Racial differences in hospitalizations for acute cholangitis: a nationwide time trend analysis, 2008-2018

Abstract

Background The data on racial epidemiologic trends for acute cholangitis (AC) are scarce. Therefore, we conducted a longitudinal assessment of the racial breakdown of AC-related hospitalizations in the United States (US) over 11 years (2008-2018). Methods Using the National Inpatient Sample, we retrieved adult (>18 years) patients with AC. The adjusted yearly hospitalization rate per 100,000 for each race category was calculated based on the US population estimate for July 1 of the corresponding year obtained from the US Census Bureau. We followed Healthcare Cost and Utilization Project recommendations to: (1) derive a time-interrupted trend (before and after 2015), after determining that the International Classification of Diseases coding change affected AC hospitalizations because of more specific coding in the tenth revision; and (2) generate proportionate estimates using revised trend weights. Results A total of 321,849 patients with AC were included in the analysis. Before 2015, the overall hospitalizations (per 100,000 persons) increased from 16.03 in 2008 to 20.76 in 2014 (P<0.001). Following 2015, the overall hospitalizations increased from 14.34 in 2016 to 14.70 in 2018 (P=0.04). After Whites, Asians represented the ethnic group with the highest race-specific AC hospitalizations per 100,000 persons. Conclusions This cohort study demonstrated an overall rising and disproportionate rate among different races for AC-related hospitalizations. Even though Asians constitute only 6.5% of the US population, they represent the ethnic minority with most hospitalizations for AC.

Racial Differences in Non-variceal Upper Gastrointestinal (GI) Bleeding: A Nationwide Study

“…Race has been shown to have an impact on the clinical presentation of many diseases, access to certain procedures, and outcomes of these diseases. For example, studies have shown that African Americans have worse outcomes after trauma [4], Asians represent the minority with the most admissions for acute cholangitis [5], and Latinxs and Native Americans have lower odds of undergoing esophagogastroduodenoscopy (EGD) for upper GI bleeding in rural hospitals [6]. Despite an increasing interest in racial differences in upper GI bleeding [7][8][9], the literature is limited on how race affects the etiologies and outcomes of non-variceal upper GI bleeding (NVUGIB).…”

Comparative Analysis of Antibiotic Resistance in Acute Cholangitis Patients with Stent Placement and Sphincterotomy Interventions

“…This condition necessitates a sizable number of emergency surgical interventions [8,9]. Distinct from primary biliary cholangitis, the global incidence of AC stands at approximately 8-12 cases per 100,000 individuals annually [10][11][12]. The wide range of AC patients encountered in healthcare systems underscores the importance of discerning the variables affecting disease progression and outcomes.…”