Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992–2013

Xie, Shao-Hua; Rabbani, Sirus; Petrick, Jessica L.; Cook, Michael B.; Lagergren, Jesper

doi:10.1093/aje/kwx221

Cited by 32 publications

(25 citation statements)

References 26 publications

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“…In the USA, the incidence of OSCC in blacks, despite a steady decrease in recent years, is clearly higher than in other ethnic groups, whereas the incidence in whites is lowest. 5,14,15 The incidence of OAC has increased dramatically in whites, particularly in non-Hispanic whites, since the 1970s in the USA. However, the increase seems to have slowed down from the year 2000 onwards.…”

Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

“…However, the increase seems to have slowed down from the year 2000 onwards. 5,15 A recent analysis with multiple disparity measures of the racial and ethnic disparities in the USA in 1992-2013 showed decreased disparities in OSCC incidence over time and seemingly increasing absolute differences of OAC incidence across racial/ ethnic groups. 15 Some of the disparities by race may be explained by differences in the prevalence of exposure to major risk factors.…”

Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

“…5,15 A recent analysis with multiple disparity measures of the racial and ethnic disparities in the USA in 1992-2013 showed decreased disparities in OSCC incidence over time and seemingly increasing absolute differences of OAC incidence across racial/ ethnic groups. 15 Some of the disparities by race may be explained by differences in the prevalence of exposure to major risk factors. 15 In the UK, the incidence of OAC is also substantially higher in whites compared with black and Asian populations, while the incidence of OSCC is highest in blacks.…”

Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

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Social group disparities in the incidence and prognosis of oesophageal cancer

Xie

Lagergren

2018

United European Gastroenterology Journal

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There are substantial disparities in the incidence and prognosis of oesophageal cancer across social population groups, including sex, race/ethnicity, geographical location and socio-economic status. Both squamous cell carcinoma and adenocarcinoma of the oesophagus are more common in men than in women, but the male predominance in adenocarcinoma is stronger and less well understood. The varying incidence and prognosis of oesophageal cancer across racial/ethnic groups show distinct patterns by histological type. Individuals residing in rural areas have a higher incidence and worse prognosis than those in urban areas in developing regions. Lower socio-economic status is associated with an increased incidence and reduced survival in oesophageal cancer. Sustained research identifying novel preventive and therapeutic strategies are needed to reduce the risk of oesophageal cancer and improve the prognosis in all social groups.

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Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

Section: Racial and Ethnic Disparitiesmentioning

confidence: 99%

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Social group disparities in the incidence and prognosis of oesophageal cancer

Xie

Lagergren

2018

United European Gastroenterology Journal

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“…NHWs have the highest risk of oesophageal adenocarcinoma and adenocarcinoma accounts for nearly 68% of oesophageal cancer cases; however, SCC remains the predominant type in Chinese populations, regardless of immigrant status. [39][40][41] This phenomenon indicates that the difference in oesophageal cancer subtype might be partly determined at the genetic level. A number of genome-wide association studies of oesophageal SCC have been performed for Asian populations; certain unique variants in alcoholmetabolizing genes have been identified, which were not observed in non-Asian populations.…”

Section: Discussionmentioning

confidence: 93%

“…Regarding the histology of oesophageal cancer, there are two primary subtypes: adenocarcinoma and squamous cell cancer (SCC). NHWs have the highest risk of oesophageal adenocarcinoma and adenocarcinoma accounts for nearly 68% of oesophageal cancer cases; however, SCC remains the predominant type in Chinese populations, regardless of immigrant status . This phenomenon indicates that the difference in oesophageal cancer subtype might be partly determined at the genetic level.…”

Section: Discussionmentioning

confidence: 99%

The disparities in gastrointestinal cancer incidence among Chinese populations in Shanghai compared to Chinese immigrants and indigenous non‐Hispanic white populations in Los Angeles, USA

Liu

Lin

et al. 2019

Intl Journal of Cancer

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Gastrointestinal cancer patterns are distinct among populations. Our study aims to compare the incidence and risk of gastrointestinal cancers between Chinese American and non‐Hispanic whites in Los Angeles, CA, USA, to those of people indigenous to Shanghai to elucidate the changing patterns of gastrointestinal cancers. Cancer incidence data from 1988 to 2012 were extracted from the Cancer Incidence in Five Continents plus database. The age standardized incidence and estimated annual percentage change were calculated to estimate the temporal trends of gastrointestinal cancers. Traditional Poisson regression models and three‐factor constrained Poisson regression models were applied to compare the gastrointestinal cancer risk across populations. The incidences of oesophageal, stomach, liver and gall bladder cancers were higher among indigenous Chinese residents of Shanghai than among the other two populations in Los Angeles. While the incidences of colorectal and pancreatic cancer were higher among non‐Hispanic whites, Chinese American immigrants were considered to be at an intermediate level for most gastrointestinal cancers. The gender‐specific gastrointestinal cancer disparities across populations, especially between Shanghai Chinese and non‐Hispanic US whites, were significant regardless of age, period or cohort scale. However, the regional differences in gastrointestinal cancer rates decreased over time. Most gastrointestinal cancer patterns in Chinese American immigrants were more aligned to those of their new country of residence than to those of their original country. The disparities in gastrointestinal cancers across populations indicate that environmental factors might play a key role in cancer genesis. Shift in environmental exposures may result in significant changes in gastrointestinal cancer incidence.

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Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population‐based study

Cattelan

Ghazawi

et al. 2019

Cancer Medicine

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BackgroundEsophageal cancer can be subdivided into two main histological subtypes with significant variability in their etiology and epidemiology. The incidence of esophageal adenocarcinoma (AC) is increasing across the developed countries, whereas the incidence of esophageal squamous cell carcinoma (SCC) is declining. Several risk factors have been identified in the pathogenesis of each subtype, however, their epidemiologic characteristics and distribution throughout Canada remain poorly understood.MethodsWe performed a retrospective analysis of demographic data across Canada from 1992 to 2010 using two independent population‐based cancer registries. The incidence of esophageal cancer, for each subtype, was examined at the levels of provinces/territories, cities, and postal codes.ResultsA total of 19 790 patients were diagnosed with esophageal cancer in Canada between 1992 and 2010; 74% were males. The average national incidence rate was 33.5 cases per million individuals per year. Incidence of esophageal AC increased over time, with notable high‐incidence rates on the Vancouver Island, the coasts of the Great Lakes, and the coasts of the Northumberland Strait in the Maritimes. The overall incidence of esophageal SCC has decreased. However, high incidence of esophageal SCC was detected in the Vancouver city, rural eastern Québec, and in the Maritimes. We also report clustering for each subtype using postal codes, which sheds light onto new avenues of research for potential environmental etiologies.ConclusionsThis study, for the first time, provides a detailed analysis on the burden of esophageal cancer in Canada, revealing important geographic clustering trends.

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Racial and Ethnic Disparities in the Incidence of Esophageal Cancer in the United States, 1992–2013

Cited by 32 publications

References 26 publications

Social group disparities in the incidence and prognosis of oesophageal cancer

Social group disparities in the incidence and prognosis of oesophageal cancer

The disparities in gastrointestinal cancer incidence among Chinese populations in Shanghai compared to Chinese immigrants and indigenous non‐Hispanic white populations in Los Angeles, USA

Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population‐based study

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