Radiation-induced circulating miRNA expression in blood of head and neck cancer patients

Pasi, Francesca; Corbella, Franco; Baio, Ambrogia; Capelli, Enrica; Silvestri, Annalisa De; Tinelli, Carmine; Nano, Rosanna

doi:10.1007/s00411-020-00832-3

Cited by 9 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent studies, tsRNAs have been suggested to play a regulatory role by RNAi or binding with ribosome and translation factors [17,18]. They are involved in transcription, translation, ribosome biogenesis, cell proliferation, apoptosis, modulation of the DNA damage response, vesicle-mediated intercellular communication, tumor suppression, and neurological disorders [15,21,[41][42][43]. Our results showed that ionizing radiation can affect the level of circulating tsRNAs in the long term.…”

Section: Discussionmentioning

confidence: 51%

Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure

Wei

Bai

Chen

et al. 2021

IJMS

View full text Add to dashboard Cite

The effective and minimally invasive radiation biomarkers are valuable for exposure scenarios in nuclear accidents or space missions. Recent studies have opened the new sight of circulating small non-coding RNA (sncRNA) as radiation biomarkers. The tRNA-derived small RNA (tsRNA) is a new class of sncRNA. It is more abundant than other kinds of sncRNAs in extracellular vesicles or blood, presenting great potential as promising biomarkers. However, the circulating tsRNAs in response to ionizing radiation have not been reported. In this research, Kunming mice were total-body exposed to 0.05–2 Gy of carbon ions, protons, or X-rays, and the RNA sequencing was performed to profile the expression of sncRNAs in serum. After conditional screening and validation, we firstly identified 5 tsRNAs including 4 tRNA-related fragments (tRFs) and 1 tRNA half (tiRNA) which showed a significant level decrease after exposure to three kinds of radiations. Moreover, the radiation responses of these 5 serum tsRNAs were reproduced in other mouse strains, and the sequences of them could be detected in serum of humans. Furthermore, we developed multi-factor models based on tsRNA biomarkers to indicate the degree of radiation exposure with high sensitivity and specificity. These findings suggest that the circulating tsRNAs can serve as new minimally invasive biomarkers and can make a triage or dose assessment from blood sample collection within 4 h in exposure scenarios.

show abstract

Section: Discussionmentioning

confidence: 51%

Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure

Wei

Bai

Chen

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Selected miRNA levels in the serum of patients who underwent radiotherapy for head and neck cancer were found to be correlated with disease remission (21,22). Promising results have also been reported for other types of cancer, including breast or head and neck cancer (23,24).…”

Section: Dose-dependent Expression Of Extracellular Micrornas In Hct116 Colorectal Cancer Cells Exposed To High-dose-rate Ionising Radiatmentioning

confidence: 86%

Dose‑dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high‑dose‑rate ionising radiation

et al. 2021

View full text Add to dashboard Cite

“…Regulatory ncRNAs have been widely studied in recent years and play key roles in HNSCC proliferation and metastasis (Wang et al, 2018;Wang et al, 2020) (Table 1). Related studies have demonstrated that several ncRNAs are abnormal in radiosensitive or radioresistant HNSCC tissues (Qu et al, 2015a;Qu et al, 2015b;de Jong et al, 2015;Suh et al, 2015;Xu et al, 2015;Gao et al, 2017;Hess et al, 2017;Vahabi et al, 2019;Pasi et al, 2020). The differential expression of certain ncRNAs can significantly affect the response of HNSCC cells to chemotherapy or radiotherapy, suggesting that ncRNAs can regulate the sensitivity of cancer cells to treatment.…”

Section: Ncrnasmentioning

confidence: 99%

Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment

Yang,

2024

Front. Pharmacol.

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant tumor worldwide, with high morbidity and mortality. Surgery and postoperative chemoradiotherapy have largely reduced the recurrence and fatality rates for most HNSCCs. Nonetheless, these therapeutic approaches result in poor prognoses owing to severe adverse reactions and the development of drug resistance. Ferroptosis is a kind of programmed cell death which is non-apoptotic. Ferroptosis of tumor cells can inhibit tumor development. Ferroptosis involves various biomolecules and signaling pathways, whose expressions can be adjusted to modulate the sensitivity of cells to ferroptosis. As a tool in the fight against cancer, the activation of ferroptosis is a treatment that has received much attention in recent years. Therefore, understanding the molecular mechanism of ferroptosis in HNSCC is an essential strategy with therapeutic potential. The most important thing to treat HNSCC is to choose the appropriate treatment method. In this review, we discuss the molecular and defense mechanisms of ferroptosis, analyze the role and mechanism of ferroptosis in the inhibition and immunity against HNSCC, and explore the therapeutic strategy for inducing ferroptosis in HNSCC including drug therapy, radiation therapy, immunotherapy, nanotherapy and comprehensive treatment. We find ferroptosis provides a new target for HNSCC treatment.

show abstract

Radiation-induced circulating miRNA expression in blood of head and neck cancer patients

Cited by 9 publications

References 26 publications

Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure

Circulating tRNA-Derived Small RNAs as Novel Radiation Biomarkers of Heavy Ion, Proton and X-ray Exposure

Dose‑dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high‑dose‑rate ionising radiation

Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment

Contact Info

Product

Resources

About