Racial Disparities in Prostate Cancer–Specific Mortality in Men With Low-Risk Prostate Cancer

Mahal, Brandon A.; Aizer, Ayal A.; Ziehr, David R.; Hyatt, Andrew S.; Choueiri, Toni K.; Hu, Jim C.; Hoffman, Karen E.; Sweeney, Christopher J.; Beard, Clair J.; D’Amico, Anthony V.; Martin, Neil E.; Kim, Simon P.; Trinh, Quoc Dien; Nguyen, Paul L.

doi:10.1016/j.clgc.2014.04.003

Cited by 45 publications

(25 citation statements)

References 31 publications

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“…This finding differs from previous studies, many of which use SEER-Medicare data, 4,8 that have demonstrated racial differences in receipt of definitive treatment. It is likely that this difference results from our in-depth focus on a single region.…”

Section: Discussioncontrasting

confidence: 55%

“…Black men are at least 1.4 times more likely to be diagnosed with prostate cancer 3 and 2.4 times more likely to die from the disease compared with White men. 4,5 Despite higher incidence and mortality, 6,7 Black men remain significantly less likely to receive definitive treatment 4,8,9 and less likely to undergo radical prostatectomy. 4,8,10,11 The reasons why Black men are less likely to receive definitive treatment and radical prostatectomy are poorly understood and likely multifactorial.…”

Section: Introductionmentioning

confidence: 99%

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Racial Differences in Prostate Cancer Treatment: The Role of Socioeconomic Status

et al. 2017

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Objective: This study examines whether socioeconomic status (SES), measured at both the individual and neighborhood levels, is associated with receipt of definitive treatment for localized prostate cancer and whether these associations mediate racial differences in treatment between non-Hispanic White and non-Hispanic Black men. Design: The Philadelphia Area Prostate Cancer Access Study (P2 Access) is a mailed, cross-sectional survey of men sampled from the Pennsylvania Cancer Registry, combined with neighborhood Census data. Setting: Eight counties in southeastern Pennsylvania. Participants: 2,386 men with prostate adenocarcinoma. Main Measures: Receipt of definitive treatment, race, self-reported income, education, employment status, and neighborhood SES. Results: Overall, Black and White men were equally likely to receive definitive treatment. Men living in neighborhoods with higher SES were more likely to receive definitive treatment (OR 1.57, 95%CI 1.01, 2.42). Among men who received definitive treatment, Black men were significantly less likely to receive radical prostatectomy compared with White men (OR .71, 95% CI .52, .98), as were men with some college education compared with those with a high school education or less (OR .66, 95% CI .47, .94). SES does not mediate racial differences in receipt of definitive treatment or the type of definitive treatment received, and associations with income or employment status were not significant. Conclusions: These results stress the importance of examining racial disparities within geographic areas and highlight the unique associations that different measures of SES, particularly neighborhood SES and education, may have with prostate cancer treatment.Ethn Dis. 2017;27(3):201-208; doi:10.18865/ed.27.3.201.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Racial Differences in Prostate Cancer Treatment: The Role of Socioeconomic Status

et al. 2017

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“…4 Interestingly, AA men show a higher likelihood of progression and mortality on active surveillance for PCa. 25 Data from the Johns Hopkins group suggest that failure on surveillance for AA men may result from adverse pathologic features as demonstrated in low-risk AA men at the time of radical prostatectomy. 9 Unfortunately, we could not verify any relationship between low serum vitamin D levels and adverse pathology on ethnicity-stratified univariate or multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

Nyame

Bowen

Jordan

et al. 2016

JCO

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Purpose Lower serum Vitamin D levels has demonstrated associations with increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low- or intermediate risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study is to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin (25-OH D) levels. Patients and Methods This is a cross-sectional study from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extra-prostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results 45.8 % (87/190) of men in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (IQR 59.0–67.0). On univariate analysis men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 vs 27.0 ng/ml, p = 0.007) when compared to their counterparts. On multivariate analysis controlling for age, serum PSA, and suspicious digital rectal examination, serum 25-OH D < 30 ng/mL was associated with increased odds of adverse pathology (OR 2.64, 95% CI 1.25, 5.59, p = 0.01). Conclusion Insufficiency/Deficiency in serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study.

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“…Racial disparities in male cancers such as prostate (Mahal et al 2014;Siegel et al 2014b) and colorectal (Siegel et al 2014a;Wallace et al 2013) are well documented. However, less is known about differences in clinical characteristics in nH black and white males diagnosed with HNSCCs, or about whether such differences have changed over time.…”

Section: Introductionmentioning

confidence: 99%

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

Peterson

Khosla

Chen

et al. 2016

J Cancer Res Clin Oncol

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Racial Disparities in Prostate Cancer–Specific Mortality in Men With Low-Risk Prostate Cancer

Cited by 45 publications

References 31 publications

Racial Differences in Prostate Cancer Treatment: The Role of Socioeconomic Status

Racial Differences in Prostate Cancer Treatment: The Role of Socioeconomic Status

Associations Between Serum Vitamin D and Adverse Pathology in Men Undergoing Radical Prostatectomy

Racial differences in head and neck squamous cell carcinomas among non-Hispanic black and white males identified through the National Cancer Database (1998–2012)

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