Radial shock wave therapy in dogs with hip osteoarthritis

Souza, Alexandre Navarro Alves de; Ferreira, Márcio Poletto; Hagen, Stéfano Carlo Filippo; Patricio, Geni Cristina Fonseca; Matera, Júlia Maria

doi:10.3415/vcot-15-01-0017

Cited by 18 publications

(13 citation statements)

References 46 publications

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“…Dynamic weight-bearing was assessed with a force platform, which provides an objective and sensitive measurement of limb loading during motion in dogs [ 60 , 61 ]. It is currently the reference standard for evaluating treatment outcome in dogs with various orthopedic and neurological conditions [ 62 – 64 ]. The determination of a symmetry index is a method to evaluate the balance in dynamic limb loading based on right to left comparisons rather than absolute values of the measured forces, which are subject to effects of absolute and relative dog velocity and acceleration [ 61 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial

et al. 2018

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ObjectiveTo investigate the clinical, cytological, and histopathological adverse effects of intra-articularly injected botulinum toxin A in dogs and to study whether the toxin spreads from the joint after the injection.MethodsA longitudinal, placebo-controlled, randomized clinical trial was conducted with six healthy laboratory Beagle dogs. Stifle joints were randomized to receive either 30 IU of onabotulinum toxin A or placebo in a 1:1 ratio. Adverse effects and spread of the toxin were examined by evaluating dynamic and static weight-bearing of the injected limbs, by assessing painless range of motion and pain on palpation of joints, and by performing synovial fluid analysis, neurological examination, and electrophysiological recordings at different examination time-points in a 12-week period after the injections. The dogs were then euthanized and autopsy and histopathological examination of joint structures and adjacent muscles and nerves were performed.ResultsIntra-articular botulinum toxin A did not cause local weakness or injection site pain. Instead, static weight-bearing and painless range of motion of stifle joints decreased in the placebo limbs. No clinically significant abnormalities associated with intra-articular botulinum toxin A were detected in the neurological examinations. Electrophysiological recordings showed low compound muscle action potentials in two dogs in the botulinum toxin A-injected limb. No significant changes were detected in the synovial fluid. Autopsy and histopathological examination of the joint and adjacent muscles and nerves did not reveal histopathological adverse effects of the toxin.ConclusionIntra-articular botulinum toxin A does not produce significant clinical, cytological, or histopathological adverse effects in healthy dogs. Based on the electrophysiological recordings, the toxin may spread from the joint, but its clinical impact seems to be low.

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Section: Discussionmentioning

confidence: 99%

Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial

et al. 2018

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“…The acoustic wave can be generated by kinetic energy as a result of a ballistic collision between two masses where the created energy can generate a shockwave that may be directed to biological tissue illicit a tissue treatment. The treatment capabilities of acoustic pressure pulses have been widely reported and is known to produce various responses in biological tissues, such as angiogenesis and anti-inflammatory effects [ 18 ], endorses the healing process in musculoskeletal diseases in humans [ 19 ], race horses [ 20 ] and dogs [ 21 ]. In humans, acoustic pressure pulses are also used to treat orthopedic inflammatory disorders [ 22 , 23 ], heart ischemia treatment [ 24 , 25 ] erectile dysfunction treatment [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…In Race horses, low power APT improved lameness disorders such as insertional desmopathies, tendinopathy, osteoarthritis myopathies, arthrosis and podotrochlosis syndrome [ 19 , 20 ]. In dogs, APT was used for shoulder lameness, degenerative joint disease (DJD of the hip, elbow, knee, wrist, and ankle), Legg Calve Perthes disease (degeneration of the head of the femur bone in the hind leg) osteoarthritis and spondylosis (degeneration of joints in the spine) [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of acoustic pulse therapy (APT), a non-antibiotic treatment for dairy cows with clinical and subclinical mastitis

