Racial Differences in the Extracellular Matrix and Histone Acetylation of the Lamina Cribrosa and Peripapillary Sclera

Kim, Joo Hang; Jung, Younhea

doi:10.1167/iovs.17-21474

Cited by 10 publications

(5 citation statements)

References 49 publications

(49 reference statements)

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“…We observed nuclear and cytoplasmic staining of HDAC2 and HDAC3 in the axons and glia of the optic nerve head; other studies have previously noted staining with these HDACs in the human lamina cribrosa beams and fibroblasts of the peripapillary sclera [34].…”

Section: Discussionsupporting

confidence: 70%

Tumour Expression of Histone Deacetylases in Uveal Melanoma

et al. 2018

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Purpose: To determine the expression of histone deacetylase enzymes in uveal melanoma tumour cells. Procedures: This is an observational immunohistochemical study of 16 formalin-fixed, paraffin-embedded eyes enucleated for uveal melanoma between January 2001 and March 2002. Haematoxylin and eosin paraffin sections were reviewed for histopathological parameters according to the American Joint Committee on Cancer 7th edition. Sections were then immunohistochemically stained for histone deacetylases 1, 2, 3, 4 and 6 and sirtuin 2 using an automated Leica Bond II platform and Fast Red chromogen, then digitally scanned using Aperio software before assessment of staining. Results: Nuclear expression of histone deacetylases 1, 2, 3, 4 and 6 and of sirtuin 2 was confirmed in uveal melanoma tumour cells. In addition, the tumour cells showed cytoplasmic expression of histone deacetylases 4 and 6 and sirtuin 2. Nuclear and cytoplasmic immunostaining was also seen in intraocular tissues uninvolved by the tumour. Conclusion: Uveal melanoma tumour cells express histone deacetylases 1, 2, 3, 4 and 6 and sirtuin 2, confirming potential tissue targets for histone deacetylase inhibitors.

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Section: Discussionsupporting

confidence: 70%

Tumour Expression of Histone Deacetylases in Uveal Melanoma

et al. 2018

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“…Hypotony in the early postoperative period after the XEN procedure is relatively common, which seems to happen owing to peritubular flow created by the difference between the diameter of XEN and the lumen diameter of the injector needle containing XEN gel stent. In addition, the higher rate of early hypotony in our study can be further elucidated by the ethnic difference in the scleral elasticity between Korean and Caucasian populations, as reported by Park et al 16 …”

Section: Discussionsupporting

confidence: 74%

Bleb Analysis Using Anterior Segment Optical Coherence Tomography and Surgical Predictors of XEN Gel Stent

Kim

Lim²,

Rho

2022

Trans. Vis. Sci. Tech.

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Purpose To determine the early predictors of surgical success 6 months after XEN surgery among clinical parameters, including anterior segment optical coherence tomography (AS-OCT). Methods A total of 31 eyes with medically uncontrolled primary open-angle glaucoma or pseudoexfoliation glaucoma was enrolled retrospectively. Using AS-OCT, XEN tip location was categorized into intraconjunctival, intratenon, or uviform at day 1 and blebs were classified into no or low, high sparse, high thick, cystic, or mixed walls at month 6. Using slit-lamp photography, blebs were classified into no or low, localized avascular, diffuse avascular, localized vascular, or diffuse vascular blebs at month 6. Surgical success was defined as an intraocular pressure (IOP) of less than 14 mm Hg. Results Intraconjunctival and intratenon locations of the tip mostly created a high sparse wall, whereas the uviform type mostly created no or low wall and no or low bleb. The uviform type was linked to pseudoexfoliation glaucoma. A high sparse wall and diffuse avascular bleb showed a lower mean IOP than a high thick wall and localized vascular bleb. In the multivariate analysis, female sex and IOP at week 1 were early predictors of surgical success (8.45 times and 33.1% per 1 mm Hg-decrease, respectively). Conclusions Bleb evaluation using AS-OCT is valuable to correlate tip location and bleb morphology with clinical profiles, considering that a lower early postoperative IOP is linked to surgical success. Translational Relevance Bleb analysis using AS-OCT on day 1 could help to predict bleb morphology after 6 months, which is important to maintain the functioning bleb in the longer term.

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“…TCF3 is associated with retinitis pigmentosa by forming HAND1::TCF3 complex and regulating the expression of retinal degeneration-related genes (Kaukonen et al, 2020 ). HDAC2 is one of histone deacetylase, whose downregulation is implicated in the pathogenesis of glaucoma by epigenetic regulation of extracellular matrix (ECM) genes (Park et al, 2017 ). Thus, downregulation of these broad-acting transcriptional regulators may result in disturbed epigenetic/transcriptional regulation networks, which by feeding into aberrant downstream cascades may contribute to retinal aging and related diseases in the aged retina.…”

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confidence: 99%