RADIATION HYPOPHYSECTOMY WITH HIGH-ENERGY PROTON BEAMS. Preliminary Report

Tobias, Cornelius A.; Roberts, John Η.; Lawrence, John H.; Low‐Beer, B. V. A.; Anger, Hal O.; Born, James L.; McCombs, Rollin K.; Huggins, Charles

doi:10.2172/4374210

Cited by 45 publications

(45 citation statements)

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“…After completion of the 184.-inch Synchrocyclotron at the University of California at Berkeley -Lawrence Berkeley Laboratory (UCB-LBL) in 1947 [2], Tobias et al [3,4,5] began the study of the biologic effects of narrow beams of protons, deuterons and helium ions, with emphasis on reaction to radiation injury in the brain. The first clinical trials using charged particles were begun in 1954 by Lawrence, Tobias and their colleagues [6,7,8,9] for the pituitary-hormone suppression treatment of patients with metastatic breast carcinoma. Since then, stereotactically directed focal charged-particle pituitary radiosurgery has been used at UCB-LBL to treat 840 patients ( Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…In the earlier years of the program, patients with vario.us disorders underwent treatment to effect hormonal suppression of disease by induction of hypopituitarism; this included 183 patients with metastatic breast carcinoma and 169 patients with diabetic retinopathy, as well as selected patients with prostatic carcinoma and other adenohypophyseal hormoneresponsive malignancies (Table 1) [6,7,8,9,10,11,12]. In 1958, the charged-particle radiosurgery program was expanded to include patients with endocrine and metabolic disorders of the pituitary gland, i.e., acromegaly, Cushing's disease, Nelson's syndrome, prolactinsecreting adenomas and chromophobe adenomas [8,11,13,14,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Heavy-Charged-Particle Radiosurgery of the Pituitary Gland: Clinical Results of 840 Patients

Levy

Fabrikant

Frankel

et al. 1991

Stereotact Funct Neurosurg

119

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Since 1954, 840 patients have been treated at Lawrence Berkeley Laboratory with stereotactic charged-particle radiosurgery of the pituitary gland. The initial 30 patients were treated with proton beams; the subsequent 810 patients were treated with helium ion beams. In the great majority of the 475 patients treated for pituitary tumors, marked and sustained biochemical and clinical improvement was observed. Variable degrees of hypopituitarism developed in about one-third of patients treated solely with radiosurgery. In the earlier years of the program, 365 patients underwent radiosurgery to treat selected systemic diseases by inducing hypopituitarism. Focal temporal lobe necrosis and cranial nerve injury occurred in about 1% of patients who were treated with doses less than 230 Gy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heavy-Charged-Particle Radiosurgery of the Pituitary Gland: Clinical Results of 840 Patients

Levy

Fabrikant

Frankel

et al. 1991

Stereotact Funct Neurosurg

119

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“…pikiem Bragga). Zaledwie w 8 lat po propozycji R. R.Wilsona, w 1954 roku zespół Corneliusa A. Tobiasa przeprowadził radioterapię protonową u pierwszego pacjenta [5,6]. Według danych Particle Therapy Co-Operative Group (PTCOG) do końca 2012 roku radioterapię protonową przeprowadzono u 93 895 chorych w różnych ośrodkach na świecie, w tym w Europie -u 31 962 chorych.…”

Section: Odkrycie Nuklidów I Powstanie Radioterapii Hadronowejunclassified

Radioterapia hadronowa w Krakowie — przeszłość, teraźniejszość i przyszłość

Sas-Korczyńska¹,

Walasek²,

Romanowska–Dixon³

2014

Nowotwory. Journal of Oncology

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"… czas przemijający, doświadczenie złudne, wyrokowanie trudne…"Hippokrates AforyzmyPanu Profesorowi Janowi Skołyszewskiemu, Mistrzowi sztuki leczenia chorych, pracy naukowej i interdyscyplinarnej współpracy, powyższą pracę dedykują wdzięczni uczniowie -autorzy W obecnym opracowaniu omówiono w skrócie definicje i historię odkrycia niektórych hadronów (protonu i neutronu) oraz przesłanki i wskazania kliniczne do radioterapii hadronowej. Przedstawiono dotychczasowe doświadczenia krakowskiego ośrodka w stosowaniu radioterapii neutronowej (w latach 1978-1995) i radioterapii protonowej (stosowanej od 2011 roku) oraz perspektywy dalszego rozwoju. Hadron radiotherapy in Kraków -past, present and futureThe definition and discovery of some hadrons (protons and neutrons) and the rationale and clinical indications for hadron radiotherapy are presented in this paper. The authors describe the Kraków experience in the clinical use of neutron radiotherapy for the period 1978-1995 and the use of proton radiotherapy since 2011. The perspectives for progress for this method of radiotherapy is presented.Słowa kluczowe: hadron, radioterapia neutronowa, radioterapia protonowa Key words: hadron, neutron radiotherapy, proton radiotherapy NOWOTWORY Journal of Oncology 2014; 64, 3: 251-257 Radioterapia hadronowa -definicja, historia, przesłanki i wskazania kliniczne W radioterapii hadronowej wykorzystywane są cząstki (tzw. hadrony), które charakteryzują silne oddziaływania, ładunek elektryczny oraz liczba barionowa. Obecnie fizyka cząstek elementarnych wyróżnia dwa rodzaje hadronów: bariony (zbudowane z 3 kwarków, posiadające połówkowy spin) oraz mezony (o spinie całkowitym, zbudowane z 2 kwarków). W radioterapii zastosowanie znalazły: z pierwszej grupy -nukleony, czyli protony i neutrony, a z drugiej -piony (p -).

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“…The heavy charged particle beams from the 184-incb Synchrocyclotron and the Bevatron at the Lawrence Berkeley Laboratory (LBL) have now been used to treat a number of brain disorders, including pituitary tumors and other neurometabolic disorders [16], to suppress pituitary function in metastatic breast cancer and diabetic retinal angiopathy [17] [8] [9], intracranial AVMs [3] [4] and uveal melanomas [13].…”

Section: Introductionmentioning

confidence: 99%