Racial and Temporal Variations in the Prevalence of Heart Defects

Botto, L.; Correa, Adolfo; Erickson, J. David

doi:10.1542/peds.107.3.e32

Cited by 517 publications

(420 citation statements)

References 20 publications

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“…We25 and others26 have reported the constraints of administrative data sets for detection and categorization of ACHD. Even so, ICD‐9 codes have been used to investigate CHD‐related births and mortality in the United States 27, 28. TOF accounted for the largest number of HF hospitalizations in this study, consistent with prior studies reporting HF as the most common cause of hospitalization in this group 29.…”

Section: Discussionsupporting

confidence: 83%

Hospitalization Trends and Health Resource Use for Adult Congenital Heart Disease–Related Heart Failure

Burchill

Gao

Kovacs

et al. 2018

JAHA

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BackgroundThis study assessed trends in heart failure (HF) hospitalizations and health resource use in patients with adult congenital heart disease (ACHD).Methods and ResultsThe Nationwide Inpatient Sample was used to compare ACHD with non‐ACHD HF hospitalization and health resource trends. Health resource use was assessed using total hospital charges, hospital length of stay, and procedural burden. A total of 87 175±2676 ACHD‐related HF hospitalizations occurred between 1998 and 2011. During this time, ACHD HF hospitalizations increased 91% (4620±438–8809±740, P<0.0001) versus a 21% increase in non‐ACHD HF hospitalizations (P=0.003). ACHD HF hospitalization was associated with longer length of stay (ACHD HF versus non‐ACHD HF, 7.2±0.09 versus 6.8±0.02 days; P<0.0001), greater procedural burden, and higher charges ($81 332±$1650 versus $52 050±$379; P<0.0001). ACHD HF hospitalization charges increased 258% during the study period ($26 533±$1816 in 1998 versus $94 887±$8310 in 2011; P=0.0002), more than double that for non‐ACHD HF (P=0.04). Patients with ACHD HF hospitalized in high‐volume ACHD centers versus others were more likely to undergo invasive hemodynamic testing (30.2±0.6% versus 20.7±0.5%; P<0.0001) and to receive cardiac resynchronization/defibrillator devices (4.7±0.3% versus 1.8±0.2%; P<0.0001) and mechanical circulatory support (3.9±0.2% versus 2.4±0.2%; P<0.0001).Conclusions ACHD‐related HF hospitalizations have increased dramatically in recent years and are associated with disproportionately higher costs, procedural burden, and health resource use.

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Section: Discussionsupporting

confidence: 83%

Hospitalization Trends and Health Resource Use for Adult Congenital Heart Disease–Related Heart Failure

Burchill

Gao

Kovacs

et al. 2018

JAHA

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“…37 In addition, birth defects registries that only ascertain cases of birth defects in the first year of life exclude infants who died shortly after birth without an autopsy, or diagnosed later in childhood. Moreover, our study only includes live births, whereas other studies 8,12 include data on stillbirths and terminations. Without medical record review, the FBDR data also lack information on case confirmation or case severity.…”

Section: Original Articlesmentioning

confidence: 99%

Variation in the Prevalence of Congenital Heart Defects by Maternal Race/Ethnicity and Infant Sex

Nembhard

Wang

Loscalzo

et al. 2010

The Journal of Pediatrics

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Objective To determine the prevalence of major congenital heart defects (CHD) by ethnicity and sex. Study design Data from the Florida Birth Defects Registry was used to conduct a retrospective cohort study with 8029 singleton infants with 11 CHDs born 1998-2003 to resident non-Hispanic (NH) white, NH-black, and Hispanic women aged 15 to 49. Defect-specific prevalence rates, ratios, and 95% confidence intervals were calculated. Poisson regression was used to calculate adjusted ethnic-specific rate ratios (RR) for each CHD. Statistical significance was P < .0001.Results Compared with NH-whites, NH-black males had significantly increased rates of pulmonary valve atresia/ stenosis (RR = 1.66) but lower prevalence of aortic valve atresia/stenosis (RR = 0.33) and ventricular septal defect (VSD; RR = 0.78). Hispanic males had lower rates of aortic valve atresia/stenosis (RR = 0.28), coarctation of the aorta (RR = 0.61) and VSD (RR = 0.79). NH-black females had statistically significantly lower rates of VSD (RR = 0.75), and Hispanic females had lower rates of tetralogy of Fallot (RR = 0.54), VSD (RR = 0.84) and atrioventricular septal defects (RR = 0.53) compared with NH-whites.Conclusions We found differences in ethnic susceptibilities to CHD by sex, but the cause remains unclear. (J Pediatr 2010;156:259-64).

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“…The main reasons for fetal karyotyping were categorized as described by Kessler et al 6 The patients were classified according to the number of major and minor sonographic markers observed before and after puncturing for fetal karyotyping in accordance with Raniga et al 7 Abnormalities identified through imaging studies performed during prenatal care were also classified as single or multiple defects, in accordance with Staebler et al, 8 before and after performing fetal karyotyping. To determine the congenital heart defect observed, we used the classification suggested by Botto et al 9 The Kaplan-Meier test was used to construct the survival curve, by means of the BioEstat 5.0 software.…”

Section: Objectivementioning

confidence: 99%