We continue our series of studies of high-energy collisions of black holes investigating unequalmass, boosted head-on collisions in four dimensions. We show that the fraction of the center-of-mass energy radiated as gravitational waves becomes independent of mass ratio and approximately equal to 13% at large energies. We support this conclusion with calculations using black hole perturbation theory and Smarr's zero-frequency limit approximation. These results lend strong support to the conjecture that the detailed structure of the colliding objects is irrelevant at high energies. Introduction. Numerical simulations of black hole (BH) collisions are an ideal framework to understand the behavior of gravity in the strong-field regime. These simulations allow us to answer fundamental questions and to verify (or disprove) some of our cherished beliefs about Einstein's general relativity (GR). Are BH collisions subject to cosmic censorship, so that naked singularities are never the outcome of any such event? What is the upper limit of the fraction of kinetic energy of the system that can be radiated in gravitational waves (GWs) during these collisions? In the ultrarelativistic (UR) limit, what properties of the collision, if any, are dependent on the underlying structure of the colliding objects, here the spins of the BHs and their mass ratio?Some years ago we started a long-term program to answer these questions. We first showed that the head-on collision of two equal-mass BHs at the speed of light will radiate no more than ∼ 14 ± 3% of the energy of the system [1] (this result was recently confirmed independently by the RIT group [2], refining the limit to 13 ± 1%). This is less than half the upper limit of ∼ 29% predicted by Penrose in the seventies, but two orders of magnitude larger than the energy radiated when two BHs collide head-on from rest [3]. We found that collisions with finite impact parameter can be tuned to exhibit "zoomwhirl" behavior [4,5] and that they can produce nearmaximally spinning remnants [6]. We also used zerofrequency limit (ZFL) calculations pioneered by Smarr [7] and BH perturbation theory to clarify the structure of the radiation [8]. We studied grazing collisions with aligned