Racial Disparities in Diagnosis and Management of Benign Prostatic Hyperplasia: A Review

Ayangbesan, Abimbola; Kavoussi, Nicholas

doi:10.1007/s11934-022-01118-5

Cited by 2 publications

(4 citation statements)

References 53 publications

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“…In the United States, the Prostate Cancer Prevention Trial reported a 41% increased incidence risk of Black and Hispanic men having BPH/LUTS compared to that of White men 1,83 . Furthermore, the risk of progressing from mild to moderate/severe BPH were 68% higher than White men 83 .…”

Section: Discussionmentioning

confidence: 99%

“…In the United States, the Prostate Cancer Prevention Trial reported a 41% increased incidence risk of Black and Hispanic men having BPH/ LUTS compared to that of White men. 1,83 Furthermore, the risk of progressing from mild to moderate/severe BPH were 68% higher than White men. 83 In the Flint Men's Health Study of African American men, although 37% had moderate-to-severe LUTS impairment, only 8.2% were diagnosed with BPH before the study and 3% reported being medically treated for BPH.…”

Section: Racial Disparities and Circadian Rhythm Association In Bph/lutsmentioning

confidence: 98%

“…Benign prostatic hyperplasia (BPH) is a condition that affects the aging male population, with onset of symptoms occurring around age 50. This urologic disease affects over 200 million men worldwide, and in the United States, accounts for about 23 million clinic visits and 1.2 million emergency department (ED) visits 1 . By the age 80, over 80% of men are diagnosed with BPH, 2 deeming it the most common urologic disease in men 3 .…”

Section: Introductionmentioning

confidence: 99%

“…This urologic disease affects over 200 million men worldwide, and in the United States, accounts for about 23 million clinic visits and 1.2 million emergency department (ED) visits. 1 By the age 80, over 80% of men are diagnosed with BPH, 2 deeming it the most common urologic disease in men. 3 BPH is characterized as an enlargement of the prostate gland due to the proliferation of prostatic stromal and epithelial cells in the transitional zone.…”

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confidence: 99%

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Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)

Cavanaugh,

Urbanucci,

Mohamed

et al. 2024

The Prostate

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BackgroundBenign prostatic hyperplasia (BPH) is the most common urologic disease in aging males, affecting 50% of men over 50 and up to 80% of men over 80 years old. Its negative impact on health‐related quality of life implores further investigation into its risk factors and strategies for effective management. Although the exact molecular mechanisms underlying pathophysiological onset of BPH are poorly defined, the current hypothesized contributors to BPH and lower urinary tract symptoms (LUTS) include aging, inflammation, metabolic syndrome, and hormonal changes. These processes are indirectly influenced by circadian rhythm disruption. In this article, we review the recent evidence on the potential association of light changes/circadian rhythm disruption and the onset of BPH and impact on treatment.MethodsA narrative literature review was conducted using PubMed and Google Scholar to identify supporting evidence. The articles referenced ranged from 1975 to 2023.ResultsA clear relationship between BPH/LUTS and circadian rhythm disruption is yet to be established. However, common mediators influence both diseases, including proinflammatory states, metabolic syndrome, and hormonal regulation that can be asserted to circadian disruption. Some studies have identified a possible relationship between general LUTS and sleep disturbance, but little research has been done on the medical management of these diseases and how circadian rhythm disruption further affects treatment outcomes.ConclusionsThere is evidence to implicate a relationship between BPH/LUTS and circadian rhythm disruptions. However, there is scarce literature on potential specific link in medical management of the disease and treatment outcomes with circadian rhythm disruption. Further study is warranted to provide BPH patients with insights into circadian rhythm directed appropriate interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Racial Disparities and Circadian Rhythm Association In Bph/lutsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)

Cavanaugh,

Urbanucci,

Mohamed

et al. 2024

The Prostate

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Safety and complications of continuation of aspirin therapy in patients undergoing robot-assisted laparoscopic simple prostatectomy

Saini,

Thakker,

Ritts

et al. 2024

J Robotic Surg

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To evaluate the safety and feasibility of continued perioperative aspirin at the time of robotic assisted simple prostatectomy (RASP). We performed a retrospective review of our IRB approved institutional database of patients who underwent RASP between 2013 and 2022. Comparative groups included patients taking aspirin in the perioperative period and those not taking aspirin pre-operatively. The primary outcome was any post-operative bleeding related complication using the modified Clavien–Dindo classification. Secondary outcomes included the identification of risk factors for increased blood loss in the entire study population, operative time, and blood transfusion requirement. 143 patients underwent RASP of which 55 (38.5%) patients continued perioperative aspirin therapy and 88 (61.5%) patients did not. Baseline demographics were similar between groups. Patients taking perioperative aspirin had a higher rate of hypertension (74.5% vs 58.0%, p = 0.04) and other cardiovascular disease (30.9% vs 11.4%, p = 0.007). Postoperative complications were similar between the groups (Clavien-Dindo ≥ 3; p = 0.43). Median blood loss (150 cc vs 150 cc, p = 0.38), percentage drop in hemoglobin (13.4 vs 13.2, p = 0.94) and blood transfusion rate (3.6 vs 1.1, p = 0.56) were also similar between groups. The median blood loss was 150 ml for the whole study population. On regression analysis, neither aspirin nor any other variable was associated with increased blood loss (> 150 ml). Aspirin can be safely continued perioperatively in patients undergoing RASP without any risk of bleeding related complications, blood loss, or increased transfusion rate.

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Racial Disparities in Diagnosis and Management of Benign Prostatic Hyperplasia: A Review

Cited by 2 publications

References 53 publications

Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)

Link between circadian rhythm and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS)

Safety and complications of continuation of aspirin therapy in patients undergoing robot-assisted laparoscopic simple prostatectomy

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