Radiation-associated changes in salivation of patients with cancer of maxillofacial region

Bykov, I. M.; Izhnina, E. V.; Кочурова, Е.В.; Лапина, Н. В.

doi:10.17116/stomat201897167-70

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…the surgery as well as the concurrent chemo-radiation therapy can irreversibly effect the salivary glands function and brosis of the surrounding tissues resulting in impaired oral functions and in uencing OHRQoL. (24,28) The current analyses, showed a greater proportion of males (75.9%) compared to females (24.1%) in the study similar to other studies (29,30), can be attributed to higher consumption of tobacco among males. (34) in addition, loss of the partner or absence of the partner had a higher negative impact on OHRQoL which agrees with other study result (35).…”

Section: Discussionsupporting

confidence: 83%

Assessment of Oral health related quality of life and its associated factors in head and neck cancer survivors, within one-year, post cancer treatment. A cross-sectional study

Farrukh,

Rozi,

Sawani

et al. 2023

Preprint

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Background Patients after completing their treatment for HNC, are often functionally challenged by the acute and chronic complications in the oral cavity such as oral pain, limited mouth opening, xerostomia etc. These complications are known to reduce their OHRQoL, because of restricted food intake, limited social activity and economic growth, therefore impacting their overall well-being and survival. This study aims to assess the OHRQoL and its associated sociodemographic factors, oral hygiene related factors and oral clinical parameters such as OH status and OM grade in HNC survivors within one-year post cancer treatment.Methodology This was a cross-sectional study performed among HNC survivors at the ENT and dental clinics of Aga Khan University Hospital, Karachi. OHRQoL was assessed using EORTC QLQ H&N – 35, patients were examined for oral hygiene status using OHI- simplified and oral mucositis grade using WHO oral mucositis scale at one point in time. One sample t- test and multiple linear regression was used to test OHRQoL and its associations with the sociodemographic and clinical factors.Results The results of the study showed an overall higher mean score for OHRQoL of 25.02 ± 15.86 (95% CI 21.46–28.57), with difficulty in mouth opening and dry mouth because of salivary dysfunction among the most affected domains with higher symptoms scores in the study population. Significant association of OHRQoL were found with BMI, OH status, marital status, monthly income, gender and fluoride toothpaste use in HNC patients within one-year post cancer treatment (p < 0.05).Conclusion: High mean score for OHRQoL in HNC patients suggests their QoL is negatively impacted by their poor oral health post cancer treatment, therefore it is important to evaluate and modify the current treatment modalities and involve multidisciplinary teams, to improve their OHRQoL thereby enhancing overall QoL.

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Section: Discussionsupporting

confidence: 83%

Assessment of Oral health related quality of life and its associated factors in head and neck cancer survivors, within one-year, post cancer treatment. A cross-sectional study

Farrukh,

Rozi,

Sawani

et al. 2023

Preprint

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“…When the total radiation dose exceeds 30Gy, signs of xerostomia are already considered irreversible. 20 , 21 Many patients with HNC who receive radiotherapy have long-term hyposalivation. 22 , 23 All participants in this study had radiation doses exceeding 30Gy, and irreversible damage to the salivary glands was predicted.…”

Section: Discussionmentioning

confidence: 99%

Effects of the professional oral care management program on patients with head and neck cancer after radiotherapy: A 12-month follow-up

Sohn

Park

Jung

et al. 2021

Journal of Dental Sciences

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Background/purpose Because oral health of patients with head & neck cancer is prone to disease after radiotherapy, effective and long-lasting oral care program is necessary. We aimed to evaluate the effects of the oral care management program, which lasted up to 12 months after radiotherapy for patients with head and neck cancer. Materials and methods Sixty-eight patients who visited a dental clinic prior to the initiation of radiotherapy were recruited and categorized into either a “healthy” or a “vulnerable” group. The vulnerable group was made of patients with dental caries or periodontal attachment loss. Professional oral hygiene care, including tooth brushing instructions, professional mechanical tooth cleaning, and fluoride varnish application, was conducted once every week for a month during radiotherapy and once every 3 months after radiotherapy. Oral health, including dental caries, plaques, gingival index, and periodontal attachment loss, was examined at baseline, 6 months, and 12 months after radiotherapy. Results ; Twenty-nine and 16 patients were followed up at 6 and 12 months after radiotherapy, respectively. Oral health indices, such as the number of decayed teeth, amount of plaque, and gingival index, did not significantly change in either group. However, the periodontal pocket depth significantly decreased in both groups at 6 months after baseline, and this decrease continued in the vulnerable group up to 12 months after baseline. Conclusion Periodic dental visits and professional oral hygiene care during and after radiotherapy were effective in maintaining oral health for over 12 months after radiotherapy in patients with head and neck cancer.

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“…Based on these data, cancer can be considered as a significant public health issue worldwide, and thus requires intense research into the improvement of prevention strategies and enhancing the effectiveness of treatment. Numerous types of curative therapy, including chemotherapy (4), gene therapy (5), radiotherapy and immunotherapy (6,7), are used to treat cancer. Radiotherapy is an effective and commonly employed treatment in the management of >50% of human malignancies and remains a standard therapeutic modality for cancer patients (8,9).…”

Section: Introductionmentioning

confidence: 99%

Effect of modulation of epithelial‑mesenchymal transition regulators Snail1 and Snail2 on cancer cell radiosensitivity by targeting of the cell cycle, cell apoptosis and cell migration/invasion (Review)

Assani

Zhou

2018

Oncol Lett

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Cancer is one of the leading causes of cancer-associated mortality worldwide. Several strategies of treatment, including radiotherapy, have been developed and used to treat this disease. However, post-treatment metastasis and resistance to treatment are two major causes for the limited effectiveness of radiotherapy in cancer patients. Epithelial-mesenchymal transition (EMT) is regulated by SNAIL family transcription factors, including Snail1 and Snail2 (Slug), and serves important roles in progression and cancer resistance to treatment. Snail1 and Slug also have been shown to be implicated in cancer treatment resistance. For resolving the resistance to treatment problems, combining the modulation of gene expression with radiotherapy is a novel strategy to treat patients with cancer. The present review focuses on the effect of Snail1 and Slug on cancer radiosensitivity by targeting cell apoptosis, the cell cycle and cell migration/invasion.

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Radiation-associated changes in salivation of patients with cancer of maxillofacial region

Cited by 9 publications

References 49 publications

Assessment of Oral health related quality of life and its associated factors in head and neck cancer survivors, within one-year, post cancer treatment. A cross-sectional study

Assessment of Oral health related quality of life and its associated factors in head and neck cancer survivors, within one-year, post cancer treatment. A cross-sectional study

Effects of the professional oral care management program on patients with head and neck cancer after radiotherapy: A 12-month follow-up

Effect of modulation of epithelial‑mesenchymal transition regulators Snail1 and Snail2 on cancer cell radiosensitivity by targeting of the cell cycle, cell apoptosis and cell migration/invasion (Review)

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