Radiation Carcinogenesis in Dogs Irradiated During Prenatal and Postnatal Development

Benjamin, Stephen A.; Saunders, William J.; Angleton, George M.; Lee, Arthur C.

doi:10.1269/jrr.32.supplement2_86

Cited by 16 publications

(8 citation statements)

References 29 publications

(12 reference statements)

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“…Radiation carcinogenesis has been observed in dogs after therapeutic irradiation 1,18–21 and experimental studies 21–25 . A higher risk for development of a radiation‐induced osteosarcoma has been seen with high dose per fraction and higher total dose of radiation 21 .…”

Section: Discussionmentioning

confidence: 99%

Malignant Tumor Formation in Dogs Previously Irradiated for Acanthomatous Epulis

McEntee

Page

Théon

et al. 2004

Vet Radiology Ultrasound

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In this retrospective study of 57 dogs irradiated for oral acanthomatous epulis, 2 (3.5%) dogs developed a second tumor (sarcoma, osteosarcoma) in the radiation treatment field at 5.2 and 8.7 years after the end of radiation therapy. As opposed to previous reports, no second epithelial tumors developed in the radiation treatment field. There is a risk of radiation-induced carcinogenesis, but it appears that it is a relatively low risk and an event that occurs years after radiation therapy. Radiation-induced tumors are of more concern in younger dogs that undergo radiation therapy for tumors that are radioresponsive, such as acanthomatous epulis, where long-term survival is expected. The only statistically significant variable in the survival analysis was age, with dogs less than 8.3 years old having a significantly longer median overall survival (2322 days) than dogs older than 8.3 years (1106 days; P<0.0001).

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Section: Discussionmentioning

confidence: 99%

Malignant Tumor Formation in Dogs Previously Irradiated for Acanthomatous Epulis

McEntee

Page

Théon

et al. 2004

Vet Radiology Ultrasound

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“…Environmental factors also are likely to play a role in the etiology of HSA, although risk factors to which a realistic contribution could be attributed based on exposure and disease have not been identified in pet dogs. Exposure to high levels of ionizing radiation can promote development of HSA in experimental dogs [ 30 , 31 , 32 , 33 ]. Infectious etiologies have not been conclusively identified in this disease, although an association between HSA and Leishmaniasis was reported in three dogs in one study [ 34 ], and another reported a statistically increased frequency of Bartonella spp .…”

Section: Ontogeny Of Canine Hsamentioning

confidence: 99%

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives

Kim

Graef

Dickerson

et al. 2015

Veterinary Sciences

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Hemangiosarcoma (HSA) is an aggressive and common cancer in dogs. While cutaneous masses are often treatable by tumor excision, visceral tumors are almost always incurable. Treatment advances for this disease have been limited due to a poor understanding of the overall tumor biology. Based upon its histological appearance, HSA has been presumed to originate from transformed endothelial cells; however, accumulating data now suggest a pluripotent bone marrow progenitor as the cell of origin for this disease. More recently, the identification of a novel subclassification of HSAs has provided a foundation to further our understanding of the cellular characteristics of HSA tumor cells, along with those of the cells comprising the tumor microenvironment. These discoveries hold promise for the development of new approaches to improve treatments for canine HSA, as well as to establish the utility of this disease as a spontaneous model to understand the pathogenesis and develop new treatments for vascular tumors of humans. In this review, we will provide a brief historical perspective and pathobiology of canine HSA, along with a focus on the recent advances in the molecular and cellular understanding of these tumors. In addition, future directions that should continue to improve our understanding of HSA pathogenesis will be discussed.

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“…They found a tendency for increase in thyroid tumours and malignant lymphomas after irradiation during the perinatal period. Further studies by the same authors (Benjamin et al, 1991) showed a significant increase in benign and malignant neoplasms in young dogs, less than 4 years old, including fatal malignancies after irradiation at the late fetal (day 55 postconception) and neonatal (day 2 postpartum) periods. Lymphomas, haemangiosarcomas, and mammary carcinomas accounted for 51% of all tumours.…”

Section: Gestational Age and Cancer Riskmentioning

confidence: 88%

“…Inano et al (1996), using Wistar rats, reported that irradiation on day 20 postconception with doses less than 2.1 Gy did not induce any mammary tumours in the females, and even at 2.6 Gy, the incidence was very low. In contrast, Benjamin et al ( , 1991 reported a lifetime increase in fatal cancers in beagle dogs exposed to 0.16 or 0.83 Gy of gamma radiation during the perinatal period of day 55 postconception or 2 days postpartum. Schmahl (1988) concluded that the mouse system appears to be too insensitive for demonstrating whole body irradiation effects similar to those in dogs.…”

Section: Radiation Dose Response and Question Of Thresholdmentioning

confidence: 91%

“…(273) Benjamin et al (1991) reported that the risk of fatal malignancies after irradiation was greater in female than male beagle dogs exposed on day 55 post-conception. In a later paper, they observed a significant increase in the lifetime incidence of fatal lymphomas and haemangiosarcomas in female dogs, but not in males, after irradiation with 16 or 81 cGy of 60 Co gamma radiation at 55 days postconception (Benjamin et al, 1998).…”

Section: Sex Dependencementioning

confidence: 99%

See 1 more Smart Citation

Biological effects after prenatal irradiation (embryo and fetus)

Valentin¹

2003

Ann ICRP

120

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In its 1990 recommendations, the ICRP considered the radiation risks after exposure during prenatal development. This report is a critical review of new experimental animal data on biological effects and evaluations of human studies after prenatal radiation published since the 1990 recommendations.Thus, the report discusses the effects after radiation exposure during pre-implantation, organogenesis, and fetogenesis. The aetiology of long-term effects on brain development is discussed, as well as evidence from studies in man on the effects of in-utero radiation exposure on neurological and mental processes. Animal studies of carcinogenic risk from in-utero radiation and the epidemiology of childhood cancer are discussed, and the carcinogenic risk to man from in-utero radiation is assessed. Open questions and needs for future research are elaborated.The report reiterates that the mammalian embryo and fetus are highly radiosensitive. The nature and sensitivity of induced biological effects depend upon dose and developmental stage at irradiation. The various effects, as studied in experimental systems and in man, are discussed in detail. It is concluded that the findings in the report strengthen and supplement the 1990 recommendations of the ICRP.

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Radiation Carcinogenesis in Dogs Irradiated During Prenatal and Postnatal Development

Cited by 16 publications

References 29 publications

Malignant Tumor Formation in Dogs Previously Irradiated for Acanthomatous Epulis

Malignant Tumor Formation in Dogs Previously Irradiated for Acanthomatous Epulis

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives

Biological effects after prenatal irradiation (embryo and fetus)

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