Racial Variation in Prostate Cancer Upgrading and Upstaging Among Men with Low-risk Clinical Characteristics

Jalloh, Mohamed; Myers, Frank; Cowan, Janet E.; Carroll, Peter R.; Cooperberg, Matthew R.

doi:10.1016/j.eururo.2014.03.026

Cited by 82 publications

(68 citation statements)

References 28 publications

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“…Long-term oncologic outcomes for combined ADT in stage IV PCa [32] Prospective patient registries CaPSURE: UCSF Cancer of the Prostate Strategic Urologic Research Endeavor Development and validation of the CAPRA score to predict pathologic and biochemical outcomes after RP [129] Time trends and variation in primary treatment of PCa in the USA [130] Long-term health-related quality-of-life outcomes after PCa treatment [95] Comparative effectiveness of RP, radiotherapy, and ADT in patients with clinically localized PCa [89] Impact of ADT on physical, mental, and emotional wellbeing in PCa patients [131] Association between race and the likelihood of upgrading, upstaging, and positive surgical margins at RP [132] Cost burden of PCa according to treatment type [106] MUSIC: Michigan Urological Survey Improvement Collaborative…”

Section: Caesar: Comparative Effectivenessmentioning

confidence: 99%

Prostate Cancer Registries: Current Status and Future Directions

Gandaglia¹,

Bray

Cooperberg

et al. 2016

European Urology

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Context: Disease-specific registries that enroll a considerable number of patients play a major role in prostate cancer (PCa) research. Objective: To evaluate available registries, describe their strengths and limitations, and discuss the potential future role of PCa registries in outcomes research. Evidence acquisition: We performed a literature review of the Medline, Embase, and Web of Science databases. The search strategy included the terms prostate cancer, outcomes, statistical approaches, population-based cohorts, registries of outcomes, and epidemiological studies, alone or in combination. We limited our search to studies published between January 2005 and January 2015. Evidence synthesis: Several population-based and prospective disease-specific registries are currently available for prostate cancer. Studies performed using these data sources provide important information on incidence and mortality, disease characteristics at presentation, risk factors, trends in utilization of health care services, disparities in access to treatment, quality of care, long-term oncologic and health-related quality of life outcomes, and costs associated with management of the disease. Although data from these registries have some limitations, statistical methods are available that can address certain biases and increase the internal and external validity of such analyses. In the future, improvements in data quality, collection of tissue samples, and the availability of data feedback to health care providers will increase the relevance of studies built on population-based and disease-specific registries. Conclusions: The strengths and limitations of PCa registries should be carefully considered when planning studies using these databases. Although randomized controlled trials still provide the highest level of evidence, large registries play an important and growing role in advancing PCa research and care. Patient summary: Several population-based and prospective disease-specific registries for prostate cancer are currently available. Analyses of data from these registries yield information that is clinically relevant for the management of patients with prostate cancer.

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Section: Caesar: Comparative Effectivenessmentioning

confidence: 99%

Prostate Cancer Registries: Current Status and Future Directions

Gandaglia¹,

Bray

Cooperberg

et al. 2016

European Urology

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“…PSA density, obesity and prostate size were clinical predictors of Gleason upgrading. Family history, smoking status and clinical stage were not found to predict upgrade, while Jalloh et al [12] has further noted that although African American men carry a higher burden of prostate cancer, they did not note any statistically significant difference in rates of upgrading between racial groups, indicating that race is not a predictive factor.…”

Section: Discussionmentioning

confidence: 91%

What Are the Predictive Factors for Gleason Score Upgrade following RP?

Alchin

Murphy²,

Lawrentschuk

2015

Urol Int

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The Gleason score is one of a number of factors used in staging patients diagnosed with prostate cancer and in determining the treatment path such patients will ultimately follow. However, discrepancies in the Gleason scores obtained through biopsy compared with the final pathological staging of specimens following radical prostatectomy are not uncommon. Incorrect Gleason scoring can potentially influence treatment decisions and therefore, it is imperative that research is undertaken to elucidate factors that may be able to predict whether a patient's Gleason score might need to be reconsidered. A literature review was undertaken in late 2014 to highlight some of these factors that require further investigation.

