Racial Differences in the Cause-Specific Prevalence of Blindness in East Baltimore

Sommer, Alfred; Tielsch, James M.; Katz, Joanne; Quigley, Harry A.; Gottsch, John D.; Javitt, Jonathan C.; Martone, James F.; Royall, Richard M.; Witt, Kathe A.; Ezrine, Sandi

doi:10.1056/nejm199111143252004

Cited by 673 publications

(361 citation statements)

References 20 publications

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“…Age-related macular degeneration (AMD) is a major cause of irreversible loss of central vision among persons over the age of 55 and among U.S. veterans [1][2][3][4][5]. Approximately 70 percent of cases of severe visual loss in AMD are due to growth of abnormal blood vessels from the choriocapillaris into the subretinal space.…”

Section: Introductionmentioning

confidence: 99%

Migration and proliferation of retinal pigment epithelium on extracellular matrix ligands

Wang¹,

Patten²,

Sugino³

et al. 2006

JRRD

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Abstract-We compared aged adult and fetal retinal pigment epithelium (RPE) migration and proliferation in cell culture. Aged adult RPE resurfaced on dishes coated with human or mouse laminin, human or rat collagen I, human or mouse collagen IV, or human fibronectin. Resurfacing was best on bovine corneal endothelial cell extracellular matrix. Resurfacing was worst on mouse laminin. Fetal RPE resurfacing was robust on all surfaces studied except human and mouse laminin. In general, fetal RPE resurfacing was much greater than that seen with aged RPE on comparable surfaces. The degree of cell proliferation (labeled by Ki-67) was much greater in fetal than adult RPE cells.

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Section: Introductionmentioning

confidence: 99%

Migration and proliferation of retinal pigment epithelium on extracellular matrix ligands

Wang¹,

Patten²,

Sugino³

et al. 2006

JRRD

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“…2 At least one-third of all cases may have a genetic basis, 3 either as part of a multisystem disease or, more frequently, as a nonsyndromic Mendelian trait. 4 All three classical forms of Mendelian inheritance have been reported, with the majority of cases exhibiting autosomal dominant transmission.…”

Section: Introductionmentioning

confidence: 99%

Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q

2003

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Hereditary cataract is a clinically and genetically heterogeneous lens disease that accounts for a significant proportion of visual impairment and blindness in childhood. The alphaA-crystallin (CRYAA) gene (CRYAA) encodes a member of the small-heat-shock protein (sHSP) family of molecular chaperones and is primarily and abundantly expressed in the ocular lens. Here, we have used linkage analysis to identify a novel missense mutation in CRYAA that underlies an autosomal dominant form of 'nuclear' cataract segregating in a four-generation Caucasian family. A maximum two-point LOD score (Z max ) of 2.19 (maximum recombination fraction, h max ¼ 0) and multipoint Z max of 3.3 (h max ¼ 0) was obtained at marker D21S1885. Haplotype analysis indicated that the disease gene lay in the B2.7 Mb physical interval between D21S1912 and D21S1260 flanking CRYAA on 21q22.3. Sequence analysis identified a C-T transition in exon 1 of CRYAA from affected individuals that was predicted to result in the nonconservative substitution of cysteine for arginine at codon 49 (R49C). Transfection studies of lens epithelial cells revealed that, unlike wild-type CRYAA, the R49C mutant protein was abnormally localized to the nucleus and failed to protect from staurosporine-induced apoptotic cell death. This study has identified the first dominant cataract mutation in CRYAA located outside the phylogenetically conserved 'alpha-crystallin core domain' of the sHSP family.

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“…Blacks are more likely to have glaucoma than Whites; the disease is one of the leading causes of blindness in this group. 4,5 Given the significant individual and economic consequences of glaucoma, prevention strategies are essential if we hope to decrease the burden of this eye condition.…”

mentioning

confidence: 99%

Glaucoma Risk and the Consumption of Fruits and Vegetables Among Older Women in the Study of Osteoporotic Fractures

Coleman

Stone

Kodjebacheva

et al. 2008

American Journal of Ophthalmology

102

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Racial Differences in the Cause-Specific Prevalence of Blindness in East Baltimore

Cited by 673 publications

References 20 publications

Migration and proliferation of retinal pigment epithelium on extracellular matrix ligands

Migration and proliferation of retinal pigment epithelium on extracellular matrix ligands

Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q

Glaucoma Risk and the Consumption of Fruits and Vegetables Among Older Women in the Study of Osteoporotic Fractures

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