Radiation-induced chromosome damage in human peripheral blood lymphocytes in vitro I. RBE and dose-rate studies with fast neutrons

Scott, David; Sharpe, Heather B. A.; Batchelor, A.L.; Evans, H. J.; Papworth, D.G.

doi:10.1016/0027-5107(69)90015-3

Cited by 35 publications

(8 citation statements)

References 22 publications

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“…7 MeV exposure and two experiments of Biola, Le Go, Vacca, Ducatez, Dacher and Bourguignon (1974) using the Crac and Nereide reactors, and the work of Carrano (1975) with the Janus reactor . The closest agreement, however, is with the value of Scott, Sharpe, Batchelor, Evans and Papworth (1969), which was also obtained on the BEPO reactor using the same converter plate and therefore an identical spectrum .…”

Section: Resultsmentioning

confidence: 61%

Chromosome Aberrations Induced in Human Lymphocytes by Neutron Irradiation

Lloyd¹,

Purrott²,

Dolphin³

et al. 1976

International Journal of Radiation Biology and Related Studies

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In vitro dose--response curves of unstable chromosome aberrations in human lymphocytes have been obtained for neutron spectra of mean energies 0-7, 0-9, 7-6 and 14-7 MeV. The aberration yields have been fitted to the quadratic function Y = alphaD + betaD2, which is consistent with the single-track and two-track model of aberration formation. However with high-LET radiation, the linear component of yield, corresponding to damage caused by single tracks, predominants, and this term becomes more dominant with increasing LET, so that for fission spectrum neutrons the relationship is linear, Y = alphaD. At low doses, such as those recieved by radiation workers, limiting r.b.e. values between 13 and 47 are obtained relative to 60Co gamma-radiation. At higher doses, as used in radiotherapy, the values are much lower; ranging from 2-7 to 8 at 200 rad of equivalent gamma-radiation. Both sets of r.b.e. values correlate well with track-averaged LET but not with dose-averaged LET. When the numbers of cells without aberrations are plotted against radiation dose, curves are obtained which are similar in shape to those for conventional cell-survival experiments with comparable neutron spectra. The Do values obtained in the present study are close to those from other cell system.

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Section: Resultsmentioning

confidence: 61%

Chromosome Aberrations Induced in Human Lymphocytes by Neutron Irradiation

Lloyd¹,

Purrott²,

Dolphin³

et al. 1976

International Journal of Radiation Biology and Related Studies

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“…Hollowell and Littlefeild [60] reported abscopal effects (lymphatic damaged chromosomes) in the untreated cells after they were kept in the plasma obtained from patients irradiated with X-ray. A year later Scott et al [61] confirmed these findings by observing chromosomal aberration in the lymphocytes exposed to the plasma of irradiated patients.…”

Section: Potential Detrimental and Beneficial Effects Of Radiation Inmentioning

confidence: 63%

Non-targeted effects of ionising radiation and radiotherapy

Sjostedt

Bezak

2010

Australas Phys Eng Sci Med

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Modern radiobiology is undergoing rapid change due to new discoveries contradicting the target concept which is currently used to predict dose-response relationships. Thus relatively recently discovered radiation-induced bystander effects (RIBEs), that include additional death, mutation and radio-adaptation in non-irradiated cells, change our understanding of the target concept and broadens its boundaries. This can be significant from a radioprotection point of view and also has the potential to reassess radiation damage models currently used in radiotherapy. This article reviews briefly the general concepts of RIBEs such as the proposed underlying mechanisms of signal induction and propagation, experimental approaches and biological end points used to investigate these phenomena. It also summarises several mathematical models currently proposed in an attempt to quantify RIBE. The main emphasis of this article is to review and highlight the potential impact of the bystander phenomena in radiotherapy.

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“…Some decrease in the average yield of dicentrics and rings was, however, reported by Scott, Sharpe, Batchelor, Evans and Papworth (1969) in cultures initiated 24 hours after irradiation and by Mello, Kwan and Norman (1974) when the incubation time before the addition of PHA was increased from zero to 120 hours . In both experiments blood was kept at a constant temperature of 37°C .…”

Section: Discussionmentioning

confidence: 88%