Radiation exposure to family members of patients with thyrotoxicosis treated with iodine-131

Cappelen, Tone; Unhjem, Jan Frede; Amundsen, Anne Lise; Kravdal, Gunnhild; Følling, Ivar

doi:10.1007/s00259-005-1888-7

Cited by 28 publications

(17 citation statements)

References 10 publications

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“…There have been reports of family members who received radiation doses greater than the safety level [5,7]; however, there has been no report of any patient who developed a thyroid malignancy after third-party iodine-131 exposure. Although strong cause-effect relationship could not be demonstrated on a single-case evidence, our reported case emphasizes that care should be taken in giving ambulatory radioactive iodine therapy to a patient having young family members.…”

Section: Discussionmentioning

confidence: 89%

“…A multicenter study of outpatient radioiodine therapy in UK found that 6 of 17 family members aged 3 years or younger who were children of the patients received radiation at an adjusted dose of more than 1 mSv, while almost all adult family members received an adjusted dose within the safety limits [5]. A recent case series from Norway also reported one 2-year-old child who absorbed a radiation dose of 3.04 mSv from the mother despite repeatedly being informed of the safety instructions [7]. It should be noted that the mother of the latter case received only 260 MBq of radioactive iodine, which was comparable with the mother of our patient.…”

Section: Discussionmentioning

confidence: 92%

“…Although emission of radiation from the patient can potentially affect surrounding people, various studies have determined that administration of the treatment is safe and can be done on an ambulatory basis [4][5][6][7]. Many countries, including the USA, UK and some European countries, offer outpatient treatment with advice given to minimize subsequent close contact with other individuals [4,5,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Papillary carcinoma of the thyroid gland in a child of thyrotoxicosis patient receiving radioactive iodine therapy: report of a case

et al. 2008

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Herein we present the case of a 9-year-old girl who had an enlarged right lobe of the thyroid gland and sub-clinical hypothyroidism (thyroid stimulating hormone at 9.24 mIU/L). The patient had a history of unintentional exposure to radiation while her mother was receiving radionuclide therapy for diffuse toxic goiter. Ultrasonography of the young girl showed right lobe enlargement with diffuse coarse heterogenous echogenicity, compatible with a microcalcification pattern identified in both lobes of the thyroid gland. Histopathology of the tissue from a thyroidectomy revealed papillary thyroid carcinoma in the right lobe and chronic lymphocytic thyroiditis in the remaining tissue. Molecular pathology demonstrated an RET/PTC1 rearrangement in both tumor and non-tumorous tissue harboring thyroiditis. Considering the history of exposure and the characteristics of the thyroid pathology together, the PTC in this patient was likely a secondary-to-genetic alteration induced by external radiation. This case emphasizes the importance of stringent restrictions when giving radioactive iodine therapy to a patient with small children.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Papillary carcinoma of the thyroid gland in a child of thyrotoxicosis patient receiving radioactive iodine therapy: report of a case

et al. 2008

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“…10 -14 Similar results were reported in other studies on hyperthyroidism or thyroid cancer outpatient treatment, with all reported mean values attaining less than 1.0 mSv. [15][16][17][18][19] Although caregiver thyroid glands were not surveyed with a radiation detector in this study, radiation exposure from contamination or radioiodine intake seems to have been much lower than external exposure. This was also shown by other researchers, 19,20 -22 and thoroughly discussed in a previous study by our group.…”

Section: Discussionmentioning

confidence: 99%

Outpatient Radioiodine Therapy for Thyroid Cancer

Willegaignon¹,

Sapienza²,

Ono³

et al. 2011

Clinical Nuclear Medicine

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“…Table 1 concludes that in all studies the excretion rate of 131 I activity from patients is more than 75% within 72 hours of activity administration. Figure 1 shows the Table 2 shows the radiation dose levels to family members/ caregivers of radioiodine patient which pointed out that the doses to masses in various studies [4,[30][31][32][33][34][35][36][37][38] including current report were in the magnitude of annual limit to general public (1mSv) which wrapping up that the patients treated with 131 I do not share a significant radiation dose to the public [4,16,39]. Table 3 presents the data of patients' stay at hospital including current study.…”

Section: Discussionmentioning

confidence: 99%

Isolation Period of 131I Administered Patients at NIMRA Jamshoro Pakistan

Memon

Laghari

Mangi

et al. 2017

IJRRT

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Objectives: Since 1940s, the clinical use of unsealed radioisotopes has been in practice and after that the radioiodine's oral administration became a gold standard for treating thyroid cancers. To protect the patients' family members/ caregivers and general public from unacceptably high radiation exposures, the therapeutic dosage of 131 I administered patients are mandatory hospitalized in special isolation room until the exposure rate at one meter meets international and national limits. The current study was focused to measure the isolation duration of inpatients treated with radioiodine. Material and methods:The current study presents the duration of hospitalization of patients treated with 131 I therapeutic dosages at Nuclear Institute of Medicine & Radiotherapy (NIMRA) Jamshoro, Pakistan from 2011 to 2013. Thirty Five patients (age range from 18 to 70 years) with cancer of thyroid administered with different activities (50 to 200 mCi (milliCurie)) of 131 I admitted in special isolated room at different times were included in this study. Results:The results indicated that only one (2.86%) of total patients discharged from hospital within first 24 hours of 131 I administration whereas 17(48.57%), 11(31.43%) and 3(8.57%) patients were hospitalized in isolation room for 48, 72 and 96 hours after the administration of activity. Eleven percent of total isolated patients (n=4) stayed for 120 to 144 hours at the hospital. Conclusion:The stay duration of 131 I administered patients at NIMRA shows wide-ranging pattern. Due to rapid clearance of radioiodine form their bodies, more than half of patients stayed only 48 hours.

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Radiation exposure to family members of patients with thyrotoxicosis treated with iodine-131

Cited by 28 publications

References 10 publications

Papillary carcinoma of the thyroid gland in a child of thyrotoxicosis patient receiving radioactive iodine therapy: report of a case

Papillary carcinoma of the thyroid gland in a child of thyrotoxicosis patient receiving radioactive iodine therapy: report of a case

Outpatient Radioiodine Therapy for Thyroid Cancer

Isolation Period of 131I Administered Patients at NIMRA Jamshoro Pakistan

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