Racial Disparities in the Clinical Presentation and Prognosis of Patients with Mycosis Fungoides

Huang, Amy; Kwatra, Shawn G.; Khanna, Raveena; Semenov, Yevgeniy R.; Okoye, Ginette A.; Sweren, Ronald J.

doi:10.1016/j.jnma.2019.08.006

Cited by 20 publications

(20 citation statements)

References 13 publications

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“…Our African American cohort also tended to be younger than the Caucasian group ( Figure 2). These are similar to the observations of Huang et al and are important since African Americans with MF have been found to have significantly shorter overall survival when compared with age at onset-, stage-and treatment-matched Caucasian patients [17,20].…”

Section: Discussionsupporting

confidence: 90%

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

et al. 2019

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Background: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma. Previous reports have suggested MF is associated with inflammatory conditions such as psoriasis, increased cardiovascular risk factors as well as secondary neoplasms. Methods: A cross-sectional study of MF patients seen from 2013 to 2019 was performed. Comorbidities were selected based on the 2015 Medicare report highlighting the most common chronic medical illnesses in the United States. Lifetime comorbidity occurrence in patients with MF were compared with that in patients with atopic dermatitis, psoriasis and patients without MF. Additional analyses were performed with patients sub-stratified by race. Results: Compared to control groups, MF was strongly associated with lymphomatoid papulosis and Hodgkin’s disease, but not significantly associated with lung, breast or colon cancer. Interestingly, the association with lymphomatoid papulosis was observed in Caucasians (CI 1062-4338; p < 0.001) and not African Americans (p = 0.9). Patients with MF had a greater association with congestive heart failure, hypertension (HT) and hyperlipidemia (HLD) compared with the general population. However, they were significantly less likely to have HT and HLD when compared with psoriasis patients (HT CI: 0.6–0.9; p < 0.001, and HLD CI: 0.05–0.07; p < 0.001). MF patients were also significantly less likely to have concomitant vitamin D deficiency compared with atopic dermatitis (AD) and psoriasis (p < 0.001). Conclusions: Our results suggest that the association of MF with lymphomatoid papulosis varies by race. Compared to the general population, hypertension and hyperlipidemia were positively associated with MF, however, these were significantly less likely on comparison to psoriasis. Unlike previously described, vitamin D deficiency was found to be significantly less in patients with MF.

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Section: Discussionsupporting

confidence: 90%

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

et al. 2019

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“…Another skin condition featured in this special Issue is mycosis fungoides (MF). Patients with MF experience increased rates of cardiovascular disease and mortality when compared to healthy controls [8,9]. Recent studies have shown a relationship between MF and inflammatory disorders like psoriasis [9,10].…”

Section: Epidemiologymentioning

confidence: 99%

Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again

Williams

Kwatra

2020

Medicines

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“…It still remains unclear whether chronic inflammatory skin diseases, including atopic dermatitis, eczema, and psoriasis, or chronic exposure to chemical agents represent risk factors for MF [9,18,19]. Skin of color seems not to be a predisposing factor [20].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Update of the Atypical, Rare and Mimicking Presentations of Mycosis Fungoides

Lebas

Collins

Somja

et al. 2021

Dermatol Ther (Heidelb)

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Racial Disparities in the Clinical Presentation and Prognosis of Patients with Mycosis Fungoides

Cited by 20 publications

References 13 publications

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

Emerging Research in Chronic Pruritus: From Bedside to Bench and Back Again

A Comprehensive Update of the Atypical, Rare and Mimicking Presentations of Mycosis Fungoides

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