Radiation development of gastroretentive amoxicillin trihydrate floating-alginate based beads for the treatment of helicobacter pylori

Raafat, Amany I.; Kamal, H.; Sharada, Hayat M.; elhalim, Sawsan A. Abd; Mohamed, Randa D.

doi:10.1016/j.radphyschem.2020.109268

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…Alginat adalah polisakarida linear hidrofilik yang dapat diekstraksi dari alga coklat seperti Macrocystis pyrifera, Ascophyllum nodosum, dan Laminaria hyperborean, atau diisolasi dari spesies bakteri seperti Azotobacter dan Pseudomonas [37][38][39] . Alginat tersusun oleh dua asam uronat yaitu α-L-asam guluronat (blok G) dan β-D-asam manuronat (blok M) yang dihubungkan melalui ikatan 1,4-glikosidik [40][41][42][43] , yang merupakan suatu gugus karboksilat dari asam uronat. Muatan negatif dari gugus karboksil dapat diikat silang dengan kation divalen seperti Ca 2+ , Zn 2+ , dan lainlain [3,33,37] .…”

Section: Alginatunclassified

“…Pada pH rendah, alginat terprotonasi menjadi bentuk asam alginat yang tidak larut, sehingga menunjukkan sifat pembengkakan yang menjelaskan jumlah pelepasan obat yang rendah [41,42] . Selain itu, adanya interaksi ikatan hidrogen yang lebih kuat diantara gugus karboksil menghasilkan saluran lebih kecil untuk difusi obat [43] . Dalam enkapsulasi zat aktif, konsentrasi alginat berperan penting untuk meningkatkan efisiensi enkapsulasi.…”

Section: Alginatunclassified

“…Dalam enkapsulasi zat aktif, konsentrasi alginat berperan penting untuk meningkatkan efisiensi enkapsulasi. Meningkatnya konsentrasi alginat dapat menurunkan efisiensi enkapsulasi [43] .…”

Section: Alginatunclassified

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Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

Marvita¹,

Chaerunisaa²,

Sopyan³

2021

Maj. Farmasetika

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Obat merupakan zat aktif yang bersifat asam atau basa. Beberapa zat aktif memiliki stabilitas yang rendah dan pelepasan obat yang kurang terkontrol. Masalah ini dapat diatasi dengan mengenkapsulasi zat aktif tersebut menggunakan polimer bersifat biodegradable, salah satunya polimer golongan polisakarida yang telah banyak digunakan seperti alginat, kitosan, pektin, dan selulosa. Enkapsulasi zat aktif telah menghasilkan banyak sifat penting seperti penghantaran obat lepas lambat atau terkontrol, peningkatan stabilitas, dan peningkatan bioavailabilitas sehingga dapat meningkatkan kesesuaian untuk aplikasinya. Artikel ini dibuat dengan menggunakan metode pencarian referensi secara online yang berasal dari free database “sciencedirect.com” dari tahun 2012 – 2021. Artikel ini akan membahas beberapa penggunaan polimer golongan polisakarida untuk ekapsulasi zat aktif dengan perbedaan sifat keasaman. Berdasarkan beberapa data penelitian yang terkumpul, membuktikan keberhasilan polimer polisakarida dalam mengenkapsulasi zat aktif yang bersifat asam dan basa. Parameter keberhasilan yang dinilai dalam artikel ini untuk enkapsulasi zat aktif adalah nilai efisiensi enkapsulasi dan pelepasan obat. Zat aktif yang bersifat asam cenderung memiliki efisiensi enkapsulasi yang lebih tinggi daripada zat aktif bersifat basa. Namun, tidak memberikan perbedaan pelepasan obat pada kondisi cairan lambung dan cairan usus. Zat aktif dengan sifat keasaman yang berbeda sama-sama memiliki pelepasan obat tertinggi pada kondisi basa.

