“…TAAR1 has a wide agonist spectrum that includes endogenous amines - both the common biogenic amines (DA; norepinephrine, NE and serotonin, 5HT) and trace amines (e.g., PEA, tyramine, octopamine, synephrine and tryptamine) as well as structurally-related AMPH-like compounds (AMPH, METH and MDMA; Bunzow et al, 2001; ractopamine, Liu et al, 2014), and thyronamines (Scanlan et al, 2004; Hart et al, 2006; Wainscott et al, 2007; Xie et al, 2007b). The receptor’s wide-spread expression in many different types of neurons (Borowsky et al, 2001; Bunzow et al, 2001; Lindemann et al, 2008; Espinoza et al, 2015), astrocytes (Cisneros and Ghorpade, 2014), immune cells (D’Andrea et al, 2003; Nelson et al, 2007; Wasik et al, 2012; Panas et al, 2012; Sriram et al, 2015) and cells of the cardiovascular system (Scanlan et al, 2004; Frascarelli et al, 2008; Broadley et al, 2009) suggests TAAR1-mediated signaling subserves one or more fundamental roles in cellular physiology (Grandy, 2007; Xie et al, 2007b; Lindemann et al, 2008).…”