Radiation-induced chromosome damage in human peripheral blood lymphocytes in vitro II. RBE and dose-rate studies with 60Co γ- and X-rays

Scott, David; Sharpe, Heather B. A.; Batchelor, A.L.; Evans, H. J.; Papworth, D.G.

doi:10.1016/0027-5107(70)90061-8

Cited by 44 publications

(8 citation statements)

References 19 publications

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“…Differences from other work may arise from assuming an exposure exponent equal to 2 when It may be rather less than that [32,119], by as suming negligibility of all formula terms other than that given here [9,32], or through use of different times of irradiation and sampling [32,52]. In any event the proportionality constants are within the range of those found by others using human leukocytes, and they are consistent among the subjects used here.…”

Section: Discussionsupporting

confidence: 63%

Cytogenetics and Fanconi's Anemia: experimental and other studies of a family

Loughman¹

1973

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Section: Discussionsupporting

confidence: 63%

Cytogenetics and Fanconi's Anemia: experimental and other studies of a family

Loughman¹

1973

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“…However, previous studies comparing the dose rate effect of cobalt-60 gamma irradiation of human lymphocytes failed to demonstrate an appreciable difference in the level of radiation effect as measured by chromosomal aberrations when human lymphocytes were exposed to the equivalent dose of radiation (approximately 2 or 4 Gy) and delivered over a 2-or 10-minute time period. 18 To our knowledge, our study is the first study to demonstrate an actual effect of dose rate on pain control rates in the treatment of TN and potentially warrant further exploration. However, this study raises intriguing considerations for treatment of patients with TN.…”

Section: Discussionmentioning

confidence: 80%

Higher dose rate Gamma Knife radiosurgery may provide earlier and longer-lasting pain relief for patients with trigeminal neuralgia

Lee¹,

Sandhu²,

Miller³

et al. 2015

JNS

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Prior studies investigating the role of dose rate in Gamma Knife radiosurgical ablation for TN have not used validated outcome tools to measure pain preoperatively. Consequently, differences in pain outcomes have been difficult to measure. By administering pain scales both preoperatively as well as postoperatively, the authors have identified statistically significant differences in pain intensity and pain interference with activities of daily living when comparing higher versus lower dose rates. Radiosurgery with a higher dose rate results in more pain relief at the early follow-up evaluation, and it may result in a lower recurrence rate at later follow-up.

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“…While the probability of induction of two DSB in sufficient proximity through a radiomimetic chemical decreases rapidly for lower doses, any dose of ionizing radiation, even a single track, can in principle induce a dic. The probability of single track dic increases Ž with increasing LET in a systematic fashion Scott et al, 1969Scott et al, , 1970Lloyd et al, 1975;Virsik et al, 1977;Dol-. phin, 1978 . Moreover, radiomimetic chemicals are well-known human clastogens and strictly regulated, rendering significant and inadvertent exposure of the general population to these chemicals highly unlikely.…”

Section: Specificitymentioning

confidence: 99%

“…of three ICRU, 1986 . Hence, X-rays are generally more efficient in inducing dic than are Co-60 gamma rays ŽNeary et al, 1967;Scott et al, 1970;Lloyd et al, 1975;. Virsik et al, 1977;Schmid et al, 1984 .…”

Section: Linear Dose Coefficient Amentioning

confidence: 99%

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How radiation-specific is the dicentric assay?

Hoffmann

Schmitz-Feuerhake

1999

J Expo Sci Environ Epidemiol

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Question: Quantitative cytogenetic analysis of structural chromosome aberrations in human peripheral blood lymphocytes is widely used as an assay to Ž . detect and quantify exposure to a variety of clastogens. Unstable chromosome rearrangements, dicentric chromosomes dic and centric ring chromosomes Ž . Ž . centric r , are routinely used as biomarkers to assess human exposure to ionizing radiation "biological dosimetry" . In the moderate-to high-dose range many authors consider the dic assay sufficiently radiation-specific for both practical and legal purposes. However, specificity has never been evaluated in quantitative terms. The high sensitivity of the assay would in principle allow for applications in the range of low-dose exposure which has been a major concern in epidemiologic studies. Validity of the assay then critically depends on specificity. Methods: A mathematical model is proposed which includes as parameters the decline of dicentric aberrations in ÕiÕo, the linear dose coefficient for the induction of dic and the average total radiation exposure of the population. To assess radiation-specificity of the dic assay the equilibrium dicentric rate due to radiation is compared to measurements of the background rate of dic in unexposed controls. Results: Environmental and medical radiation combined account for at least about 80% of the average background level of dicentrics. Conclusion: It is concluded that the dicentric assay is highly specific for ionizing radiation and can therefore be used to assess prior exposure in the dose range of interest in environmental epidemiology.

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Radiation-induced chromosome damage in human peripheral blood lymphocytes in vitro II. RBE and dose-rate studies with 60Co γ- and X-rays

Cited by 44 publications

References 19 publications

Cytogenetics and Fanconi's Anemia: experimental and other studies of a family

Cytogenetics and Fanconi's Anemia: experimental and other studies of a family

Higher dose rate Gamma Knife radiosurgery may provide earlier and longer-lasting pain relief for patients with trigeminal neuralgia

How radiation-specific is the dicentric assay?

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