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“…Bunlardan en önemlileri PSA, RRP GS, T evresi ve cerrahi sınır pozitifliğidir (12). Prostat volümünün prostat kanseri derece yükselmesinde etkili faktörlerden olduğunu gösteren çalışmalar mevcuttur (14). Radikal prostatektomi materyalindeki tümör hacmi de kanser hücre diferansiyasyonu, tümör nekrozu ve vaskülerizasyonu gibi tümörün biyolojik özelliklerini yansıtan diğer bir tümör ilişkili faktördür (15,16).…”

Section: Discussionunclassified

Relationship Between Tumor Density in Radical Prostatectomy Material, Preoperative Predictive Factors and Biochemical Recurrence

Çelik¹,

Bozkurt²,

Aslan³

et al. 2017

uob

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Objective: In this study, we assessed the relationship between tumor density (tumor volume prostate volume ratio), preoperative predictive factors and biochemical recurrence (BR) in patients who underwent radical retropubic prostatectomy (RRP) for prostate cancer in our clinic. Materials and Methods: For the patients undergoing RRP between 2005-2015 preoperative predictive factors, postoperative prognostic factors and BR status were evaluated. Preoperative and postoperative factors were compared between the patient groups whose BR was detected as positive and negative. Subsequently, the cut-off value effecting BR of tumor density was determined and the preoperative predictive values, postoperative prognostic factors and BR rates were investigated in patients whose tumor density found low and high. Results: BR was detected in 63 of 338 patients who underwent RRP, but not in 275 patients. In BR positive patients of multivariate analysis, the prostate needle biopsy (PNB) Gleason score of preoperative predictive factors, number of focus and perineural invasion presence and only surgical margin positivity were detected to be significantly higher from the postoperative prognostic factors (p<0.001). The cut-off value of tumor density affecting BR positivity was detected as 4.34 cc/cc (AUC: 0.711, p<0.001). BR was 4.65 times higher in patients with tumor density >4.34 cc/cc compared to patients with tumor density ≤4.34 cc/cc (p<0.001, odds ratio: 4.65). Sensitivity and specifity of the tumor density of 4.34 cc/cc value for BR were detected as 68.3% and 68.4%, separately. Moreover, it was observed in multivariate analysis that prostate specific antigen (PSA) density of preoperative data, PNB tumor percentage and number of focus were solely associated with high tumor density (>4.34 cc/cc). Conclusion: In conclusion, it was found that the most important prognostic factors affecting BR were surgical margin positivity and high tumor density; PSA density, PNB tumor percentage and number of focus were alone associated with high tumor density among the preoperative predictive factors and all predictive factors were positively correlated with tumor density. Keywords: Prostate cancer, radical retropubic prostatectomy, tumor volume, tumor density, biochemical recurrence Amaç: Bu yazıda kliniğimizde prostat adenokarsinomu nedenli radikal retropubik prostatektomi (RRP) yapılan hastaların prostatektomi materyalindeki tümör dansitesinin (tümör hacminin prostat volümüne oranı) preoperatif prediktif faktörler ve biyokimyasal rekürrens (BR) ile ilişkisi araştırıldı. Gereç ve Yöntem: 2005-2015 tarihleri arasında RRP yapılan hastaların preoperatif prediktif faktörleri, postoperatif prognostik faktörleri ve BR durumları değerlendirildi. BR pozitif ve negatif saptanan hasta gruplarında preoperatif ve postoperatif faktörler karşılaştırıldı. Sonrasında tümör dansitesinin BR üzerine etkili cut-off değeri saptanarak tümör dansitesi düşük ve yüksek saptanan hastalar arasındaki preoperatif prediktif veriler, postoperatif prognostik faktörler ve BR...

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Racial Variation in Prostate Cancer Upgrading and Upstaging Among Men with Low-risk Clinical Characteristics

Cited by 82 publications

References 28 publications

Prostate Cancer Registries: Current Status and Future Directions

Prostate Cancer Registries: Current Status and Future Directions

What Are the Predictive Factors for Gleason Score Upgrade following RP?

Relationship Between Tumor Density in Radical Prostatectomy Material, Preoperative Predictive Factors and Biochemical Recurrence

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