Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study

Cai, Zhaoxi; Li, Yang; Hu, Zhen; Fu, Ruying; Rong, Xiaoming; Wu, Rong; Cheng, Jinping; Huang, Xiaolong; Luo, Jin Jun; Tang, Yamei

doi:10.18632/oncotarget.7748

Cited by 29 publications

(27 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the availability of Magnetic resonance neurography (multiplanar T2‐based sequences with fat suppression) has allowed a better evaluation of specific nerve morphological features (such as caliber, internal fascicular pattern and the amount of perineurial‐endoneurial fluid), thus implementing the conventional MRI where injured plexus showed hypertense and enhanced signal. Additional radiological hints of post‐radiation plexopathy may be found in the surrounding tissues . The implementation of magnetic resonance neurography with diffusion‐weighted sequences appears promising in the investigation of cancer patient .…”

Section: Plexopathiesmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

View full text Add to dashboard Cite

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune‐mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Some clinical findings, such a focal or diffuse involvement, symmetric or asymmetric pattern, presence of pain may point to the correct diagnosis. Besides a thorough medical history and neurological examination, neurophysiological studies, cerebrospinal fluid analysis, nerve biopsy (in selected patients with suspected lymphomatous infiltration) and neuroimaging techniques (magnetic resonance neurography and nerve ultrasound) may be crucial for a proper diagnostic workup.

show abstract

Section: Plexopathiesmentioning

confidence: 99%

“…Additional radiological hints of post-radiation plexopathy may be found in the surrounding tissues. 87,88 The implementation of magnetic resonance neurography with diffusion-weighted sequences appears promising in the investigation of cancer patient. 65,89 In addition, 18-FDG PET may have a supplemental role in ruling out malignancy.…”

Section: Plexopathiesmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

View full text Add to dashboard Cite

show abstract

“…Similarly, in radiation plexopathy, which can develop from a few months to many years after radiotherapy, MRN reveals diffuse hypertrophy of the brachial plexus, the extent of which closely correlates with the extent of radiation received, visible as an increase in signal intensity without contrast enhancement 68 . By contrast, neoplastic infiltration of the brachial plexus is characterized by focal or diffuse mass lesion with marked contrast enhancement 69 .…”

Section: Nontraumatic Brachial Plexopathiesmentioning

confidence: 98%

New technologies for the assessment of neuropathies

et al. 2017

View full text Add to dashboard Cite

Peripheral neuropathies are among the most common neurological disorders 1 . In routine clinical practice, diagnosis of peripheral neuropathies is typically based on clinical assessment, nerve conduction studies and needle electromyography, which can determine whether symptoms are caused by primary axonal damage or demyelinating damage. This distinction is often relevant to therapeutic choices and to prognosis, as axonal damage typically reflects an inflammatory (for example, vasculitic) or degenerative (for example, hereditary or idiopathic) process that correlates with disability, whereas demyelinating damage can reflect a hereditary neuro pathy, but more often reflects an acquired immunemediated neuropathy. Besides metabolic, inflammatory or primary degenerative neuropathies, peripheral nerves can also be damaged by compression from adjacent tissue structures, such as tendons, cysts or haematomas. In this case, proper identification of the site, nature and degree of the lesion might be challenging, but is relevant to treatment and prognosis. Moreover, some patients present with symptoms that suggest damage to small nerve fibres, which nerve conduction studies cannot be used to detect.In the past 15 years, several techniques have become available to investigate focal and diffuse peripheral neuropathies, and their reliability has widened the spectrum of diagnostic tools for clinicians and improved assessment of neuropathies. In this Review, we provide an overview of these new and emerging technologies. We first discuss peripheral nerve imaging with MRI and ultrasonography, which can provide information about the precise localization of neuro pathies and the pathological processes involved in large-fibre neuropathies, and can complement clinical and electrophysiological evaluation. We then consider techniques that can provide diagnostic information when the pathological process is restricted to small nerve fibres and is consequently not detectable with nerve conduction studies or neuroimaging. These include skin biopsy, which is established in clinical practice, and the emerging techniques of corneal confocal microscopy, laser-evoked potentials and heat-related and pain-related evoked potentials, and microneurography.Nerve imaging technology Advances in imaging techniques have made it possible to gain great insight into nerve pathology with magnetic resonance and ultrasound. Each approach offers distinct advantages, and can provide different information about damage to large myelinated fibres. Abstract | Technical advances are rapidly changing the clinical and instrumental approach to peripheral nerve diseases. Magnetic resonance neurography, diffusion tensor imaging and nerve ultrasonography are increasingly entering the diagnostic workup of peripheral neuropathies as tools that complement neurophysiology and enable investigation of proximal structures, such as plexuses and roots. Progress in the design of magnetic resonance scanners and sequences, and the development of high-frequency ultrasound probes mean th...

show abstract

“…Radiation induced brachial plexus damage in oncological patients is another not uncommon clinical scenario (51). In spite of new modulated radiation therapy techniques for head and neck or breast cancer treatment, post-radiotherapy brachial plexus neuropathy has to be considered when oncological patients with suspicion of brachial plexus involvement are evaluated (Figure 8).…”

mentioning

confidence: 99%

Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries

Noguerol¹,

Barousse²,

Socolovsky

et al. 2017

Quant. Imaging Med. Surg.

View full text Add to dashboard Cite

Traumatic conditions of peripheral nerves and plexus have been classically evaluated by morphological imaging techniques and electrophysiological tests. New magnetic resonance imaging (MRI) studies based on 3D fat-suppressed techniques are providing high accuracy for peripheral nerve injury evaluation from a qualitative point of view. However, these techniques do not provide quantitative information. Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) are functional MRI techniques that are able to evaluate and quantify the movement of water molecules within different biological structures. These techniques have been successfully applied in other anatomical areas, especially in the assessment of central nervous system, and now are being imported, with promising results for peripheral nerve and plexus evaluation. DWI and DTI allow performing a qualitative and quantitative peripheral nerve analysis, providing valuable pathophysiological information about functional integrity of these structures.In the field of trauma and peripheral nerve or plexus injury, several derived parameters from DWI and DTI studies such as apparent diffusion coefficient (ADC) or fractional anisotropy (FA) among others, can be used as potential biomarkers of neural damage providing information about fiber organization, axonal flow or myelin integrity. A proper knowledge of physical basis of these techniques and their limitations is important for an optimal interpretation of the imaging findings and derived data. In this paper, a comprehensive review of the potential applications of DWI and DTI neurographic studies is performed with a focus on traumatic conditions, including main nerve entrapment syndromes in both peripheral nerves and brachial or lumbar plexus.

show abstract

Radiation-induced brachial plexopathy in patients with nasopharyngeal carcinoma: a retrospective study

Cited by 29 publications

References 34 publications

Peripheral nervous system involvement in lymphomas

Peripheral nervous system involvement in lymphomas

New technologies for the assessment of neuropathies

Quantitative magnetic resonance (MR) neurography for evaluation of peripheral nerves and plexus injuries

Contact Info

Product

Resources

About