Racial Factors and The Risk of Chronic Pancreatitis

Lowenfels, Albert B.; Madelenat, P.; Grover, Hemal; Gerber, Eric; Korsten, Mark A.; Antunes, Maria Teresa; Marques, A.P.; Pitchumoni, C. S.

doi:10.1111/j.1572-0241.1999.00952.x

Cited by 50 publications

(16 citation statements)

References 18 publications

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“…115 The incidence of alcoholinduced pancreatitis varies considerably, ranging from 38% to 94%, among different cohorts of patients in industrialized countries, 3,[42][43][44]47,116,117 and differences in racial susceptibility may exist between patients of African origin and Caucasians. 118 Patients with chronic pancreatitis have been categorized so far into clusters of patients with alcoholic, nonalcoholic or idiopathic, and hereditary pancreatitis. With increasing knowledge of the genetic background, these clusters no longer refl ect the complexity and possible interactions of the different risk factors.…”

Section: Discussionmentioning

confidence: 99%

The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease

2007

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The M-ANNHEIM multiple risk factor classification system is simple, objective, accurate, and relatively noninvasive, and it incorporates etiology, different stages of the disease, and various degrees of clinical severity. This new classification system will be helpful for investigating the impact and interaction of various risk factors on the course of the disease and will facilitate the comparison and combination of interinstitutional data.

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Section: Discussionmentioning

confidence: 99%

The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease

2007

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“…Thus, overrepresentation of males among patients with alcoholic pancreatitis reflects a higher prevalence of alcohol consumption than sex-based differences in susceptibility. Compared with whites, the rates of alcoholic pancreatitis are two-to threefold higher among blacks [20]. This observation, initially reported by Lowenfels et al [20], has been confirmed by several investigators [21, 22•, 23].…”

Section: Alcohol As An Etiology For Pancreatitismentioning

confidence: 54%

“…Compared with whites, the rates of alcoholic pancreatitis are two-to threefold higher among blacks [20]. This observation, initially reported by Lowenfels et al [20], has been confirmed by several investigators [21, 22•, 23]. However, the reasons for racial differences in susceptibility to pancreatitis are unclear and need further study.…”

Section: Alcohol As An Etiology For Pancreatitismentioning

confidence: 56%

Recent Advances in the Epidemiology of Alcoholic Pancreatitis

Yadav

2011

Curr Gastroenterol Rep

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Clinical observation has defined the medical profile of alcoholic pancreatitis, but its low incidence and prevalence has limited characterizing the disease at a population level, the contribution of environmental exposures, and a clear picture of its natural history. Recent studies have defined the impact of alcohol use and smoking on disease risk, and a threshold for alcohol consumption has been identified. Recurrent attacks of acute pancreatitis have been linked with continued alcohol consumption, and aggressive alcohol intervention has been shown to decrease recurrence. Progression from alcoholic acute pancreatitis to chronic pancreatitis is now believed to occur infrequently, and factors associated with progression have been identified. Alcoholic pancreatitis reduces lifespan in these patients, and the economic impact of pancreatitis is substantial. Efforts are needed to increase awareness of the impact of alcohol consumption and smoking on risk for pancreatitis and the benefits of cessation for primary and secondary prevention.

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“…For alcoholic pancreatitis, evidence suggests that, compared with white populations, US blacks and other black populations who drink heavily are more prone to develop pancreatitis than to develop liver cirrhosis [8].…”

Section: Racial Factorsmentioning

confidence: 99%

The epidemiology and impact of pancreatic diseases in the United States

Lowenfels

Sullivan

Fiorianti

et al. 2005

Curr Gastroenterol Rep

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In the United States, acute pancreatitis, chronic pancreatitis, and pancreatic cancer are the most common pancreatic disorders requiring diagnosis and treatment. Pancreatic cancer is responsible for nearly 30,000 annual deaths and is the second most common cause of death from any type of gastrointestinal disease. Gallstone disease, which is strongly associated with obesity, and excessive consumption of alcohol are the major risk factors for benign pancreatic disease, whereas smoking is the most important factor known to cause pancreatic cancer. Therefore, to reduce the overall burden of pancreatic disease, we should focus on the control of three lifestyle factors: smoking, drinking, and obesity.

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Racial Factors and The Risk of Chronic Pancreatitis

Cited by 50 publications

References 18 publications

The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease

The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease

Recent Advances in the Epidemiology of Alcoholic Pancreatitis

The epidemiology and impact of pancreatic diseases in the United States

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