Racial and ethnic differences in the associations between social integration, C-reactive protein and depressive symptoms

Chapman, Alexander L.; Santos-Lozada, Alexis R.

doi:10.1016/j.ssmph.2020.100663

Cited by 7 publications

(14 citation statements)

References 61 publications

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“…Overall, the present systematic review reported that most studies here retrieved, found a positive association between elevated CRP levels and depression [29,51,52,54,55,61,63,64,66,67,[69][70][71][72][73]80,81,83,[90][91][92][93][94]100]. Conversely, other studies did not confirm this association [49,50,62,68,74,76,86,88,89].…”

Section: Discussioncontrasting

confidence: 54%

“…A cross-sectional study evaluated the association between social integration, race/ethnicity, inflammation, and depressive symptoms in US participants through the NHANES survey [51]. Participants were administered PHQ-8 and measured hs-CRP levels.…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

“…Participants were administered PHQ-8 and measured hs-CRP levels. Social integration and CRP levels were found to operate independently in their association with depressive symptoms only for the white population but not the black or the Hispanic one [51]. A cross-sectional study evaluated whether specific symptom clusters were associated with CRP levels and whether race/ethnicity affected this association in a sample of 10,149 U.S. individuals from the NHANES survey [48].…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

“…Based on our judgment, 40 studies were rated as "good" studies [16,45,46,48,49,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66]68,[71][72][73]75,76,78,81,83,[88][89][90][92][93][94][96][97][98]100] and 16 as "satisfactory" studies [47,50,67,69,70,74,77,79,80,82,[84]…”

Section: Quality Assessmentmentioning

confidence: 99%

“…The cognitive function of MDD patients with high baseline CRP levels may remain impaired even after antidepressant treatment that improves depressive symptoms [51] Cross-sectional study…”

mentioning

confidence: 99%

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C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Orsolini

Pompili

Valenta

et al. 2022

IJMS

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The etiopathogenesis of depression is not entirely understood. Several studies have investigated the role of inflammation in major depressive disorder. The present work aims to review the literature on the association between C-Reactive Protein (CRP) and depression. A systematic review was performed for the topics of ‘CRP’ and ‘depression’ using the PubMed database from inception to December 2021. Fifty-six studies were identified and included in the review. Evidence suggested the presence of dysregulation in the inflammation system in individuals with depression. In most studies, higher blood CRP levels were associated with greater symptom severity, a specific pattern of depressive symptoms, and a worse response to treatment. Moreover, about one-third of depressed patients showed a low-grade inflammatory state, suggesting the presence of a different major depressive disorder (MDD) subgroup with a distinct etiopathogenesis, clinical course, treatment response, and prognosis, which could benefit from monitoring of CRP levels and might potentially respond to anti-inflammatory treatments. This work provides robust evidence about the potential role of CRP and its blood levels in depressive disorders. These findings can be relevant to developing new therapeutic strategies and better understanding if CRP may be considered a valuable biomarker for depression.

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Section: Discussioncontrasting

confidence: 54%

Section: Cross-sectional Studiesmentioning

confidence: 99%

Section: Cross-sectional Studiesmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

“…The cognitive function of MDD patients with high baseline CRP levels may remain impaired even after antidepressant treatment that improves depressive symptoms [51] Cross-sectional study…”

mentioning

confidence: 99%

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C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Orsolini

Pompili

Valenta

et al. 2022

IJMS

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Association between psychosocial factors and C-reactive protein across income, race, and sex.

