Radar Chart Deviation Analysis of Prion Protein Amino Acid Composition Defines Characteristic Structural Abnormalities of the N-Terminal Octapeptide Tandem Repeat

Yokotani, Satoru; Nose, Takeru; Horiuchi, Yuji; Matsushima, Ayami; Shimohigashi, Yasuyuki

doi:10.2174/092986608785849182

Cited by 1 publication

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“…The resulting patterns exhibit characteristics of the data, which can be recognized by preattentive perception. 16 These data visualization methods have been used in many other fields including information visualization, 16,17 computer science, 18,19 biology, 20 education, 21 and health care. 22,23 In this work,…”

Section: -10mentioning

confidence: 99%

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Improved data visualization techniques for analyzing macromolecule structural changes

et al. 2012

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The empirical phase diagram (EPD) is a colored representation of overall structural integrity and conformational stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method suffers from a number of deficiencies including lack of a meaningful relationship between color and actual molecular features, difficulties in identifying contributions from individual techniques, and a limited ability to be interpreted by color-blind individuals. In this work, three improved data visualization approaches are proposed as techniques complementary to the EPD. The secondary, tertiary, and quaternary structural changes of multiple proteins as a function of environmental stress were first measured using circular dichroism, intrinsic fluorescence spectroscopy, and static light scattering, respectively. Data sets were then visualized as (1) RGB colors using three-index EPDs, (2) equiangular polygons using radar charts, and (3) human facial features using Chernoff face diagrams. Data as a function of temperature and pH for bovine serum albumin, aldolase, and chymotrypsin as well as candidate protein vaccine antigens including a serine threonine kinase protein (SP1732) and surface antigen A (SP1650) from S. pneumoniae and hemagglutinin from an H1N1 influenza virus are used to illustrate the advantages and disadvantages of each type of data visualization technique.

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Section: -10mentioning

confidence: 99%

“…12,[17][18][19][20][21][22][23] It has many similar forms and names such as star glyph, star chart, and spider chart. The major idea for this data visualization approach is to arrange multiple axes in evenly spaced angles from the same starting point to form a polar coordinate system.…”

Section: Construction Of Radar (Star) Diagramsmentioning

confidence: 99%