Radiation-associated gliomas

Liwnicz, Boleslaw H.; Berger, Thomas S.; Liwnicz, Regina G.; Aron, Bernard S.

doi:10.1097/00006123-198509000-00008

Cited by 9 publications

(3 citation statements)

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“…Their onset peaks in the third and fourth decades and most have appeared before 43 years. Gliomas tend to occur much sooner after exposure, approximately 20% within 5 years of exposure and over 90% within 20 years [28,39,40,41,42, 44, 50]. The latency of a radiation-induced tumor impacts its effect on longevity and quality of life.…”

Section: Resultsmentioning

confidence: 99%

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Meta-Analysis of Cranial CT Scans in Children

Stein

Hurst²,

Sonnad

2008

Pediatr Neurosurg

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Objective: We aimed to estimate the risks of radiation exposure from a single head CT scan to children of different ages. Materials and Methods: We constructed a multistate time-dependent Markov model to simulate the course of children exposed to a head CT. The relevant literature was reviewed for probabilities, which were used to calculate tumor types, latencies after exposure and outcomes in the model. Where multiple approximations of the same probability had been reported, meta-analytic techniques were employed to compute pooled estimates. The model was then used to calculate the effect of the radiation exposure on life expectancy and quality of life for children following head CT at different ages. Results: The tumors likely to be induced by low-level cranial irradiation include thyroid carcinoma (47%), meningioma (34%) and glioma (19%). According to the model, a single head CT is likely to cause one of these tumors in 0.22% of 1-year-olds, 30% of whom will consequently die. The exposure will shorten the life expectancy of all exposed 1-year-olds by an average of 0.04 years and their expected quality of life by 0.02 quality-adjusted life years. The risks of radiation exposure diminish for older children. Conclusions: The model predicts that the effective radiation dose from a single head CT is capable of inducing a thyroid or brain tumor in an infant or child. These tumors can severely impact both quality of life and life expectancy. Care should be taken before ordering CT scans in children, particularly in infants and toddlers.

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Section: Resultsmentioning

confidence: 99%

“…Latencies were calculated from time of exposure for thyroid carcinomas [30, 35, 36], meningiomas [31, 37, 38] and cerebral gliomas [28,39,40,41,42,43,44]. Since we could not represent latency by a simple annual rate, we constructed a table for each tumor type, based on actual rates each year after exposure.…”

Section: Methodsmentioning

confidence: 99%

Meta-Analysis of Cranial CT Scans in Children

Stein

Hurst²,

Sonnad

2008

Pediatr Neurosurg

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“…Most of the radiation-associated intracranial neoplasms are sarcoma and meningioma. In the literature there are however anecdotal reports of occurrence of gliomas following ionizing radiation [10,11,12,13,14,15]. The occurrence of glioblastoma multiforme following prophylactic irradiation for ALL is uncommon considering the prevalence of ALL in the world population [16,17,18,19,20] (table 1).…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma Multiforme following Cranial Irradiation and Chemotherapy for Acute Lymphocytic Leukaemia

Menon

Muzumdar²,

Shah³

et al. 2007

Pediatr Neurosurg

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The most common secondary neoplasms which occur following cranial radiation therapy are sarcoma and meningioma. The occurrence of glioblastoma multiforme following radiation and chemotherapy in acute lymphocytic leukaemia (ALL) is rare. We report 3 cases of glioblastoma multiforme in children developing 11–72 months following completion of chemotherapy/radiotherapy for ALL. The exact cause for the development of glioblastoma multiforme following therapy for ALL is not clear. A genetic predisposition may be essential for the occurrence of such a highly malignant primary brain tumour in leukaemia patients, irrespective of radiation and/or chemotherapy. The pathogenesis and surgical management are discussed, and the literature on the subject is reviewed.

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