Background: The clinical clerkship is a crucial stage in nursing training and dissatisfaction at this stage may cause a nurse quit in future. This study aimed to evaluate the relationship among personality dimensions, spirituality, coping strategies and clinical clerkship satisfaction in intern nursing students. Methods: This was a correlational, cross-sectional study. A total of 293 participants were selected using cluster random sampling. All participants were provided with standard questionnaires including personality dimensions (NEO_FFI), spirituality, coping strategies (WoCQ), and satisfaction with clinical clerkship. Data analyzed using Pearson correlation and hierarchical multiple regression.Results: The results showed that spirituality, problem-focused coping and extraversion (of personality dimensions) played a significant role in predicting clinical clerkship satisfaction among intern nursing students (p<.01). Regression analysis showed openness, extraversion, and spirituality could significantly predict problem-focused coping style in intern nursing students (p<.05). However, personality dimensions and spirituality were not good predictors for emotion-focused coping among intern nursing students.Conclusion: Personality dimensions, coping strategies and, in particular, spirituality are good predictors of clinical clerkship satisfaction among intern nursing students.