Leitner¹,

Zilberman

Papirov

et al. 2018

PLoS ONE

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Clinical and subclinical mastitis affects 30% of cows and is regarded as the most significant economic burden on the dairy farm reducing milk yield and quality and increasing culling rate. A proprietary Acoustic Pulse Therapy (APT) device was developed specifically for treating dairy cows. The APT device was designed to produce deep penetrating acoustic pulses that are distributed over a large treated area at a therapeutic level. This paper presents findings from a clinical assessment of this technology for the treatment of dairy cows with subclinical and clinical mastitis. In subclinical mastitis, a group of 116 cows from 3 herds were identified with subclinical intramammary infection and enrolled in the study; 78 cows were assigned to the treatment group and 38 cows to the control group. Significant differences (P<0.001) were found where 70.5% of the cows in the treatment group returned to normal milk production, compared with only 18.4% of the control group. Daily milk yields of the treated cows increased significantly (P<0.05) and the percentage of cows with log somatic cell count under 5.6 cells/mL was significantly higher (P<0.001). Milk of the infected quarters appeared normal with lactose greater than 4.8%, but this difference was not significant. Of the treated cows with identified bacteria, 52.6% of the quarters were cured, while in the control group only 25.0% (P<0.001). Specifically, all cows identified with Escherichia coli in the treatment group were cured, with 66.6% cured with no intervention in the control. Spontaneous cure of glands infected with coagulase negative staphylococci (CNS) and Streptococci was low while treatment successfully increased the cure of CNS from 13.3% to 53.8% and that of Streptococci from 18.2% to 36.4%. Of the 4 cows identified with Staphylococcus aureus, 3 were cured. The clinical mastitis study group included 29 infected cows that were submitted either to a gold standard antibiotic treatment subgroup of 16 cows (n = 16) or to an APT treatment subgroup of 13 cows (n = 13). A cure of 18.7% was shown for the antibiotic treatment, of which logSCC returned to <5.6 cell/mL and 56.2% were culled. A cure of 76.9% was shown for the APT treatment with only one cow culled (7.7%).

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“…No involvement of the obturator nerve articular branches in the innervation of the HJC was determined in the dog by Kinzel et al [ 12 ]. However, Gasse et al [ 9 ], using acetylcholine esterase staining, detected contributions of obturator nerve branches to the innervation of the caudal part of the HJC in the dog. The latter observation was confirmed by recent studies [ 36 ] describing short articular nerve fibres arising from the obturator nerve and supplying the caudal aspect of the HJC.…”

Section: Discussionmentioning

confidence: 99%

“…For the patient, this means a significant improvement in the quality of life and more importantly, significant slowing of the atrophy of pelvic limb muscles [ 5 – 7 ]. Hip joint pain reduction can also be achieved using shockwave therapy [ 8 ; 9 ], caloric restriction [ 10 ; 11 ], physical activity control [ 12 ], physiotherapy [ 13 ; 14 ] non-steroidal anti-inflammatory and analgesic drugs [ 15 ], or surgically. But long-term drug therapy carries a risk of side effects in the gastrointestinal tract, liver and kidneys [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of lateral- versus medial-approach hip joint capsule denervation as surgical treatments of the hip joint pain; a neuronal tract tracing study in the sheep

et al. 2018

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ObjectiveTo evaluate efficacy of denervation of the of the hip joint capsule (HJC), as a treatment of hip joint pain. Specifically, we tested the hypothesis that HJC denervation will significantly reduce the number of sensory neurons innervating the capsule.Study designDenervation of the HJC from a medial or lateral approach was followed by retrograde tracing of sensory neurons innervating the capsule.AnimalsTwenty adult male sheep (30–40 kg of body weight; Polish merino breed) were used in the study.MethodsThe hip joint was denervated from medial (n = 5) or lateral (n = 5) surgical approaches. Immediately after denervation, the retrograde neural tract tracer Fast Blue (FB) was injected into the HJC. An additional ten animals (n = 5 for medial and n = 5 for lateral approach) received the same treatment without HJC denervation to provide the appropriate controls.ResultsResults of the study revealed that the vast majority of retrogradely labelled sensory neurons innervating the HJC originate from fifth lumbar to second sacral dorsal root ganglia. Both the medial and the lateral denervations significantly reduced the number of sensory neurons innervating the HJC (39.2% and 69.0% reduction respectively).ConclusionsThese results show that denervation of the HJC is an effective surgical procedure for reduction of the sensory neuronal input to the HJC. Moreover, the lateral approach was found to be significantly more effective for reducing sensory innervation as compared to the medial one.

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Radial shock wave therapy in dogs with hip osteoarthritis

Abstract: Outcomes of this study suggested beneficial effects of RSWT in dogs with hip osteoarthritis.

Cited by 18 publications

References 46 publications

Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial

Assessing adverse effects of intra-articular botulinum toxin A in healthy Beagle dogs: A placebo-controlled, blinded, randomized trial

Assessment of acoustic pulse therapy (APT), a non-antibiotic treatment for dairy cows with clinical and subclinical mastitis

Efficacy of lateral- versus medial-approach hip joint capsule denervation as surgical treatments of the hip joint pain; a neuronal tract tracing study in the sheep

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