RAD51 restricts DNA over-replication from re-activated origins
Sergio Muñoz,
Elena Blanco-Romero,
Daniel González-Acosta
et al.
Abstract:Eukaryotic cells rely on several mechanisms to ensure that the genome is duplicated precisely once in each cell division cycle, preventing DNA over-replication and genomic instability. Most of these mechanisms limit the activity of origin licensing proteins to prevent the reactivation of origins that have already been used. Here, we have investigated whether additional controls restrict the extension of re-replicated DNA in the event of origin re-activation. In a genetic screening in cells forced to re-activat… Show more
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