Abstract:Oxygen and various types of peroxides generated in the process of cell metabolism are important sources of DNA damage. Peroxides can interact with different DNA groups, which may ultimately result in damage to bases and apurine/apyrimidine (AP) sites or the breaks of DNA strands [1]. In addition to direct DNA oxidation, bases damaged by peroxides can be incor porated into this molecule as a result of replication synthesis. An example of this process is the incorpora tion of 8 hydroxyguanine (8 oxoG) in DNA whi… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.