Radiation-induced chromosome aberrations and sister chromatid exchanges in lymphocytes from patients with tuberous sclerosis

Bleomycin-induced chromosomal damage in tuberous sclerosis

“…The spontaneous and MMC-induced SCE frequencies were also found to be within the normal range in TS patients (Iijima et al, 1985). The effect of gamma radiation on the induction of SCE and chromosome aberrations in unstimulated TS lymphocytes has recently been reported by Iijima et al (1988) who found no difference between SCE frequencies of TS lymphocytes and those of control lymphocytes, but chromosome aberrations in TS lymphocytes were significantly higher than those in the normal controls at a dose of 4 Gy, but not at lower doses. It seems likely that as high a dose as possible should be used in studies of this kind with the aim of stressing the system and unmasking any genomic instability (but the dose should also be compatible with obtaining sufficient number of mitotic cells for analysis).…”