Racial Disparities Differ for African Americans and Hispanics in the Diagnosis and Treatment of Penile Cancer

Slopnick, Emily; Kim, Simon P.; Kiechle, Jonathan E.; Gonzalez, Christopher; Zhu, Hui; Abouassaly, Robert

doi:10.1016/j.urology.2016.06.048

Cited by 15 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the study by Sharma et al, black males who were suffered from PC would have a worse OS [26]. In addition, Slopnick et al declared that African-American PC patients probably had a higher risk of death compared with the white [27]. However, in our study, both in the result of cox regression and Kaplan-Meier curve, no signi cant difference was found in the comparison among white, black and other races.…”

Section: Discussioncontrasting

confidence: 61%

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Gao

Tang

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: We aimed to establish a prognostic nomogram for Penile Cancer (PC) patients based on the Surveillance, Epidemiology, and End Results Program (SEER) database.Methods: Data of 1694 patients between 2010 and 2015 were downloaded and extracted from the SEER database. Then, they were randomly divided into the development group (70%) and the verification group (30%). Following, the univariate and multivariate Cox proportional hazards regression was respectively used to explore the possible risk factors of PC. Factors which significantly related to the overall survival (OS) were used to establish the nomogram. Further, the concordance index (C-index), receiver operating characteristic curve (ROC) and calibration curve were used to assess the nomogram, respectively. An internal validation was carried out to test the accuracy and effectiveness of nomogram. Finally, the Kaplan-Meier calculation was used to predict the further survival status of these patients.Results: Multivariate Cox proportional hazards regression demonstrated that the independent prognostic risk factors associated with PC were age, stage T, N and M, and grade, with a moderate c-index of 0.732 [95% confidence interval (CI), 0.706-0.757] in development group and 0.743 (95% CI, 0.703-0.782) in verification group. Meanwhile, the areas under the ROC (AUC) of 3-year and 5-year survival were 0.739 and 0.727, respectively. The survival calibration curves of 3-year and 5-year brought out a high consistency. Conclusion: Our study obtained a satisfactory nomogram to reveal the survival of PC patients, which could be helpful for clinicians to assess the situation of PC patients and to implement the further treatment.

show abstract

Section: Discussioncontrasting

confidence: 61%

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Gao

Tang

Guo

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In other studies, Hispanic and African American men have been reported to have the highest age-adjusted rates of penile cancer compared with whites, Asians, or American Indians. 9,12 The highest rates of penile cancer were observed in Hispanic and African American men older than 85 years of age, but penile cancer was rare among males younger than 20 years of age. Analyses to assess temporal trends from 1995 to 2003 revealed a statistically significant decline in the incidence of penile cancer for African Americans and whites.…”

Section: Incidencementioning

confidence: 99%

Disparities in Penile Cancer

Zargar‐Shoshtari

Pettaway²,

Schabath

et al. 2016

Cancer Control

View full text Add to dashboard Cite

show abstract

“…10 Slopnick et al showed that Black men are less likely to undergo surgical management of their disease, which correlates with worse survival. 11 Socioeconomic factors such as uninsured status, lower education and nonmetropolitan residence have also been found to be poor prognostic factors for men with penile cancer. 10,12,13 Studies in other urologic cancers, such as bladder and prostate cancer, have shown that Black men are less likely to get SOC for localized disease.…”

mentioning

confidence: 99%

Underutilization of Surgical Standard of Care for Insured Men with Invasive Penile Cancer

et al. 2021

View full text Add to dashboard Cite

Introduction: Prior studies of mixed insurance populations have demonstrated poor adherence to surgical standard of care for penile cancer. We used data from the Surveillance, Epidemiology and End Results (SEER) cancer registry linked to Medicare to calculate standard of care adherence to surgical treatment of penile cancer in insured men over the age of 65, focusing on potential social and racial disparities.Methods: This is an observational analysis of patients with T2-4 penile cancer of any histologic subtype without metastasis in the SEER-Medicare database (2004e2015). Standard of care was defined as penectomy (partial or radical) with bilateral inguinal lymph node dissection based on the National Comprehensive Cancer Network guidelines. We calculated proportions of those receiving standard of care and constructed multivariate models to identify factors associated with receiving standard of care.Results: A total of 447 men were included. Of these men 22.1% (99/447) received standard of care while 18.8% (84/447) received no treatment at all. Only 23.3% (104/447) had inguinal lymph node dissection while 80.9% (362/447) underwent total or partial penectomy. Race and socioeconomic status were not associated with decreased standard of care. Increasing age (OR 0.93, 95% CI 0.89e0.96), Charlson Comorbidity Index score 2 (OR 0.53, 95% CI 0.29e0.97) and T3 to T4 disease (OR 0.34, 95% CI 0.18e0.65) were associated with not receiving standard of care on adjusted analysis.Conclusions: Rates of standard of care are low among insured men 65 years of age or older with invasive penile cancer, regardless of race or socioeconomic status. This finding is largely driven by low rates of inguinal lymph node dissection. Strategies are needed to overcome barriers to standard of care treatment for men with invasive penile cancer.

show abstract

Racial Disparities Differ for African Americans and Hispanics in the Diagnosis and Treatment of Penile Cancer

Cited by 15 publications

References 18 publications

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Prognostic Nomogram for Penile Cancer, an Analysis Based on SEER Database

Disparities in Penile Cancer

Underutilization of Surgical Standard of Care for Insured Men with Invasive Penile Cancer

Contact Info

Product

Resources

About