment of the CNS in acute lymphocytic leukemia, and determine what modifications should be brought to the modalities of therapy.…”

Section: Radiation-induced Gliomasmentioning

confidence: 80%

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The correlation of neoplastic vulnerability with central neuroepithelial cytogeny and glioma differentiation

Rubinstein

1987

J Neuro-Oncol

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The vulnerability of neuroepithelial cells in the central nervous system (CNS) to neoplastic transformation results from the interaction of several factors: the existence of a reserve population of stem cells, the capability of differentiated cells to reenter the kinetic cycle, the number of replicating cells at risk at a particular time, the length of time during which a particular cell population remains in the cycle, the state of differentiation and the further differentiation potential of that population, and the steps of differentiation that are achieved in successive cell generations. This concept explains many aspects of CNS tumor incidence and the relationship of central neuroepithelial embryonal tumors to tumors of adult cell type. The incidence of different types of central neuroepithelial tumors can be correlated with the width of the window of neoplastic vulnerability. Examples illustrating the existence of only a narrow window include such rare tumors as medulloepitheliomas, cerebral neuroblastomas, gangliogliomas and ependymoblastomas. By contrast, cerebellar medulloblastomas, astrocytomas, mixed astrocytomas and oligodendrogliomas, and glioblastomas exemplify instances in which a relatively wider window of vulnerability exists in the light of cellular neuro-ontogeny and of the capacity of glial cells for postnatal replication. The relationship that may occasionally be established between the development of a glioma and the production of cellular gliosis such as may follow brain injury or accompany multiple sclerosis can also be viewed in the light of that concept. Increasing awareness is needed concerning the development of postradiation gliomas, in particular after the apparently successful treatment of acute lymphocytic leukemia.

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Section: Radiation-induced Gliomasmentioning

confidence: 80%

“…About 40 cases of human glioma have been published following radiation of the CNS for therapeutic or, occasionally, diagnostic purposes (135)(136)(137)(138)(139)(140)(141). These occurrences are being rapidly reported at an increasing rate.…”

Section: Radiation-induced Gliomasmentioning

confidence: 99%

The correlation of neoplastic vulnerability with central neuroepithelial cytogeny and glioma differentiation

Rubinstein

1987

J Neuro-Oncol

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“…The number of case reports documenting radiation-induced malignant gliomas in humans had risen sharply since 1970. It was estimated that the risk of developing a radiationinduced tumour after radiation therapy to the brain is approximately 1 Á/3% [5,16]. However, data is lacking in the literature concerning radiation-induced spinal tumour, not to mention spinal GBM.…”

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confidence: 99%

Radiation-induced spinal glioblastoma multiforme

et al. 2006

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“…Many multiple meningiomas have been explained as possible radiation-induced neoplasms. [15][16][17][18][19][20][21] Cases of multiple meningiomas also occur with stigmata of von Recklinghausen's disease. 4,[22][23][24][25][26][27] The reported incidence of multiple meningiomas has ranged between 1% and 2% of all meningioma cases; but since the introduction of CT, the incidence has averaged 7%.…”

Section: Discussionmentioning

confidence: 99%