Radial Extracorporeal Shock Wave Therapy (rESWT) Induces New Bone Formation in vivo: Results of an Animal Study in Rabbits

Inhibitory Effect of Low‐Intensity Pulsed Ultrasound on the Expression of Lipopolysaccharide‐Induced Inflammatory Factors in U937 Cells

“…It has been demonstrated that low‐intensity pulsed US promotes cell proliferation, up‐regulates the differentiation of cementoblasts, and increases extracellular matrix synthesis in fibroblasts and myoblasts . Previous trials have confirmed that low‐intensity pulsed US accelerates bone fracture repair and bone regeneration . Our recent studies have also demonstrated that low‐intensity pulsed US promotes alveolar bone and periodontal fenestration defect healing .…”

Pulsed Focused Ultrasound Treatment of Muscle Mitigates Paralysis-Induced Bone Loss in the Adjacent Bone: A Study in a Mouse Model

“…Tissue heating resulting from ultrasound absorption is known to decrease the nerve conduction velocity reversibly or, above a certain level of heating, irreversibly (Tsui et al 2005). Ultrasound-induced cavitation is another form of mechanical impact on tissue that is believed to stimulate tissue regeneration in other applications such as bone nonunion healing and wound healing (Elster et al 2010; Gollwitzer et al 2013; Kuo et al 2009). To induce cavitation activity in tissue, the peak rarefactional pressure has to exceed cavitation threshold, which, although still controversial, is believed to be 6.5 MPa (Hwang et al 2006).…”

“…Ultrasound has also been used in animal models in an attempt to mitigate bone loss induced by spinal cord injury, ovariectomy and neurectomy, yet the results remain controversial (Carvalho and Cliquet Junior 2004; Cook et al 2001; Ferreri et al 2011; Gollwitzer et al 2013; van der Jagt et al 2013; Warden et al 2001a; Yang et al 2005). In particular, Ferreri et al (2011) applied LIPUS to the L4 and L5 vertebrae in ovariectomized rats for 20 min daily, 5 d a wk, for 4 wk, and observed partial mitigation of trabecular bone loss compared with the control group.…”

Efectividad de las ondas de choque radiales para el tratamiento de pseudoartrosis de astrágalo

“…reducción de la relación RANKL/OPG 16,17 . Aunque la pseudoartrosis es un problema desafiante para los ortopedistas, Zelle et al 18 mencionan en sus estudios que datos experimentales con ondas de choque estimulan la formación ósea in vitro y en vivo, de manera que se pueden obtener resultados exitosos; y estudios recientes, en 2013, demuestran los mismos resultados con el uso de ondas radiales en la formación de nuevo hueso 19 y el efecto osteogénico en humanos. 20 Finalmente, se puede concluir que, aunque hacen falta estudios, las ondas de choque radiales han demostrado la efectividad en el tratamiento de la pseudoartrosis, con recuperación anatómica y funcional, fundamentada en el proceso de mecano-transducción, de manera tal que los estímulos mecánicos generados por las ondas de choque extracorpóreas se traducen en efectos biológicos y cambios bioquímicos a este nivel.…”