Radial scar and carcinoma of the breast: microscopic findings in 32 cases

Mokbel, KM; Price, Ruth K.; Mostafa, A.; Williams, Nick; Wells, Clive; Perry, Nicholas; Carpenter, R

doi:10.1054/brst.1999.0081

Cited by 34 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, because no absolute mammographic criteria can be used to distinguish a RS or complex sclerosing lesion with associated benign epithelial proliferations from one containing carcinoma, 7,31-35 current practice supports performance of multiple stereotactic core needle biopsies 36,37 to fully evaluate lesions that are radiographically consistent with RS or complex sclerosing lesions. [2][3][4] Only in cases in which atypia is absent and there is good mammographic-pathologic correlation can an excisional biopsy be foregone. 37 If atypical hyperplasia or carcinoma in situ is present, then the treatment and prognostic implications of these particular lesions should apply.…”

Section: Discussionmentioning

confidence: 99%

“…However, with the widespread institution of mammographic screening programs, larger RS can be detected and may be virtually indistinguishable mammographically from small invasive carcinomas. [2][3][4] Histologically, RS are characterized by a region of central sclerosis surrounded by a variety of epithelial proliferative lesions, apocrine and cystic changes, and papillomas extending radially from a central zone of sclerosis. When such lesions are greater than 1.0 cm in size, they have been termed "complex sclerosing lesions."…”

mentioning

confidence: 99%

See 1 more Smart Citation

Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies

Sanders

Page

Simpson

et al. 2006

Cancer

104

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies

Sanders

Page

Simpson

et al. 2006

Cancer

104

View full text Add to dashboard Cite

show abstract

“…12,[15][16][17][18][19] The literature presents a confused picture with regard to the association of carcinoma with radial scar, with the incidence of associated breast carcinoma varying from 0% to 43%. 19,20,22,24,25,29,[31][32][33][34][35] The reported differences in the association of breast carcinoma with radial scars are difficult to reconcile. Many studies are limited by small numbers, the retrospective nature of the analysis, and sometimes by a selection bias of patients likely to be at risk of malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…30 Some studies reviewing radial scars have reported a high rate of association with DCIS and invasive carcinoma (up to 43% in one series). 18,19,29,30,33,34 These series derived patients from selected sources, such as a surgical service of a cancer hospital and other tertiary referral centers, where patients are more likely to be at risk of breast carcinoma. They were mostly case series, and not population-based studies.…”

Section: Discussionmentioning

confidence: 99%

Fourteen‐gauge needle core biopsy of mammographically evident radial scars

Cawson¹,

Malara²,

Kavanagh³

et al. 2003

Cancer

View full text Add to dashboard Cite

The effect of pH on the precipitation of soy protein between pH 4 and 6.8 was investigated. Precipitation between pH 5.7 and 6.8 gave a binary liquid‐liquid separation in which a protein‐rich secondary liquid phase containing between 20 – 30 wt % protein of 80 – 99% purity in glycinin formed as droplets of 1 – 10 μm. The droplets could be coalesced upon centrifugation to form a homogeneous bottom liquid layer. The high‐protein concentration phase was stable (did not precipitate or crystallize) for up to several months when stored at 4°C. Stable high‐protein liquid phases have not previously been reported. In the pH region for which liquid‐liquid separation occurred (pH 6.15 to 5.35), the droplet‐size distribution was controlled by nucleation and growth. No drop breakage, and little or no drop coalescence was observed. Mixer speed and geometry did not have a large effect on the size of the protein‐rich droplets in suspension. Nucleation occurred in two separate bursts at pH 6.15 and pH 5.85, followed by growth of the new nuclei as pH was decreased. Thus, the drop‐size distribution was monomodal between 6.15 and 5.85, and bimodal between pH 5.85 and 5.35. At pH 5.6 and below, protein precipitated as amorphous material which intertwined with and bound primary particles into aggregates. These agglomerates grew with decreasing pH, particularly below pH 5.35, as more protein precipitated with amorphous material acting as a binder. The addition of NaCl prevented the liquid‐liquid separation at higher pH. Instead solid precipitates of a different morphology were formed at low‐pH only. © 2007 American Institute of Chemical Engineers AIChE J 2007

show abstract

“…Pour d'autres au contraire détermi-ner le caractère indépendant de ce risque est diffi cile dans la mesure où les lésions atypiques associées sont fréquentes. Rarement diagnostiquée sur MB, l'ensemble des auteurs confi rment, compte tenu du risque de cancer associé, la nécessité d'une exérèse chirurgicale [40,47,67,69,94,95,108]. Il est par conséquent important de réaliser que les papillomes multiples présentent des atypies fréquen-tes et qu'en ce sens ces papillomes réalisent un risque très important.…”

Section: Guidelinesunclassified