Objective
To examine the effect of the COVID-19 pandemic on maternal substance abuse and neonatal outcomes.
Study design
Cross-sectional observational study of neonates admitted to the NICU and born to mothers with evidence of substance abuse pre-pandemic compared to during the COVID-19 pandemic.
Result
We noted a significant increase in fentanyl (12% vs. 0.6%,
p
< 0.001) and tobacco use (64% vs. 33%,
p
< 0.001) during the pandemic compared to pre-pandemic, including an increase in fentanyl use among mothers enrolled in opioid maintenance therapy (OMT) during the pandemic (32.3% vs. 1.5%,
p
< 0.001). There was a significant increase in preterm births (58% vs. 48%,
p
= 0.022) and lower birth weight (2315 ± 815 vs. 2455 ± 861 g,
p
= 0.049) during pandemic.
Conclusion
There was a significant increase in maternal fentanyl use during the pandemic, even with OMT enrollment, with an increase in preterm births and lower birth weights among infants born to mothers with substance use.