Establishing psychological safety by increasing control and connectedness is often the first step in addressing traumatic distress in trauma therapy. Qualitative research suggests cultural differences between providers and clients may pose unique challenges to this process. The aim of this meta-ethnography was to understand how safety is negotiated within the therapeutic alliance in inter-cultural trauma therapy. Five databases were searched (MEDLINE, CINAHL, EMBASE, PsycINFO, and ASSIA) using a pre-planned search strategy in June 2021; this was further updated in June 2022. Sixteen studies were included in the review. The synthesis highlighted that safety is negotiated in a web of relationships that go beyond just the therapeutic dyad. Personal connection, non-verbal communication, tolerating discomfort, and sharing the role of an educator with the client were some of the strategies used by therapists to bridge cultural differences. These strategies created various cultural and role conflicts, which were managed by addressing stigma, clarifying roles (including interpreters’), and creating a work-life balance. Structural factors such as organisational protocols, lack of institutional support, cultural stigma, and the asylum-seeking process hindered the negotiation of safety. Based on this meta-ethnography, a framework was developed to help mental health professionals negotiate safety in inter-cultural trauma therapy.