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Section: Alginatunclassified

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Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

Marvita¹,

Chaerunisaa²,

Sopyan³

2021

Maj. Farmasetika

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“…The current study investigates the synthesis of a series of homopolymeric and copolymeric injectable hydrogels based on PEGMEM and DMAEM for their use in cartilage regeneration. Both monomers have been reported to be used for several biomedical applications [ 27 , 28 , 29 , 30 ]; however, the safety of polymers based on DMAEM is still controversial [ 31 , 32 , 33 ]. The previously described synthesis procedure [ 26 ] was modified to obtain more flowable hydrogel to fulfill the injectability requirement.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage

Farrag,

Ait Eldjoudi,

Farrag

et al. 2023

Polymers

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Here, we present the synthesis of a series of chemical homopolymeric and copolymeric injectable hydrogels based on polyethylene glycol methyl ether methacrylate (PEGMEM) alone or with 2-dimethylamino ethyl methacrylate (DMAEM). The objective of this study was to investigate how the modification of hydrogel components influences the swelling, rheological attributes, and in vitro biocompatibility of the hydrogels. The hydrogels’ networks were formed via free radical polymerization, as assured by 1H nuclear magnetic resonance spectroscopy (1H NMR). The swelling of the hydrogels directly correlated with the monomer and the catalyst amounts, in addition to the molecular weight of the monomer. Rheological analysis revealed that most of the synthesized hydrogels had viscoelastic and shear-thinning properties. The storage modulus and the viscosity increased by increasing the monomer and the crosslinker fraction but decreased by increasing the catalyst. MTT analysis showed no potential toxicity of the homopolymeric hydrogels, whereas the copolymeric hydrogels were toxic only at high DMEAM concentrations. The crosslinker polyethylene glycol dimethacrylate (PEGDMA) induced inflammation in ATDC5 cells, as detected by the significant increase in nitric oxide synthase type II activity. The results suggest a range of highly tunable homopolymeric and copolymeric hydrogels as candidates for cartilage regeneration.

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“…ATH is likely to be a white powder, and when given orally [5], it is well absorbed based on its physical, chemical, and biopharmaceutical constraints. Earlier studies have proved that ATH is effective in contradiction of H. pylori [6,7], but its less retention time in the stomach, makes the treatment less effective [6,8]. So an innovative attempt was made to retain ATH by formulating it as mucoadhesive microspheres.…”

Section: Introductionmentioning

confidence: 99%

Plant Gum Aided Mucoadhesive Microspheres to Eradicate Helicobacter pylori and Its Optimization with Design-Expert's Central Composite Design

Mundarinti¹,

Ahad²

2022

app

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Aim: The aim of the work was to explore the mucoadhesive properties of Mastic gum by involving it in mucoadhesive microspheres with Amoxicillin Trihydrate as a model drug. Using Carbopol-934P and varying amounts of Mastic gum. Methods: 9 interpretations of mucoadhesive microspheres were made by using Design expert software. A central composite design was applied to test the impact of independent variables (Carbopol-934P and mastic gum levels) on drug released at 10h and mucoadhesive strength as the response. Results: A congeniality and physical exam was conducted on the microspheres to see if Amoxicillin Trihydrate (ATH) was present, including its liberation. In formulations that contain lower levels of MG, mucoadhesion strength increased and drug released at the end of 10h was greater. Conclusion: Since MG acts as a release retardant, the amount of drug released is slightly reduced when higher levels are present in formulations. ATH gastro retention for eradicating with Mastic gum aided mucoadhesion (as this gum is proven H. pylori activity) is capable of completely capturing the gastrointestinal tract and effectively delivering the medication to the stomach.

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Radiation development of gastroretentive amoxicillin trihydrate floating-alginate based beads for the treatment of helicobacter pylori

Cited by 10 publications

References 42 publications

Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

Penggunaan Polimer Golongan Polisakarida untuk Enkapsulasi Zat Aktif dengan Perbedaan Sifat Keasaman

Poly(ethylene Glycol) Methyl Ether Methacrylate-Based Injectable Hydrogels: Swelling, Rheological, and In Vitro Biocompatibility Properties with ATDC5 Chondrogenic Lineage

Plant Gum Aided Mucoadhesive Microspheres to Eradicate Helicobacter pylori and Its Optimization with Design-Expert's Central Composite Design

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