Racial Frequencies in Congenital Heart Disease

Maron, Barry J.; Applefeld, Judith M.; Krovetz, L. Jerome

doi:10.1161/01.cir.47.2.359

Cited by 11 publications

(9 citation statements)

References 6 publications

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“…Studies also reported Black-White differences in prevalence for infants with left obstructive CHDs. NH-Black infants are reported to have lower prevalence of hypoplastic left heart syndrome [19,20], aortic valve atresia/stenosis [1,3,8,18] and coarctation of the aorta [3,8,17,[21][22][23] relative to NH-Whites. In our study we only observed a statistically significant lower prevalence for NH-Black infants with aortic valve atresia/stenosis.…”

Section: Discussionmentioning

confidence: 99%

Is the Prevalence of Specific Types of Congenital Heart Defects Different for Non-Hispanic White, Non-Hispanic Black and Hispanic Infants?

Nembhard

Salemi

Wang

et al. 2009

Matern Child Health J

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Background Our purpose was to determine the prevalence of specific types of CHD among non-Hispanic (NH)-Black, NH-White, and Hispanic infants. Methods We conducted a retrospective cohort study with 9,352 singleton infants diagnosed with conotruncal, right or left obstructive or septal CHDs from the Florida Birth Defects Registry, born 1998-2003 to resident NH-White, NH-Black, and Hispanic women aged 15-49. Defect-specific prevalence rates, prevalence ratios and P-values were calculated for each type of CHD and by number of defects for each racial/ ethnic group. Results Compared to NH-Whites, NH-Blacks had higher rates of pulmonary valve atresia/stenosis but lower frequency of aortic valve atresia/stenosis and ventricular septal defect. Hispanics had lower rates of aortic valve atresia/stenosis and atrioventricular septal defects than NH-Whites. Conclusions Although few racial/ethnic differences in prevalence are present among infants with major CHD, observed differences are clinically meaningful. However, the underlying etiologies for the observed differences remain unknown.

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Section: Discussionmentioning

confidence: 99%

Is the Prevalence of Specific Types of Congenital Heart Defects Different for Non-Hispanic White, Non-Hispanic Black and Hispanic Infants?

Nembhard

Salemi

Wang

et al. 2009

Matern Child Health J

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“…Compared with black infants, white infants have been found to have an increased prevalence of Ebstein's anomaly, aortic stenosis, atrioventricular septal defects, ASDs, 192 coarctation of the aorta, 36,192,193 truncus arteriosus, transposition of the great arteries, tetralogy of Fallot, 36,192 PDA,192,194 pulmonary stenosis, 192,194 hypoplastic left heart syndrome, 194,195 and a decreased prevalence of pulmonary stenosis. 194 In a population-based study of variations in prevalence of birth defects in offspring of Hispanic and black women in California between 1987 and 1997, no variations in prevalence were noted compared with the prevalence in offspring of non-Hispanic white women.…”

Section: Race/ethnicitymentioning

confidence: 99%

Noninherited Risk Factors and Congenital Cardiovascular Defects: Current Knowledge

Jenkins¹,

Correa²,

Feinstein³

et al. 2007

Circulation

700

336

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Abstract-Prevention of congenital cardiovascular defects has been hampered by a lack of information about modifiable risk factors for abnormalities in cardiac development. Over the past decade, there have been major breakthroughs in the understanding of inherited causes of congenital heart disease, including the identification of specific genetic abnormalities for some types of malformations. Although relatively less information has been available on noninherited modifiable factors that may have an adverse effect on the fetal heart, there is a growing body of epidemiological literature on this topic. This statement summarizes the currently available literature on potential fetal exposures that might alter risk for cardiovascular defects. Information is summarized for periconceptional multivitamin or folic acid intake, which may reduce the risk of cardiac disease in the fetus, and for additional types of potential exposures that may increase the risk, including maternal illnesses, maternal therapeutic and nontherapeutic drug exposures, environmental exposures, and paternal exposures. Information is highlighted regarding definitive risk factors such as maternal rubella; phenylketonuria; pregestational diabetes; exposure to thalidomide, vitamin A cogeners, or retinoids; and indomethacin tocolysis. Caveats regarding interpretation of possible exposure-outcome relationships from case-control studies are given because this type of study has provided most of the available information. Guidelines for prospective parents that could reduce the likelihood that their child will have a major cardiac malformation are given. Issues related to pregnancy monitoring are discussed. Knowledge gaps and future sources of new information on risk factors are described.

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“…There are several reports which suggest that the incidence and particularly the pattern of congenital heart disease (CHD) may vary in different geographical locations [1][2][3][4][5][6]; but the extent to which such reported variations are attributable to differences in genetic predisposition, environmental factors, or in study methodology and diagnostic precision remains uncertain [7][8][9][10][11][12][13]. There is, therefore, a continuing need for studies on various aspects of CHD in different communities and races.…”

mentioning

confidence: 99%