Racial/ethnic differences in the prognostic utility of left ventricular mass index for incident cardiovascular disease

Akintoye, Emmanuel; Mahmoud, Karim; Shokr, Mohamed; Sandio, Aubin; Mallikethi-Reddy, Sagar; Sheikh, Muhammad Adil; Adegbala, Oluwole; Egbe, Alexander C.; Briasoulis, Αlexandros; Afonso, Luís

doi:10.1002/clc.22914

Cited by 10 publications

(15 citation statements)

References 39 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…report greater prognostic utility of LVMi for predicting cardiovascular events for Chinese and Hispanic populations in comparison to non-Hispanic Whites. 38 Similarly, there are reports of significant ethnic differences in ventricular remodelling in response to important cardiovascular risk factors such as hypertension. 36 As ethnic variation exist for LV parameters, it is possible that there are also ethnic differences in the morphology of other cardiac chambers (right ventricle, atria).…”

Section: Discussionmentioning

confidence: 99%

Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis

Raisi‐Estabragh

Kenawy

Aung

et al. 2020

European Heart Journal - Cardiovascular Imaging

View full text Add to dashboard Cite

Aims To determine population-related and technical sources of variation in cardiac magnetic resonance (CMR) reference ranges for left ventricular (LV) quantification through a formal systematic review and meta-analysis. Methods and results This study is registered with the International Prospective Register of Systematic Reviews (CRD42019147161). Relevant studies were identified through electronic searches and assessed by two independent reviewers based on predefined criteria. Fifteen studies comprising 2132 women and 1890 men aged 20–91 years are included in the analysis. Pooled LV reference ranges calculated using random effects meta-analysis with inverse variance weighting revealed significant differences by age, sex, and ethnicity. Men had larger LV volumes and higher LV mass than women [LV end-diastolic volume (mean difference = 6.1 mL/m2, P-value = 0.014), LV end-systolic volume (MD = 4 mL/m2, P-value = 0.033), LV mass (mean difference = 12 g/m2, P-value = 7.8 × 10−9)]. Younger individuals had larger LV end-diastolic volumes than older ages (20–40 years vs. ≥65 years: women MD = 14.0 mL/m2, men MD = 14.7 mL/m2). East Asians (Chinese, Korean, Singaporean-Chinese, n = 514) had lower LV mass than Caucasians (women: MD = 6.4 g/m2, P-value = 0.016; men: MD = 9.8 g/m2, P-value = 6.7 × 10−5). Between-study heterogeneity was high for all LV parameters despite stratification by population-related factors. Sensitivity analyses identified differences in contouring methodology, magnet strength, and post-processing software as potential sources of heterogeneity. Conclusion There is significant variation between CMR normal reference ranges due to multiple population-related and technical factors. Whilst there is need for population-stratified reference ranges, limited sample sizes and technical heterogeneity precludes derivation of meaningful unified ranges from existing reports. Wider representation of different populations and standardization of image analysis is urgently needed to establish such reference distributions.

show abstract

Section: Discussionmentioning

confidence: 99%

Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis

Raisi‐Estabragh

Kenawy

Aung

et al. 2020

European Heart Journal - Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“… 10 , 11 In addition, there might also be ethnic differences regarding the relationship between LVH and poor cardiovascular outcomes. 12 , 13 Existing evidence suggests that the relationship between LVH and poor cardiovascular outcomes is strongest among Chinese and Hispanics compared with non‐Hispanic Whites. 13 This could imply that Chinese and Hispanics might benefit more from a risk prediction model for LVH.…”

Section: Introductionmentioning

confidence: 99%

“… 12 , 13 Existing evidence suggests that the relationship between LVH and poor cardiovascular outcomes is strongest among Chinese and Hispanics compared with non‐Hispanic Whites. 13 This could imply that Chinese and Hispanics might benefit more from a risk prediction model for LVH. Nevertheless, to the best of knowledge there are no LVH risk prediction models aimed at Chinese hypertensives.…”

Section: Introductionmentioning

confidence: 99%

Development of a nomogram for screening the risk of left ventricular hypertrophy in Chinese hypertensive patients

Wang

Gong

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

Hypertension is the leading risk factor for cardiovascular diseases and premature mortality worldwide. 1 Recent global trends showed that the prevalence of hypertension has decreased in high-income countries, but increased in low-and middle-income countries. 2 The Status of Hypertension in China published in 2018 revealed that the prevalence of hypertension in Chinese adults is 23.2% and is gradually rising. 3 Left ventricular hypertrophy (LVH) is a common complication of hypertension and is a key mediator between the risk factors and the cardiovascular events. 4 It has been reported that multiple factors, such as blood pressure level, age, obesity, gender, the severity of hypertension, and dietary salt intake, are involved in the development of LVH. 5

show abstract

“…There is, however, evidence for racial differences. Akintoye et al [82] found that the relationship between LV mass and incident cardiovascular disease was strongest among Chinese and Hispanics, and weakest for non-Hispanic Whites.…”

Section: Imaging Biomarkers and Outcome Predictionsmentioning

confidence: 99%

“…These approaches have allowed to characterize early changes in cardiac phenotypes and to find novel associations with cardiac risk factors [5]. Further, they have helped to prognosticate long-term outcomes based on specific imaging biomarkers [6]. This review describes the use of CMR across large-scale prospective population studies, highlights novel associations found in the setting of the wide application of those imaging techniques, and discusses novel automated image analysis strategies to overcome challenges posed by the large amount of data obtained in population-based studies.…”

Section: Introductionmentioning

confidence: 99%

Advances in population-based imaging using cardiac magnetic resonance

Beyer

Petersen

2019

Prog. Biomed. Eng.

View full text Add to dashboard Cite

Large population-based studies have helped to identify cardiovascular risk factors and to understand the natural progression of diseases. Cardiac magnetic resonance (CMR) is the reference method for the assessment of ventricular morphology and function given the low variance between scans. In addition, advanced sequences such as MR tagging, T1 mapping, and late gadolinium enhancement allow to assess regional ventricular function and fibrotic changes. MESA was the first study to use CMR on a large scale in a sample of the general population. Subsequent studies focused on cohorts of particular ethnicities or from certain locations with the Jackson Heart Study looking at African-Americans and the Dallas Heart Study at Dallas County Residents. More recently, the German National Cohort and UK Biobank have started to perform CMRs in a significantly larger number of participants (30,000 and 100,000, respectively). The introduction of CMR into prospective cohort studies has allowed to characterize ventricular remodeling in individuals of different age, sex, and gender and has found associations with new environmental exposures. The ability to detect subclinical changes in asymptomatic individuals has also been highlighted by reports of a high number of missed myocardial infarctions (MI) using CMR. In this review, we discuss the use of CMR in the different large population-based studies and compare the various associations found with left and right ventricular structure and function. In addition, we outline automated image analysis strategies aimed at overcoming challenges posed by the large amount of data in population-based studies.

show abstract

Racial/ethnic differences in the prognostic utility of left ventricular mass index for incident cardiovascular disease

Abstract: Background: Evidence exists for racial/ethnic differences in left ventricular mass index (LVMI).

Cited by 10 publications

References 39 publications

Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis

Variation in left ventricular cardiac magnetic resonance normal reference ranges: systematic review and meta-analysis

Development of a nomogram for screening the risk of left ventricular hypertrophy in Chinese hypertensive patients

Advances in population-based imaging using cardiac magnetic resonance

Contact Info

Product

Resources

About