Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment

Yang, Xiao; Ma, Linlin; Ye, Zhujing; Shi, Weihua; Zhang, Liyuan; Wang, Jingdong; Yang, Huiling

doi:10.1080/09553002.2021.1864498

Cited by 12 publications

(14 citation statements)

References 33 publications

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“…We previously observed a reduction in the proliferation and self-renewal ability of NSCs after co-culture with irradiated tumor cells [ 11 ], indicating that irradiated tumor cells could inhibit the proliferation and stemness of non-irradiated NSCs through medium-mediated bystander signaling. Here we examined whether irradiated bEnd.3 endothelial cells affected the cell proliferation and self-renewal ability of non-irradiated NSCs.…”

Section: Resultsmentioning

confidence: 99%

“…The results from Ivanov et al that irradiated neuroblastoma cells caused apoptosis and suppressed neuronal differentiation of non-irradiated NSCs suggested that irradiated cancer cells may inhibit neurogenesis via RIBEs [ 9 ]. Taking a further step by using an in vivo system, we clearly demonstrated that RIBEs may contribute to RIND since injection of exosomes from irradiated cancer cells into the hippocampus inhibited neurogenesis and caused cognitive impairment in the recipient mice [ 11 ]. Thus, the results we present here suggest that RIBEs of unexposed NSCs induced by irradiated endothelial cells may also contribute to RIND through neurogenesis inhibition.…”

Section: Discussionmentioning

confidence: 99%

“…The NSCs co-cultured with bEnd.3 cells for 72 h were re-seeded on poly-D-lysine-coated coverslips in 12-well plates and cultured at 37°C for 72 h in neuronal differentiation medium (DMEM/F12 containing penicillin-streptomycin (1%), B27 (2%), retinoic acid (5 mM) and FBS (0.5%)) and glial differentiation medium (DMEM/F12 containing penicillin-streptomycin (1%), B27 (2%), forskolin (5 mM) and FBS (1%)), respectively. As described [ 11 , 17 ], the cells were fixed and immunostained for Tuj1 and GFAP, respectively. The stained cells were photographed using a FV1200 fluorescence microscope.…”

Section: Methodsmentioning

confidence: 99%

“…In spite of the intensive study on RIBEs in the past 30 years, it still remains unclear what role RIBEs play in radiation-induced tissue injury. We have previously demonstrated that irradiated cancer cells can induce bystander effects in NSCs in turn contribute to neurogenesis inhibition and cognitive impairment, suggesting that RIBEs may be one of the mechanisms underlying RIND [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition

Zhang

et al. 2022

Journal of Radiation Research

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Radiation-induced neurocognitive dysfunction (RIND) has attracted a lot of attention lately due to the significant improvement of the survival of cancer patients after receiving cranial radiotherapy. The detailed mechanisms are not completely understood, but extensive evidence supports an involvement of the inhibition of hippocampal neurogenesis, which may result from radiation-induced depletion of neural stem cells (NSCs) as well as the damage to neurogenic niches. As an important component of neurogenic niches, vascular cells interact with NSCs through different signaling mechanisms, which is similar to the characteristics of radiation-induced bystander effect (RIBE). But whether RIBE is involved in neurogenesis inhibition contributed by the damaged vascular cells is unknown. Thus, the purpose of the present study was to investigate the occurrence of RIBEs in non-irradiated bystander NSCs induced by irradiated bEnd.3 vascular endothelial cells in a co-culture system. The results show that compared with the NSCs cultured alone, the properties of NSCs were significantly affected after co-culture with bEnd.3 cells, and further change was induced without obvious oxidative stress and apoptosis when bEnd.3 cells were irradiated, manifesting as a reduction in the proliferation, neurosphere-forming capability and differentiation potential of NSCs. All these results suggest that the damaged vascular endothelial cells may contribute to neurogenesis inhibition via inducing RIBEs in NSCs, thus leading to RIND.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition

Zhang

et al. 2022

Journal of Radiation Research

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“…Inhibition of neurogenesis due to IR-induced damage in neural stem cells (NSCs) is an important mechanism underlying long-term radiation-induced cognitive impairment [95,96]. After co-culture with GL261 glioma cells, mouse NSCs showed inhibition of proliferation and reduced neurosphere formation and differentiation potential.…”

Section: The Other Side Of the Coinmentioning

confidence: 99%

Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Fròsina

2021

IJMS

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Albeit the effort to develop targeted therapies for patients with high-grade gliomas (WHO grades III and IV) is evidenced by hundreds of current clinical trials, radiation remains one of the few effective therapeutic options for them. This review article analyzes the updates on the topic “radiotherapy of high-grade gliomas” during the period 1 January 2021–30 June 2021. The high number of articles retrieved in PubMed using the search terms (“gliom* and radio*”) and manually selected for relevance indicates the feverish research currently ongoing on the subject. During the last semester, significant advances were provided in both the preclinical and clinical settings concerning the diagnosis and prognosis of high-grade gliomas, their radioresistance, and the inevitable side effects of their treatment with radiation. The novel information concerning tumor radiosensitization was of special interest in terms of therapeutic perspective and was discussed in detail.

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Ionizing radiation toxicology

Danforth¹,

Pearson²,

Goodarzi³

2024

Encyclopedia of Toxicology

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Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment

Cited by 12 publications

References 33 publications

Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition

Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition

Radiotherapy of High-Grade Gliomas: First Half of 2021 Update with Special Reference to Radiosensitization Studies

Ionizing radiation toxicology

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