Radiation-induced cranial nerve palsy

Berger, Paul; Bataini, J. P.

doi:10.1002/1097-0142(197707)40:1<152::aid-cncr2820400125>3.0.co;2-e

Cited by 123 publications

(38 citation statements)

References 14 publications

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“…Research regarding radiation‐associated lower cranial neuropathies in oropharyngeal cancer is limited. Our review of 23 publications reporting radiation‐associated lower cranial neuropathies in head and neck cancer survivors found only 3 authors reporting their experience with this late‐toxicity of oropharyngeal cancer therapy . Furthermore, the contribution of radiation‐associated lower cranial neuropathies to late‐RAD is rarely described.…”

Section: Discussionmentioning

confidence: 99%

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Hutcheson¹,

Yuk

Holsinger

et al. 2015

Head & Neck

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Section: Discussionmentioning

confidence: 99%

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Hutcheson¹,

Yuk

Holsinger

et al. 2015

Head & Neck

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“…Radiation-related CNP is difficult to diagnose because unified criteria are lacking and because it is also difficult to distinguish from recurrence-induced CNP [5,12,15]. However, new MRI techniques such as diffusion-weighted imaging are widely used to confirm the correct diagnosis [16,17,18].…”

Section: Schlüsselwörtermentioning

confidence: 99%

Radiation-induced cranial neuropathy in patients with nasopharyngeal carcinoma

et al. 2012

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“…6 Apart from that study, fewer than 40 patients with NPC who developed conventional radiation therapy-induced cranial nerve palsy have been reported in the English literature since 1966 (see Table 1). [5][6][7][8][9][10][11][12][13][14][15] Cranial neuropathy is of particular practical interest in terms of making a differential diagnosis, because it is also a common presenting manifestation in patients with NPC. Victims of cranial neuropathy suffer from various distressing disabilities; however, treatment for these patients has not been addressed in previous reports.…”

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confidence: 99%

Radiation‐related cranial nerve palsy in patients with nasopharyngeal carcinoma

Lin

Jen

Lin

2002

Cancer

143

104

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BACKGROUNDCranial nerve palsy is a rare complication after patients with nasopharyngeal carcinoma (NPC) receive radiotherapy using a technique that delivers 180–200 centigrays (cGy) per day. Cranial neuropathy is of particular clinical interest in terms of making a differential diagnosis, because it is also a common presenting manifestation in patients with NPC. Cranial neuropathy may lead to distressing signs and symptoms in these patients, and their treatment has not been addressed in previous reports. This article presents the authors' experience with radiotherapy‐related cranial nerve palsy in patients with NPC.METHODSNineteen patients were diagnosed with radiation‐related neuropathy. Patients with recurrent tumors or with a suspicion of persistent or recurrent tumors were excluded. Most patients were treated using 180 cGy or 200 cGy per fraction per day. The total dose was 7000–13,000 cGy to the nasopharynx and 5000–9000 cGy to the neck. Unilateral vocal cord paralysis alone and hearing loss were not included in the analysis.RESULTSThere were 15 male patients and 4 female patients. The latency before palsy occurred was 12–240 months. Single nerve palsy developed in four patients, including two patients with hypoglossal palsy and two patients with recurrent laryngeal palsy. Two patients had three nerve palsies each. The other 13 patients presented with 2 nerve palsies each. Vagus and hypoglossal palsy appeared to be a frequent combination and occurred in 11 patients. Overall, there were 17 patients with hypoglossal palsy (7 bilateral, 8 left‐sided, and 2 right‐sided), 11 patients with vagus palsy (2 bilateral, 7 left‐sided, and 2 right‐sided), 6 patients with recurrent laryngeal nerve palsy (5 bilateral), and 2 patients with accessory palsies (all bilateral). Marked neck fibrosis was present in 12 patients. Patients who had vocal cord paralysis suffered from easy choking and hoarseness. Severe respiratory difficulty occurred in two patients who had bilateral vocal cord palsy. Surgical procedures included laryngoplasty, tracheostomy, and gastrostomy. Quality of life improved considerably after patients underwent surgery.CONCLUSIONSRadiotherapy‐related cranial nerve palsy may occur in patients with NPC after they receive conventional radiotherapy. Hypoglossal nerve palsy was found the most frequently in this series, followed by vagus nerve palsy and recurrent laryngeal nerve palsy. Neck fibrosis and the course of the three nerves through the neck may be important risk factors for the development of palsy. The diagnosis must be made only after the possibilities of tumor‐induced palsy and idiopathic palsy are excluded. Surgery is helpful in improving the quality of life in many patients. Cancer 2002;95:404–9. © 2002 American Cancer Society.DOI 10.1002/cncr.10668

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Radiation-induced cranial nerve palsy

Cited by 123 publications

References 14 publications

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Late radiation‐associated dysphagia with lower cranial neuropathy in long‐term oropharyngeal cancer survivors: Video case reports

Radiation-induced cranial neuropathy in patients with nasopharyngeal carcinoma

Radiation‐related cranial nerve palsy in patients with nasopharyngeal carcinoma

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