Radiation Damage in Biomolecules and Cells

Carante, Mario Pietro; Ballarini, F.

doi:10.3390/ijms21218188

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…This detector's sheet was cut into small pieces (1cm 2 areas each). It is encased in plastic on both sides, and this plastic is removed when it is used to protect it from radiological background 2 . Because of its sensitivity, such a detector can detect alphas tracks at low energy levels 15 .…”

Section: Urinementioning

confidence: 99%

“…Human exposes to ionizing radiation from natural sources and sometimes from synthetic sources that come from human activities. The dangerous effect of ionizing radiation is the biological damage to Deoxyribonucleic Acid (DNA) or another part of the body 2 . The Types of radiation that effects human health is alpha, beta, gamma, neutron, and gamma rays, and each radiation has different properties 2 .…”

Section: Introductionmentioning

confidence: 99%

“…The dangerous effect of ionizing radiation is the biological damage to Deoxyribonucleic Acid (DNA) or another part of the body 2 . The Types of radiation that effects human health is alpha, beta, gamma, neutron, and gamma rays, and each radiation has different properties 2 . The exposure to radiation from the radioactive nuclides can be divided into external and internal exposure; in general, for example, external exposure come from direct gamma ray, while mostly the interior exposure is result from the inhalation of radon and thoron with their other short life decay products 3 .…”

Section: Introductionmentioning

confidence: 99%

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Alpha Tracks Examination for Female Urine Samples who are Suffering from Urinary Tract Infections

Mohammed¹,

Obaid

Abbas

et al. 2023

Baghdad Sci.J

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Urine samples had been gathered from females living in Baghdad city. The sample consisted of 30 females who suffered from U.T.I (Urinary tract infections) and 20 healthy females. The type of urine U.T.I was specified by the emergency lab in Al-Kindy hospital, and alpha tracks were determined by the nuclear track detector CR-39. The concentrations of alpha in 30 urine samples taken from females who had U.T.I ranged from 0.327ppm-1.583ppm, with an average of 0.94965 ppm. The maximum value 1.583 ppm is belonging to females with an aged 57 years old. The results of healthy female concentration ranged from 0.022 ppm-0.459ppm with an average of (0.30855ppm). The findings revealed that alpha emitter concentrations differed from woman to woman, depending on the degree to which women's bodies were allergic to the radiation, according to their age. The finding revealed of patient female had higher concentrations than healthy females

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Section: Urinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alpha Tracks Examination for Female Urine Samples who are Suffering from Urinary Tract Infections

Mohammed¹,

Obaid

Abbas

et al. 2023

Baghdad Sci.J

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“…For decades, numerous studies have reported genetic damage produced by ionizing radiation ( Carante and Ballarini, 2020 ; Beheshti et al, 2021 ; Cornforth et al, 2021 ). Ionizing radiation can affect nucleic acids, proteins, and complex lipids either by direct deposition of energy into macromolecules or by generating reactive oxygen species (ROS) including hydrogen peroxide, superoxide anions, and other free radicals ( Azzam et al, 2012 ; Selim et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Ionizing radiation alters functional neurotransmission in Drosophila larvae

Zhang

Shen

et al. 2023

Front. Cell. Neurosci.

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IntroductionPatients undergoing cranial ionizing radiation therapy for brain malignancies are at increased risk of long-term neurocognitive decline, which is poorly understood and currently untreatable. Although the molecular pathogenesis has been intensively researched in many organisms, whether and how ionizing radiation alters functional neurotransmission remains unknown. This is the first study addressing physiological changes in neurotransmission after ionizing radiation exposure.MethodsTo elucidate the cellular mechanisms of radiation damage, using calcium imaging, we analyzed the effects of ionizing radiation on the neurotransmitter-evoked responses of prothoracicotropic hormone (PTTH)-releasing neurons in Drosophila larvae, which play essential roles in normal larval development.ResultsThe neurotransmitters dopamine and tyramine decreased intracellular calcium levels of PTTH neurons in a dose-dependent manner. In gamma irradiated third-instar larvae, a dose of 25 Gy increased the sensitivity of PTTH neurons to dopamine and tyramine, and delayed development, possibly in response to abnormal functional neurotransmission. This irradiation level did not affect the viability and arborization of PTTH neurons and successful survival to adulthood. Exposure to a 40-Gy dose of gamma irradiation decreased the neurotransmitter sensitivity, physiological viability and axo-dendritic length of PTTH neurons. These serious damages led to substantial developmental delays and a precipitous reduction in the percentage of larvae that survived to adulthood. Our results demonstrate that gamma irradiation alters neurotransmitter-evoked responses, indicating synapses are vulnerable targets of ionizing radiation.DiscussionThe current study provides new insights into ionizing radiation-induced disruption of physiological neurotransmitter signaling, which should be considered in preventive therapeutic interventions to reduce risks of neurological deficits after photon therapy.

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Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility

Spadella,

Silva,

Chies

et al. 2024

Antioxidants & Redox Signaling

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Radiation Damage in Biomolecules and Cells

Abstract: Ionizing radiation is widely used in medicine, both as a diagnostic tool and as a therapeutic agent [...]

Cited by 4 publications

References 31 publications

Alpha Tracks Examination for Female Urine Samples who are Suffering from Urinary Tract Infections

Alpha Tracks Examination for Female Urine Samples who are Suffering from Urinary Tract Infections

Ionizing radiation alters functional neurotransmission in Drosophila larvae

Insights Into Antioxidant Strategies to Counteract Radiation-Induced Male Infertility

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