Radiation-induced changes in regional blood flow in human tumors

Mäntylä, M; Toivanen, Jarmo; Pitkänen, Maunu; Rekonen, A

doi:10.1016/0360-3016(82)90291-7

Cited by 40 publications

(18 citation statements)

References 17 publications

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“…A similar initial increase followed by a significant decrease of blood flow was observed during the first few days after radiation therapy in patients with breast tumors. 64 In patients with head and neck tumors, 36,65 and rectal carcinoma, 66 similar patterns of blood flow changes were also reported in the early weeks after radiation therapy. Further studies involving more patients are underway to confirm the observations in this case study.…”

Section: Resultsmentioning

confidence: 60%

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

et al. 2007

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We combine diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment (day 7) DOS revealed significant changes in tumor/normal contrast compared to pretreatment (day 0) tissue concentrations of deoxyhemoglobin (rctHHb T/N =69±21%), oxyhemoglobin (rctO 2 Hb T/N =73±25%), total hemoglobin (rctTHb T/N =72±17%), and lipid concentration (rctLipid T/N =116±13%). Similarly, DCS found significant changes in tumor/normal blood flow contrast (rBF T/N =75±7% on day 7 with respect to day 0). Our observation suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms. Abstract. We combine diffuse optical spectroscopy ͑DOS͒ and diffuse correlation spectroscopy ͑DCS͒ to noninvasively monitor early hemodynamic response to neoadjuvant chemotherapy in a breast cancer patient. The potential for early treatment monitoring is demonstrated. Within the first week of treatment ͑day 7͒ DOS revealed significant changes in tumor/normal contrast compared to pretreatment ͑day 0͒ tissue concentrations of deoxyhemoglobin ͑rctHHb T/N = 69± 21% ͒, oxyhemoglobin ͑rctO 2 Hb T/N = 73± 25% ͒, total hemoglobin ͑rctTHb T/N = 72± 17% ͒, and lipid concentration ͑rctLipid T/N = 116± 13% ͒. Similarly, DCS found significant changes in tumor/ normal blood flow contrast ͑rBF T/N =75±7% on day 7 with respect to day 0͒. Our observations suggest the combination of DCS and DOS enhances treatment monitoring compared to either technique alone. The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms. © 2007 Society of Photo-Optical Instrumentation Engineers.

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Section: Resultsmentioning

confidence: 60%

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

et al. 2007

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“…It has been shown that vascularity and blood flow in tumours are inversely related to size and age (Cataland et al, 1962;Karlsson et al, 1980;Gullino & Grantham, 1961 (Jirtle, 1981;Groothuis et al, 1983). Furthermore, not all authors agree that tumour perfusion decreases significantly with growth (Mantyla, 1979;Groothuis et al, 1983). It can be seen from Figure 3 (Mathews, 1971) as described in the appendix.…”

Section: Discussionmentioning

confidence: 97%

Measurement of blood supply to murine tumours using in vivo red cell labelling and dynamic scintigraphy

Baker¹,

Clarke²,

Whimster³

1985

Br J Cancer

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Summary Blood pool and flow were studied in transplanted adenocarcinomas on the legs of mice. The animals' red blood cells were labelled in vivo by consecutive injections of a stannous compound and 99mTc-pertechnetate. The distribution of radioactivity was then recorded continuously with a gamma camera. This method allows prolonged and repeated estimations of blood supply to undisturbed tumours in conscious mice.It was found that in small tumours (under 1 ml) circulating blood pool was usually high, often 2 or 3 times that in normal leg tissues. In tumours bigger than 1 ml blood pool per unit volume tended to be lower but was still about 1.5 times the normal tissue level. This relatively large blood volume would seem to be outweighed by a very slow rate of flow. Even in the small tumours blood perfusion was greatly reduced compared to that in the normal leg. The blood pool results here provide no evidence that in tumours larger than 1 ml blood supply decreased progressively with growth.

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“…However, in these studies some well-oxygenated tumors failed to respond while some hypoxic tumors responded well, possibly due to the changes in tumor oxygen status during radiation treatment. Recent investigations using polarographic electrode, magnetic resonance imaging (MRI), dynamic computed tomography (CT) and 133 Xe clearance method have shown that tumor hemodynamic parameters changed over the period of radiation therapy and less-perfused tumors responded poorly [13–18]. Therefore, functional assessment of tumor oxygenation and blood flow changes during radiation therapy may help understand radiation pathology and holds potential for the prediction of therapy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery

Dong¹,

Kudrimoti²,

Cheng³

et al. 2012

Biomed. Opt. Express

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This study explored using a novel diffuse correlation spectroscopy (DCS) flow-oximeter to noninvasively monitor blood flow and oxygenation changes in head and neck tumors during radiation delivery. A fiber-optic probe connected to the DCS flow-oximeter was placed on the surface of the radiologically/clinically involved cervical lymph node. The DCS flow-oximeter in the treatment room was remotely operated by a computer in the control room. From the early measurements, abnormal signals were observed when the optical device was placed in close proximity to the radiation beams. Through phantom tests, the artifacts were shown to be caused by scattered x rays and consequentially avoided by moving the optical device away from the x-ray beams. Eleven patients with head and neck tumors were continually measured once a week over a treatment period of seven weeks, although there were some missing data due to the patient related events. Large inter-patient variations in tumor hemodynamic responses were observed during radiation delivery. A significant increase in tumor blood flow was observed at the first week of treatment, which may be a physiologic response to hypoxia created by radiation oxygen consumption. Only small and insignificant changes were found in tumor blood oxygenation, suggesting that oxygen utilizations in tumors during the short period of fractional radiation deliveries were either minimal or balanced by other effects such as blood flow regulation. Further investigations in a large patient population are needed to correlate the individual hemodynamic responses with the clinical outcomes for determining the prognostic value of optical measurements.

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Radiation-induced changes in regional blood flow in human tumors

Cited by 40 publications

References 17 publications

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy

Measurement of blood supply to murine tumours using in vivo red cell labelling and dynamic scintigraphy

Noninvasive diffuse optical monitoring of head and neck tumor blood flow and oxygenation during radiation delivery

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