Radiation-induced angiosarcoma (RIAS) of the maxilla: a case report

Abstract

Angiosarcoma is a rare malignant mesenchymal tumor of vascular or lymphatic origin and represents less than 1% of all malignant tumors. Radiation therapy is a standard treatment in many head and neck cancer cases, but ionizing radiation is associated with radiation carcinogenesis including radiation-induced angiosarcoma. In this article, we report a rare case of radiation-induced angiosarcoma found in a 58-year-old female patient who was previously diagnosed with an odontogenic keratocyst and mucoepidermoid carcinoma.

When Radiation Therapy Becomes a Foe: A Rare Case of Radiation-Induced Angiosarcoma of Head and Neck

“…Two strong risk factors linked to the development of angiosarcoma included chronic lymphedema and prior radiation therapy, as seen in our patient. In addition, they more commonly affect the elderly and are twice as likely to occur in males than females [6].…”

“…Two strong risk factors linked to the development of angiosarcoma included chronic lymphedema and prior radiation therapy, as seen in our patient. In addition, they more commonly affect the elderly and are twice as likely to occur in males than females [ 6 ]. Frequently noted locations include cutaneous scalp lesions in elderly white men as well as in cancer locations treated with radiation, the most notable being breast cancer and lymphomas [ 7 ].…”