Racial disparity in incidence patterns and outcome of kidney cancer

Vaishampayan, Ulka N.; Do, Huong; Hussain, Maha; Schwartz, Kendra

doi:10.1016/j.urology.2003.07.010

Cited by 83 publications

(64 citation statements)

References 19 publications

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“…During this period the data coverage expanded from 9 to 11 to 13 regions. 5,8,9 Two of the added regions were Los Angeles County and San JoseMonterey, California, which may have greatly altered the racial/ethnic distribution. On the other hand, this study used a database which contains state-mandated reports of all cancer cases in California since 1988.…”

Section: Databasementioning

confidence: 99%

“…5 Recent epidemiological studies have suggested that the incidence rate of RCC is on the rise, with localized cancer predominantly accounting for the increase. 5,[8][9][10][11][12] Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program showed that the incidence rate of RCC has increased more rapidly in Blacks than Whites and in females than males. 5,8,9 Differences between the survival rates of Black and White patients were also found, but the results were confounded by factors such as socioeconomic disparities, performance status, and co-morbid conditions.…”

Section: Introductionmentioning

confidence: 99%

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Racial/Ethnic and Gender Disparities in Renal Cell Carcinoma Incidence and Survival

et al. 2008

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Purpose-To use a population-based cancer registry to examine trends in renal cell carcinoma (RCC) incidence and survival among four racial/ethnic groups (White, Black, Hispanic, and Asian/ Pacific Islander (A/PI)) and both genders.Materials and Methods-Race/ethnicity, gender, age, staging, length of survival, and cause of death data were analyzed using 39,434 cases of RCC from 1988 to 2004 from the California Cancer Registry. Annual age-adjusted incidence rates and relative survival rates were calculated for the racial/ethnic and gender groups. These rates and the percent of localized cancer were plotted by year, Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and Microsoft Excel® was used to calculate linear regression equations. Median age was also calculated. Z-tests and X 2 -tests were performed to determine p-values. NIH Public AccessResults-A rise in RCC incidence was found, with localized cancer accounting for most of the increase. Blacks had a significantly higher incidence rate (p<0.0001) and lower survival rate (p<0.0001) than all other races/ethnicities, despite having more localized cancer (p<0.005). Blacks were also diagnosed at a younger age (p<0.0001) than their counterparts. On the other hand, A/PI's had a lower incidence rate (p<0.0001) and higher survival rate (p<0.05) than all other races/ ethnicities. Males had approximately twice the incidence rate of females and a lower survival rate (p<0.005).Conclusions-Higher incidence rates and lower survival rates were identified among Blacks and males when compared to their counterparts, while A/PI's showed the opposite trends. Such racial/ ethnic and gender disparities in RCC incidence and survival may help elucidate biological, behavioral, and environmental factors that can potentially be addressed.

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Section: Databasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Racial/Ethnic and Gender Disparities in Renal Cell Carcinoma Incidence and Survival

et al. 2008

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“…It also has been demonstrated that race influences the distribution of histologic subtypes, with black patients having increased frequency of papillary kidney cancer [3,7]. While black patients may present at an earlier disease stage [8][9][10][11], paradoxically, survival appears to be worse [10,12]. Even …”

Section: Introductionmentioning

confidence: 99%

Racial disparities in renal cell carcinoma: a single‐payer healthcare experience

Mafolasire

Yao²,

Nawaf

et al. 2016

Cancer Medicine

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Significant racial disparities in survival for renal cell carcinoma (RCC) exist between white and black patients. Differences in access to care and comorbidities are possible contributors. To investigate if racial disparities persist when controlling for access to care, we analyzed data from a single-payer healthcare system. As part of a case-control study within the Kaiser Permanente Northern California system, pathologic and clinical records were obtained for RCC cases (2152 white, 293 black) diagnosed from 1998 to 2008. Patient demographics, comorbidities, tumor characteristics, and treatment status were compared. Overall survival and disease-specific survival (DSS) were calculated by the Kaplan-Meier method. A Cox proportion hazards model estimated the independent associations of race, comorbidity, and clinicopathologic variables with DSS. We found that compared to white patients, black patients were diagnosed at a younger age (median 62 vs. 66 years, P < 0.001), were more likely to have papillary RCC (15% vs. 5.2%, P < 0.001), and had similar rates of surgical treatment (78.8% vs. 77.9%, P = 0.764). On multivariate analysis, advanced American Joint Committee on Cancer (AJCC) stage, lack of surgical treatment, larger tumor size, and higher grade were predictors of worse DSS. Race was not an independent predictor of survival. Therefore, we conclude that within a single healthcare system, differences in characteristics of black and white patients with RCC persist; black patients had different comorbidities, were younger, and had decreased tumor stage. However, unlike other series, race was not an independent predictor of DSS, suggesting that survival differences in large registries may result from barriers to healthcare access and/or comorbidity rather than disease biology. Cancer Medicine Open Access 2102

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“…5,6 About twice as many men as women are diagnosed with RCC. 4,5,7,8 80% of RCCs are diagnosed in patients aged between 40 and 69 years with an average age in the low 60s. 9,10 Worldwide, the incidence of total kidney cancer and simultaneously RCC has steadily increased over the last 2 decades, while the mortality has decreased.…”

Section: Introductionmentioning

confidence: 99%