Cundiff¹,

Bennett²,

Williams³

et al. 2024

Health Psychology

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Objective: A health disparity is a health difference that adversely affects disadvantaged populations, and thus could plausibly be due to social factors. Biopsychosocial processes that contribute to health disparities are not well-understood. Establishing whether candidate biomarkers are similarly associated with biologically relevant psychosocial constructs across health disparity groups is a current gap in our understanding. Method: This study examined associations between perceived stress, depressive symptoms, and social support with C-reactive protein (CRP) and whether associations varied by race, sex, or income in 24,395 Black and White adults aged 45 years or older from the REGARDS population-based national cohort. Results: The association between depressive symptoms and CRP was slightly larger at higher (vs. lower) income levels and larger for men (vs. women) but did not vary by race. Associations between stress and CRP and social support and CRP were not moderated by income, race, or sex. An interaction between race and income, evidenced that higher income was more strongly associated with lower CRP in White participants compared to Black participants, consistent with the idea of “diminishing returns” of income for the health of Black Americans. Conclusions: Basic associations between these psychosocial factors and CRP are small and generally similar across income, race, and sex. Black and lower-income Americans likely evidence higher CRP due to greater exposure to psychosocial risk factors rather than increased biological vulnerability to these exposures. Additionally, given small associations, CRP should not be used as a proxy for the construct of psychosocial stress.

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Life’s Crucial 12: Updating and Enhancing the Life’s Essential 8 of Cardiovascular Health: A proposal from NHANES

Gou,

Dou

et al. 2024

Preprint

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Background: Life's Essential 8 (LE8) is a cardiovascular health (CVH) model but does not take into account mental health, an important cardiovascular risk factor, so we constructed Life's Crucial 12 (LC12), a comprehensive cardiovascular care model that takes CVH into account, based on LE8, and hypothesized that it would be a more reliable index of CVH, despite the additional information needed to calculate LC12. Objective: To construct an integrated cardiovascular care model LC12 based on LE8 that can take Psychological Health into account, and to report the association between LC12 and stroke. Design: Population-based, cross-sectional study. Setting: Various locations in the United States. Participants: This study was a cross-sectional study based on data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES), which included 4,478 U.S. adults (≥ 20 years old). Method: The composite cardiovascular care model LC12 with scores (range 0-100) defining low (0-49), medium (50-79) and high (80-100) CVH. Determination of stroke status was obtained by questionnaire. Associations were assessed using multivariate logistic regression models and restricted cubic spline models. Result: Among 4,478 participants, there were 2252 female and 2226 male participants (53.136% and 46.864%, respectively), and 250 participants (5.583%) were diagnosed with stroke. The mean values of LC12, Psychological Health, Health behaviors, and Health factors scores for participants with stroke were 68.953, 52.775, and 55.451, respectively, which were lower than those of Non-Stroke participants. After fully adjusting for confounders, the ORs for the LC 12, Psychological Health, Health Behaviors, and Health Factors moderate and high groups were 0.431 (0.226,0.822), 0.212 (0.060,0.755), 0.536 (0.297, 0.967), 0.357 (0.178,0.713), 0.759 (0.552, 1.043), 0.334 (0.179, 0.623), 0.565 (0.406, 0.786), 0.533 (0.286, 0.994), which were significantly associated with the risk of stroke (P-trend < 0.05) and there was a linear trend between subgroups with different scores (P-value < 0.001). However, no nonlinear dose relationship was observed (P-Nonlinearity > 0.05). Limitation: Because estimates are based on single measures, fluctuations over time could not be determined. Conclusion: These findings suggest that Psychological Health is important in CVH. CVH status assessed by LC12 (Psychological Health, Health behaviors, Health factors) was significantly associated with the risk of developing stroke. When LC12 scores are maintained at high levels, it is beneficial to decrease the risk of stroke.

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Racial and ethnic differences in the associations between social integration, C-reactive protein and depressive symptoms

Cited by 7 publications

References 61 publications

C-Reactive Protein as a Biomarker for Major Depressive Disorder?

C-Reactive Protein as a Biomarker for Major Depressive Disorder?

Association between psychosocial factors and C-reactive protein across income, race, and sex.

Life’s Crucial 12: Updating and Enhancing the Life’s Essential 8 of Cardiovascular Health: A proposal from NHANES

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