Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study

Eley, J. William

doi:10.1001/jama.272.12.947

Cited by 296 publications

(272 citation statements)

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“…[23][24][25][26][27][28][29] However, the results of the current study support results of a study by Wojcik et al 30 who reported that survival remains significantly worse for African-American women even with equivalent treatment. In the Wojcik et al study, survival was significantly better for patients who received BCS with radiation therapy than for those who received BCS alone.…”

Section: Discussionsupporting

confidence: 85%

Racial differences in treatment and survival from early‐stage breast carcinoma

Joslyn

2002

Cancer

108

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BACKGROUNDAfrican‐American women have a significantly worse prognosis from breast carcinoma compared with white women, even when the stage at diagnosis is equivalent. The purpose of this study was to analyze racial differences in the treatment (use of breast‐conserving surgery and radiation therapy) of women with early‐stage breast carcinoma and the resulting effects on survival rates.METHODSSubjects included 10,073 African‐American and 123,127 white women diagnosed with Stage I, IIA, or IIB breast carcinoma in the National Cancer Institute's Surveillance, Epidemiology, and End Results program between 1988 and 1998. Comparisons were made by race with treatment, age, hormone receptor status, and stage at the time of diagnosis. Survival analyses were conducted to compare risk of death for African‐American and white women while controlling for age, stage, and hormone receptor status.RESULTSAmong women diagnosed with early‐stage breast carcinoma who receive breast‐conserving surgery, African‐American women were significantly less likely to receive follow‐up radiation therapy in every 10‐year age group except in the older than 85 age group. Whether treatment was equivalent or suboptimal, survival for African‐American women with early‐stage breast carcinoma was significantly worse. However, when treatment was equivalent, the effects of racial differences on survival were significantly less compared with survival associated with suboptimal treatment.CONCLUSIONSSignificant racial differences exist in the treatment of women with early‐stage breast carcinoma. Public health efforts to eliminate suboptimal treatment would reduce, but not eliminate, racial disparity in survival. Cancer 2002;95:1759–66. © 2002 American Cancer Society.DOI 10.1002/cncr.10827

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Section: Discussionsupporting

confidence: 85%

Racial differences in treatment and survival from early‐stage breast carcinoma

Joslyn

2002

Cancer

108

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“…In contrast to these findings from UK, extensive research from the USA suggested significantly poorer survival in African Americans (Eley et al, 1994). However, in a study comparing breast cancer patients who had equivalent stage disease and were Breast cancer outcomes in Yorkshire G Velikova et al treated uniformly in a single institution, race did not influence outcome (Heimann et al, 1997).…”

Section: Discussionmentioning

confidence: 92%

“…For example, the uptake of breast cancer screening is relatively low (Bahl, 1996;Hoare, 1996). Large studies from the USA show ethnic differences in survival after breast cancer, with survival among African-American women significantly worse than white women (Eley et al, 1994). The outcomes of breast cancer treatment in ethnic minority groups in the UK have rarely been formally studied (Selby, 1996;McKinney et al, 1999).…”

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confidence: 99%

Breast cancer outcomes in South Asian population of West Yorkshire

et al. 2004

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“…Ethnic differences in survival from breast cancer have also been reported in the USA (Young et al, 1981;Richardson et al, 1992;Eley et al, 1994;Hsu et al, 1997;Hunter, 2000) but have never been examined in Britain. South Asian ethnic populations (i.e.…”

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confidence: 97%

Survival from breast cancer among South Asian and non-South Asian women resident in South East England

et al. 2003

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Ethnic differences in breast cancer survival have been observed in the USA but have not been examined in Britain. We aimed to investigate such differences between South Asian (i.e. those with family roots in the Indian subcontinent) and non-South Asian (essentially British-native) women in England. Primary breast cancer cases incident in 1986 -1993 and resident in South East England were ascertained through the Thames Cancer and Registry and followed up to the end of 1997. Cases of South Asian ethnicity were identified on the basis of their names by using a previously validated computer algorithm. A total of 1037 South Asian and 50 201 non-South Asian breast cancer cases were included in the analysis; 30% of the South Asian (n ¼ 312) and 44% (n ¼ 22 201) of the non-South Asian cases died during follow-up. South Asian cases had a higher relative survival than non-South Asians throughout the follow-up period. The 10-year relative survival rates were 72.6% (95% confidence interval: 69.0, 75.9%) and 65.2% (64.5, 65.8%) for South Asians and non-South Asians, respectively. The excess mortality rates experienced by South Asians were 82% (72, 94%) of those experienced by non-South Asians (P ¼ 0.004). The magnitude of this effect was slightly reduced with adjustment for differences in age at diagnosis, but was strengthened with further adjustment for differences in stage at presentation and socioeconomic deprivation (excess mortality rates in South Asians relative to non-South Asians ¼ 72% (63, 82%), Po0.001). These findings indicate that the higher survival from breast cancer in the first 10 years after diagnosis among South Asian was not due to differences in age at diagnosis, socioeconomic deprivation or disease stage at presentation.

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Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study

Cited by 296 publications

References 0 publications

Racial differences in treatment and survival from early‐stage breast carcinoma

Racial differences in treatment and survival from early‐stage breast carcinoma

Breast cancer outcomes in South Asian population of West Yorkshire

Survival from breast cancer among South Asian and non-South Asian women resident in South East England

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