Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation

Takahashi, Akio; Asakawa, Isao; Yuki, Kazue; Matsumoto, Tsuneya; Kumamoto, Makiko; Kondo, Natsuko; Ohnishi, Ken; Tachibana, Akira; Ohnishi, Takeo

doi:10.1080/09553000210132306

Cited by 35 publications

(11 citation statements)

References 27 publications

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“…Further, although apoptosis was not investigated in this study, it is possible that BM cells of SCID/J mice are capable of removing some of the damaged cells by means of apoptosis. The non-harmful effects of low doses and low dose-rates of low LET radiation via apoptosis have previously been reported in the spleen of SCID mice [54,55]. In those studies, a role for p53 proteins in apoptosis induced by low dose or low dose-rate of low LET radiation has been suggested.…”

Section: Resultsmentioning

confidence: 94%

Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation

Rithidech

Udomtanakunchai

Honikel

et al. 2013

IJERPH

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It is clear that high-dose radiation is harmful. However, despite extensive research, assessment of potential health-risks associated with exposure to low-dose radiation (at doses below or equal to 0.1 Gy) is still challenging. Recently, we reported that 0.05 Gy of 137Cs gamma rays (the existing limit for radiation-exposure in the workplace) was incapable of inducing significant in vivo genomic instability (measured by the presence of late-occurring chromosomal damage at 6 months post-irradiation) in bone marrow (BM) cells of two mouse strains, one with constitutively high and one with intermediate levels of the repair enzyme DNA-dependent protein-kinase catalytic-subunit (DNA-PKcs). In this study, we present evidence for a lack of genomic instability in BM cells of the severely combined-immunodeficiency (SCID/J) mouse (which has an extremely low-level of DNA-PKcs activity) exposed whole-body to low-dose radiation (0.05 Gy). Together with our previous report, the data indicate that low-dose radiation (0.05 Gy) is incapable of inducing genomic instability in vivo (regardless of the levels of DNA-PKcs activity of the exposed mice), yet higher doses of radiation (0.1 and 1 Gy) do induce genomic instability in mice with intermediate and extremely low-levels of DNA-PKcs activity (indicating an important role of DNA-PKcs in DNA repair).

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Section: Resultsmentioning

confidence: 94%

Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation

Rithidech

Udomtanakunchai

Honikel

et al. 2013

IJERPH

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“…In this sense, it has been reported that DNA-dependent proteinkinases activity might play an important role in the radioadaptive response. This mechanism might be due to the suppression of p53-mediated apoptosis (Takahashi et al , 2002.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of radioadaptive response induced in CHO-K1 cells in a non-traditional model

Grillo

Dulout

Güerci

2009

International Journal of Radiation Biology

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“…Because time is required for these processes, an interval between low‐dose irradiation and subsequent high‐dose irradiation is necessary to achieve radioresistance. Many factors contribute to the adaptive response in each process, as summarized in Table 3 40,43,50–65 …”

Section: Adaptive Response To Oxidative Stress and Agingmentioning

confidence: 99%

Survival responses to oxidative stress and aging

Miura¹,

Endo²

2010

Geriatrics Gerontology Int

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Oxidative stress is recognized as an important environmental factor in aging; however, because reactive oxygen species (ROS) and related free radicals are normally produced both intra-and extracellularly, air-living organisms cannot avoid the risk of oxidative stress. Consequently, these organisms have evolved various anti-oxidant systems to prevent ROS, scavenge free radicals, repair damaged components and adaptive responses. This review will focus on the repair and adaptive response to oxidative stress, and summarize the changes of these systems as a result aging and their relationship to premature aging. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S1-S9.

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Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation

Abstract: These data suggest that DNA-PK activity might play a major role in the radioadaptive response following pre-irradiation at a low dose-rate.

Cited by 35 publications

References 27 publications

Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation

Lack of Genomic Instability in Bone Marrow Cells of SCID Mice Exposed Whole-Body to Low-Dose Radiation

Evaluation of radioadaptive response induced in CHO-K1 cells in a non-traditional model

Survival responses to oxidative stress and aging

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